{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Natural+History+Study&page=2",
    "query": {
      "intervention": "Natural History Study",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Natural+History+Study&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-19T11:10:06.269Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01660984",
      "title": "Natural History Study of Children and Adults With Medullary Thyroid Cancer",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Medullary Thyroid Cancer"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Cancer Institute (NCI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Months",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "4 Months and older"
      },
      "enrollment_count": 105,
      "start_date": "2012-07-30",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-09-14",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01660984"
    },
    {
      "nct_id": "NCT02941263",
      "title": "Natural History of Geographic Atrophy Associated With Age-Related Macular Degeneration",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Age-Related Macular Degeneration"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Eye Institute (NEI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "55 Years to 120 Years"
      },
      "enrollment_count": 20,
      "start_date": "2017-03-08",
      "completion_date": "2024-05-22",
      "has_results": false,
      "last_update_posted_date": "2026-08-28",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02941263"
    },
    {
      "nct_id": "NCT05705674",
      "title": "The Natural History Study of Patients With Sanfilippo Disease(s) (MPS3)",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sanfilippo Syndrome",
        "MPS3"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Lysosomal and Rare Disorders Research and Treatment Center, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "5 Years to 99 Years"
      },
      "enrollment_count": 6,
      "start_date": "2023-05-01",
      "completion_date": "2024-12",
      "has_results": false,
      "last_update_posted_date": "2024-03-12",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Fairfax, Virginia",
      "locations": [
        {
          "city": "Fairfax",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05705674"
    },
    {
      "nct_id": "NCT00001396",
      "title": "Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop...",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hypertrophic Cardiomyopathy"
      ],
      "interventions": [
        {
          "name": "Paragon Pacemaker",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "5 Years to 20 Years"
      },
      "enrollment_count": 100,
      "start_date": "1993-10-06",
      "completion_date": "2008-07-23",
      "has_results": false,
      "last_update_posted_date": "2017-07-02",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00001396"
    },
    {
      "nct_id": "NCT00013559",
      "title": "Natural History Study of Smith-Magenis Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Smith-Magenis Syndrome (SMS)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Human Genome Research Institute (NHGRI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": "115 Years",
        "sex": "ALL",
        "summary": "1 Month to 115 Years"
      },
      "enrollment_count": 593,
      "start_date": "2001-03-19",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-09-09",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00013559"
    },
    {
      "nct_id": "NCT01139476",
      "title": "Specimen Collection for Agricultural Health Study Cohort Pesticide Exposure Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Multiple Myeloma",
        "Leukemia",
        "MGUS",
        "Monoclonal B-Cell Lymphocytosis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Cancer Institute (NCI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "MALE",
        "summary": "18 Years to 100 Years · Male only"
      },
      "enrollment_count": 1892,
      "start_date": "2010-06-15",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-08-28",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01139476"
    },
    {
      "nct_id": "NCT05440617",
      "title": "Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Ovarian Failure",
        "Infertility",
        "Early Menopause And Infertility In Females After Treatment For Childhood Cancer"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "35 Years",
        "sex": "FEMALE",
        "summary": "4 Years to 35 Years · Female only"
      },
      "enrollment_count": 100,
      "start_date": "2022-07-22",
      "completion_date": "2041-09-21",
      "has_results": false,
      "last_update_posted_date": "2026-09-16",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05440617"
    },
    {
      "nct_id": "NCT03810508",
      "title": "A Natural History Study of Charcot-Marie-Tooth 4J (CMT4J)",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Charcot-Marie-Tooth Disease",
        "Hereditary Motor and Sensory Neuropathy IV"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Neurogene Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 21,
      "start_date": "2019-07-18",
      "completion_date": "2022-02-15",
      "has_results": false,
      "last_update_posted_date": "2022-03-31",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 2,
      "location_summary": "Iowa City, Iowa • Dallas, Texas",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03810508"
    },
    {
      "nct_id": "NCT02453152",
      "title": "Respiratory Muscle Function in Untreated X-Linked Myotubular Myopathy (XLMTM)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "X-linked Myotubular Myopathy"
      ],
      "interventions": [
        {
          "name": "History and physical",
          "type": "OTHER"
        },
        {
          "name": "Tidal breathing",
          "type": "OTHER"
        },
        {
          "name": "Maximal respiratory pressures",
          "type": "OTHER"
        },
        {
          "name": "Peak cough flow",
          "type": "OTHER"
        },
        {
          "name": "Pediatric Evaluation of Disability Inventory",
          "type": "OTHER"
        },
        {
          "name": "PedsQL Multidimensional Fatigue Scale",
          "type": "OTHER"
        },
        {
          "name": "Review of ventilation requirements",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "14 Years",
        "sex": "MALE",
        "summary": "Up to 14 Years · Male only"
      },
      "enrollment_count": 28,
      "start_date": "2015-10",
      "completion_date": "2019-07-31",
      "has_results": false,
      "last_update_posted_date": "2021-02-15",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02453152"
    },
    {
      "nct_id": "NCT00046189",
      "title": "Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Xeroderma Pigmentosum",
        "Basal Cell Carcinoma",
        "Squamous Cell Carcinoma",
        "Melanoma",
        "Skin Cancer"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Cancer Institute (NCI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "1 Month to 99 Years"
      },
      "enrollment_count": 301,
      "start_date": "2003-04-07",
      "completion_date": "2024-01-05",
      "has_results": false,
      "last_update_posted_date": "2024-01-08",
      "last_synced_at": "2026-09-19T11:10:06.269Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00046189"
    }
  ]
}