{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Negative+Control+Toothpaste", "query": { "intervention": "Negative Control Toothpaste" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 35, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Negative+Control+Toothpaste&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-05T21:27:06.982Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07419685", "title": "Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Negative Control Toothpaste", "type": "DRUG" }, { "name": "Active Comparator", "type": "DRUG" }, { "name": "Test Toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Church & Dwight Company, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 31, "start_date": "2024-10-08", "completion_date": "2025-01-17", "has_results": false, "last_update_posted_date": "2026-02-19", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Noblesville, Indiana", "locations": [ { "city": "Noblesville", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07419685" }, { "nct_id": "NCT06143670", "title": "A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous fluoride toothpaste", "type": "DRUG" }, { "name": "Sodium fluoride toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 159, "start_date": "2023-11-29", "completion_date": "2024-03-12", "has_results": true, "last_update_posted_date": "2025-03-21", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06143670" }, { "nct_id": "NCT03970759", "title": "Meta-analysis of Stannous Fluoride and the Effects on Gingival Health", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous Fluoride Dentifrice", "type": "DRUG" }, { "name": "Positive control dentifrice", "type": "DRUG" }, { "name": "Negative control dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2890, "start_date": "2018-01-08", "completion_date": "2018-11-30", "has_results": false, "last_update_posted_date": "2019-06-17", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Cincinnati, Ohio", "locations": [ { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT03970759" }, { "nct_id": "NCT01419626", "title": "A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Interdental cleaning device with water", "type": "DEVICE" }, { "name": "Interdental cleaning device with essential-oil mouthrinse", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 140, "start_date": "2011-07-31", "completion_date": "2011-08-31", "has_results": true, "last_update_posted_date": "2019-12-17", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT01419626" }, { "nct_id": "NCT01494649", "title": "Pilot Study to Investigate the Efficacy of a Toothpaste in Providing Relief From Dentinal Hypersensitivity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dentinal Sensitivity", "Hypersensitivity" ], "interventions": [ { "name": "Test Toothpaste", "type": "DRUG" }, { "name": "Negative Control Toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 118, "start_date": "2011-09", "completion_date": "2011-09", "has_results": true, "last_update_posted_date": "2013-05-08", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT01494649" }, { "nct_id": "NCT04005417", "title": "Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Dentine Hypersensitivity" ], "interventions": [ { "name": "Stannous fluoride dentifrice", "type": "DRUG" }, { "name": "Positive control dentifrice", "type": "DRUG" }, { "name": "Negative control dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1036, "start_date": "2018-01-08", "completion_date": "2018-11-30", "has_results": false, "last_update_posted_date": "2019-07-02", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Cincinnati, Ohio", "locations": [ { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04005417" }, { "nct_id": "NCT01024738", "title": "Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dental Plaque" ], "interventions": [ { "name": "Fluoride", "type": "DRUG" }, { "name": "Triclosan, fluoride", "type": "DRUG" }, { "name": "Chlorhexidine Gluconate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Colgate Palmolive", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 22, "start_date": "2008-03", "completion_date": "2008-04", "has_results": true, "last_update_posted_date": "2009-12-03", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Paramus, New Jersey", "locations": [ { "city": "Paramus", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT01024738" }, { "nct_id": "NCT00762151", "title": "A Study to Investigate the Anti-Plaque Effect of AN0128 Toothpaste", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Dental Plaque" ], "interventions": [ { "name": "Negative Control (Regular Toothpaste)", "type": "OTHER" }, { "name": "Positive Control (anti-plaque/anti-bacterial toothpaste)", "type": "OTHER" }, { "name": "Prototype (AN0128 Toothpaste)", "type": "DRUG" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 18, "start_date": "2007-11", "completion_date": "2008-01", "has_results": false, "last_update_posted_date": "2019-06-05", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Cedar Knolls, New Jersey", "locations": [ { "city": "Cedar Knolls", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00762151" }, { "nct_id": "NCT06949072", "title": "A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Test Dentifrice", "type": "DRUG" }, { "name": "Reference Dentifrice", "type": "DRUG" }, { "name": "Negative Control Dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 47, "start_date": "2025-04-28", "completion_date": "2025-09-11", "has_results": false, "last_update_posted_date": "2025-09-24", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06949072" }, { "nct_id": "NCT04123665", "title": "A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous fluoride", "type": "DRUG" }, { "name": "Sodium monofluorophosphate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 98, "start_date": "2013-05-28", "completion_date": "2013-12-11", "has_results": true, "last_update_posted_date": "2020-01-31", "last_synced_at": "2026-09-05T21:27:06.982Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04123665" } ] }