{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nicotine+%282+mg%29",
    "query": {
      "intervention": "Nicotine (2 mg)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 269,
    "total_pages": 27,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nicotine+%282+mg%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-24T07:55:03.961Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01923467",
      "title": "Project Quit: Positive vs. Negative Offers of an Online Stop Smoking Program",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Project Quit stop smoking program",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine patches 21 mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 767,
      "start_date": "2013-08",
      "completion_date": "2014-04",
      "has_results": true,
      "last_update_posted_date": "2015-06-15",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01923467"
    },
    {
      "nct_id": "NCT00770666",
      "title": "Combination Medications vs. Patch Alone for Medically-Ill Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Nicotine patch, nicotine inhaler, bupropion",
          "type": "DRUG"
        },
        {
          "name": "Nicotine patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Medicine and Dentistry of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 127,
      "start_date": "2005-09",
      "completion_date": "2008-01",
      "has_results": false,
      "last_update_posted_date": "2008-10-10",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "New Brunswick, New Jersey",
      "locations": [
        {
          "city": "New Brunswick",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00770666"
    },
    {
      "nct_id": "NCT04199117",
      "title": "Health Systems Reach Interventions Project",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking, Cigarette",
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Combination nicotine patch and nicotine mini-lozenge treatment",
          "type": "DRUG"
        },
        {
          "name": "Monetary incentives for initiating treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Automated tailored outreach",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Care management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Wisconsin Tobacco Quit Line referral",
          "type": "OTHER"
        },
        {
          "name": "Primary care provider referral",
          "type": "OTHER"
        },
        {
          "name": "Untailored outreach",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Multiple smoking cessation coaching calls",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 210,
      "start_date": "2020-03-11",
      "completion_date": "2024-10-16",
      "has_results": true,
      "last_update_posted_date": "2025-09-24",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04199117"
    },
    {
      "nct_id": "NCT02723162",
      "title": "Translational Neuropsychopharmacology Research of Nicotine Addiction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nicotine Dependence, Cigarettes"
      ],
      "interventions": [
        {
          "name": "Varenicline (VRN)",
          "type": "DRUG"
        },
        {
          "name": "N-Acetylcysteine (NAC)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 67,
      "start_date": "2016-05-04",
      "completion_date": "2020-03-09",
      "has_results": true,
      "last_update_posted_date": "2022-08-18",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02723162"
    },
    {
      "nct_id": "NCT02312934",
      "title": "Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Chemo Brain",
        "Chemotherapy-related Cognitive Impairment",
        "Chemo Fog",
        "Breast Cancer",
        "Chemobrain"
      ],
      "interventions": [
        {
          "name": "Transdermal nicotine",
          "type": "DRUG"
        },
        {
          "name": "Placebo Transdermal Patch",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "80 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 80 Years · Female only"
      },
      "enrollment_count": 22,
      "start_date": "2015-08",
      "completion_date": "2018-05",
      "has_results": true,
      "last_update_posted_date": "2020-01-21",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02312934"
    },
    {
      "nct_id": "NCT00931021",
      "title": "Smoking Cessation Treatment for Head and Neck Cancer Patients",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Varenicline (Chantix)",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 7,
      "start_date": "2009-07",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2013-07-15",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00931021"
    },
    {
      "nct_id": "NCT05396014",
      "title": "The BEST Trial: Biomarkers for Evaluating Spine Treatments",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Chronic Low-back Pain"
      ],
      "interventions": [
        {
          "name": "Enhanced Self-Care (ESC)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Acceptance and Commitment Therapy (ACT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Evidence-Based Exercise and Manual Therapy (EBEM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Duloxetine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1014,
      "start_date": "2022-09-12",
      "completion_date": "2024-10-22",
      "has_results": true,
      "last_update_posted_date": "2025-07-23",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 12,
      "location_summary": "Redwood City, California • San Diego, California • San Francisco, California + 9 more",
      "locations": [
        {
          "city": "Redwood City",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05396014"
    },
    {
      "nct_id": "NCT04717544",
      "title": "Embedding Comprehensive Smoking Cessation Programs Into Community Clinics",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Intervention Arm",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Friends Research Institute, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 406,
      "start_date": "2019-10-01",
      "completion_date": "2022-11-30",
      "has_results": false,
      "last_update_posted_date": "2023-08-14",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04717544"
    },
    {
      "nct_id": "NCT02482233",
      "title": "The END Perioperative Smoking Pilot Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking",
        "Nicotine Addiction",
        "Surgery"
      ],
      "interventions": [
        {
          "name": "ENDD (NJOY)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "NRT (NicoDerm CQ)",
          "type": "DRUG"
        },
        {
          "name": "telephone counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "brief advice",
          "type": "BEHAVIORAL"
        },
        {
          "name": "brochure",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2015-08",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2022-03-09",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02482233"
    },
    {
      "nct_id": "NCT00933595",
      "title": "Longitudinal Studies of HIV-Associated Lung Infections and Complications (Lung HIV)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pulmonary Complications",
        "HIV Infections"
      ],
      "interventions": [
        {
          "name": "Smoking Cessation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": null,
      "start_date": "2007-09",
      "completion_date": "2013-11",
      "has_results": false,
      "last_update_posted_date": "2016-09-01",
      "last_synced_at": "2026-09-24T07:55:03.961Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00933595"
    }
  ]
}