{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Negative+Control+Dentifrice",
    "query": {
      "intervention": "Negative Control Dentifrice"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 36,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Negative+Control+Dentifrice&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T20:58:05.953Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06735235",
      "title": "Salivary Fluoride Clearance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Caries"
      ],
      "interventions": [
        {
          "name": "0 ppm F",
          "type": "DRUG"
        },
        {
          "name": "250 ppm F as MFP",
          "type": "DRUG"
        },
        {
          "name": "1100 ppm as MFP",
          "type": "DRUG"
        },
        {
          "name": "2800 ppm F as MFP",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Procter and Gamble",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2021-07-14",
      "completion_date": "2021-07-29",
      "has_results": false,
      "last_update_posted_date": "2024-12-16",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Mason, Ohio",
      "locations": [
        {
          "city": "Mason",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06735235"
    },
    {
      "nct_id": "NCT06354270",
      "title": "A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dentin Sensitivity"
      ],
      "interventions": [
        {
          "name": "Stannous fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Regular fluoride toothpaste (Crest Cavity Protection)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 115,
      "start_date": "2024-04-11",
      "completion_date": "2024-06-23",
      "has_results": true,
      "last_update_posted_date": "2025-06-25",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06354270"
    },
    {
      "nct_id": "NCT06136455",
      "title": "A Study to Investigate Salivary Flow and Potential of Hydrogen (pH) Following Use of Essential-Oil Containing Mouthwashes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Listerine Clinical Solutions Teeth Strength",
          "type": "DRUG"
        },
        {
          "name": "Listerine Total Care Zero Alcohol Mouthwash",
          "type": "DRUG"
        },
        {
          "name": "Listerine Cool Mint Zero Alcohol Mouthwash",
          "type": "OTHER"
        },
        {
          "name": "Colgate Cavity Protection Toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer Inc. (J&JCI)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 164,
      "start_date": "2023-11-13",
      "completion_date": "2023-11-16",
      "has_results": false,
      "last_update_posted_date": "2024-01-03",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06136455"
    },
    {
      "nct_id": "NCT07761715",
      "title": "The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Teeth Staining"
      ],
      "interventions": [
        {
          "name": "Toothpaste",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Boka LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-05-11",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-13",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07761715"
    },
    {
      "nct_id": "NCT01014143",
      "title": "Evaluating Commercial Anti-Plaque Products and Oral Rinse",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dental Plaque"
      ],
      "interventions": [
        {
          "name": "Fluoride",
          "type": "DRUG"
        },
        {
          "name": "Chlorhexidine digluconate",
          "type": "DRUG"
        },
        {
          "name": "Fluoride, triclosan",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "23 Years",
        "maximum_age": "81 Years",
        "sex": "ALL",
        "summary": "23 Years to 81 Years"
      },
      "enrollment_count": 26,
      "start_date": "2007-08",
      "completion_date": "2007-09",
      "has_results": true,
      "last_update_posted_date": "2011-06-14",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Northfield, New Jersey",
      "locations": [
        {
          "city": "Northfield",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01014143"
    },
    {
      "nct_id": "NCT04050722",
      "title": "A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Sensodyne Repair and Protect",
          "type": "DRUG"
        },
        {
          "name": "Colgate Cavity Protection",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 130,
      "start_date": "2019-10-07",
      "completion_date": "2019-11-13",
      "has_results": true,
      "last_update_posted_date": "2020-11-19",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Las Vegas, Nevada",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04050722"
    },
    {
      "nct_id": "NCT06143670",
      "title": "A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Stannous fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Sodium fluoride toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 159,
      "start_date": "2023-11-29",
      "completion_date": "2024-03-12",
      "has_results": true,
      "last_update_posted_date": "2025-03-21",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06143670"
    },
    {
      "nct_id": "NCT07219342",
      "title": "The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains) Over 8 Weeks of Unsupervised Use.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Teeth Staining"
      ],
      "interventions": [
        {
          "name": "Toothpaste",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Boka LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 109,
      "start_date": "2025-09-11",
      "completion_date": "2025-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-11",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07219342"
    },
    {
      "nct_id": "NCT02151058",
      "title": "A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Stain"
      ],
      "interventions": [
        {
          "name": "Colgate® Regular Cavity Protection",
          "type": "DRUG"
        },
        {
          "name": "Experimental Mouth Rinse",
          "type": "DRUG"
        },
        {
          "name": "Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 227,
      "start_date": "2014-06",
      "completion_date": "2014-07",
      "has_results": true,
      "last_update_posted_date": "2015-06-01",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02151058"
    },
    {
      "nct_id": "NCT06660069",
      "title": "A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Plaque",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste)",
          "type": "DRUG"
        },
        {
          "name": "CPC Mouthwash (Parodontax Active Gum Health Mouthwash)",
          "type": "DRUG"
        },
        {
          "name": "Regular Fluoride Toothpaste (Crest Cavity Protection)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 199,
      "start_date": "2024-11-18",
      "completion_date": "2025-03-11",
      "has_results": true,
      "last_update_posted_date": "2026-03-18",
      "last_synced_at": "2026-09-03T20:58:05.953Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06660069"
    }
  ]
}