{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Negative+Ion+Generator",
    "query": {
      "intervention": "Negative Ion Generator"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 11,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Negative+Ion+Generator&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-05T10:03:06.287Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03968874",
      "title": "Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Light box therapy",
          "type": "DEVICE"
        },
        {
          "name": "Negative Ion Generator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Portland VA Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "88 Years",
        "sex": "ALL",
        "summary": "18 Years to 88 Years"
      },
      "enrollment_count": 300,
      "start_date": "2019-08-01",
      "completion_date": "2025-12-01",
      "has_results": false,
      "last_update_posted_date": "2025-11-14",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03968874"
    },
    {
      "nct_id": "NCT00809523",
      "title": "A Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Seasonal Affective Disorder"
      ],
      "interventions": [
        {
          "name": "Negative Ion Generator",
          "type": "DEVICE"
        },
        {
          "name": "Light-emitting Photodiode light treatment device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 106,
      "start_date": "2008-12",
      "completion_date": "2010-04",
      "has_results": true,
      "last_update_posted_date": "2013-03-06",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 3,
      "location_summary": "New Haven, Connecticut • Rockville, Maryland • Belmont, Massachusetts",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "Belmont",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00809523"
    },
    {
      "nct_id": "NCT01064700",
      "title": "Bright Light: A Novel Treatment for Anxiety",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Anxiety",
        "Depression",
        "Sleep"
      ],
      "interventions": [
        {
          "name": "Litebook Bright Light Box",
          "type": "DEVICE"
        },
        {
          "name": "Litebook inactivated negation ion generator (the placebo)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 33,
      "start_date": "2006-10",
      "completion_date": "2007-12",
      "has_results": false,
      "last_update_posted_date": "2021-04-28",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 1,
      "location_summary": "Columbia, South Carolina",
      "locations": [
        {
          "city": "Columbia",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01064700"
    },
    {
      "nct_id": "NCT00139997",
      "title": "Environmental Treatment for Seasonal Affective Disorder (SAD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Seasonal Affective Disorder"
      ],
      "interventions": [
        {
          "name": "Litebook treatment devices",
          "type": "DEVICE"
        },
        {
          "name": "Inactivated negative ion generator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 26,
      "start_date": "2002-01",
      "completion_date": "2005-08",
      "has_results": true,
      "last_update_posted_date": "2013-03-06",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00139997"
    },
    {
      "nct_id": "NCT00006517",
      "title": "Clinical Trials of Three Non-Drug Treatments for Winter Depression (SAD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Seasonal Affective Disorder",
        "Mood Disorders",
        "Depression"
      ],
      "interventions": [
        {
          "name": "bright light box",
          "type": "DEVICE"
        },
        {
          "name": "dawn simulator",
          "type": "DEVICE"
        },
        {
          "name": "high-output negative ion generator",
          "type": "DEVICE"
        },
        {
          "name": "low-output negative ion generator",
          "type": "DEVICE"
        },
        {
          "name": "dawn light pulse",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "New York State Psychiatric Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 150,
      "start_date": "1998-09",
      "completion_date": "2004-04",
      "has_results": false,
      "last_update_posted_date": "2015-06-03",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00006517"
    },
    {
      "nct_id": "NCT07055633",
      "title": "Improving Cognitive Rehabilitation Outcomes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mild Traumatic Brain Injury",
        "Posttraumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "CCT+MBLT",
          "type": "DEVICE"
        },
        {
          "name": "CCT+ION",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 144,
      "start_date": "2026-04-01",
      "completion_date": "2030-09-30",
      "has_results": false,
      "last_update_posted_date": "2026-04-24",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 2,
      "location_summary": "San Diego, California • Portland, Oregon",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07055633"
    },
    {
      "nct_id": "NCT00006172",
      "title": "Clinical Trials of Two Non-drug Treatments for Chronic Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mood Disorders",
        "Depressive Disorders",
        "Depression",
        "Chronic Depression"
      ],
      "interventions": [
        {
          "name": "Bright light box",
          "type": "DEVICE"
        },
        {
          "name": "High-output negative ion generator",
          "type": "DEVICE"
        },
        {
          "name": "Low-output negative ion generator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "New York State Psychiatric Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 32,
      "start_date": "2000-04",
      "completion_date": "2004-02",
      "has_results": false,
      "last_update_posted_date": "2014-10-01",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 2,
      "location_summary": "Middletown, Connecticut • New York, New York",
      "locations": [
        {
          "city": "Middletown",
          "state": "Connecticut"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00006172"
    },
    {
      "nct_id": "NCT00701064",
      "title": "Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Posttraumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Bright Light Exposure",
          "type": "OTHER"
        },
        {
          "name": "Negative Ion Generator",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 71,
      "start_date": "2009-01-01",
      "completion_date": "2019-09-02",
      "has_results": true,
      "last_update_posted_date": "2019-09-24",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 1,
      "location_summary": "Columbia, Arizona",
      "locations": [
        {
          "city": "Columbia",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00701064"
    },
    {
      "nct_id": "NCT06477796",
      "title": "Improving Sleep in Veterans With the Polytrauma Clinical Triad",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Post-traumatic Stress Disorder",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Morning Bright Light Therapy",
          "type": "DEVICE"
        },
        {
          "name": "Negative Ion Generator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 96,
      "start_date": "2025-05-01",
      "completion_date": "2028-09-29",
      "has_results": false,
      "last_update_posted_date": "2026-06-29",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06477796"
    },
    {
      "nct_id": "NCT07601841",
      "title": "Light Therapy to Improve Sleep in TBI: Sleep-active Biomarkers and Glymphatic Function",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep",
        "Phototherapy",
        "Glymphatic System",
        "Mitochondrial Dynamics",
        "Brain Injuries, Traumatic",
        "Inflammation"
      ],
      "interventions": [
        {
          "name": "Morning Bright Light Therapy",
          "type": "DEVICE"
        },
        {
          "name": "Negative Ion Generator Therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 300,
      "start_date": "2025-12-12",
      "completion_date": "2030-09-30",
      "has_results": false,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-09-05T10:03:06.287Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07601841"
    }
  ]
}