{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nicotine+%285+mg%29",
    "query": {
      "intervention": "Nicotine (5 mg)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 115,
    "total_pages": 12,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nicotine+%285+mg%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-25T05:13:54.996Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00087880",
      "title": "Maintaining Abstinence in Chronic Cigarette Smokers - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Bupropion and NRT",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 407,
      "start_date": "2002-12",
      "completion_date": "2009-09",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00087880"
    },
    {
      "nct_id": "NCT03082482",
      "title": "Smartphone-delivered Automated Video-assisted Smoking Treatment for People Living With HIV",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Self-help materials",
          "type": "BEHAVIORAL"
        },
        {
          "name": "nicotine patch",
          "type": "DRUG"
        },
        {
          "name": "Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Smartphone-delivered automated treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Oklahoma",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 20,
      "start_date": "2017-05-15",
      "completion_date": "2017-12-31",
      "has_results": false,
      "last_update_posted_date": "2018-04-11",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03082482"
    },
    {
      "nct_id": "NCT02564315",
      "title": "The Long-Term Quitting (Smoking Cessation) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Nicotine Mini-Lozenge for 11 Months",
          "type": "DRUG"
        },
        {
          "name": "Preparation Phase Behavioral Reduction Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Preparation Phase Recycling Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Preparation Phase Control Treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cessation Phase Supportive Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cessation Phase Skill Training Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cessation Phase Brief Information",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cessation Phase Nicotine Patch + Nicotine Mini-Lozenge",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1154,
      "start_date": "2015-10-30",
      "completion_date": "2019-11-05",
      "has_results": false,
      "last_update_posted_date": "2020-02-17",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02564315"
    },
    {
      "nct_id": "NCT01944423",
      "title": "Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Nicotine Addiction",
        "Panic Attack"
      ],
      "interventions": [
        {
          "name": "d-cycloserine",
          "type": "DRUG"
        },
        {
          "name": "Pill Placebo",
          "type": "DRUG"
        },
        {
          "name": "Nicotine replacement therapy",
          "type": "DRUG"
        },
        {
          "name": "Panic and Smoking Reduction Treatment",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 53,
      "start_date": "2013-10",
      "completion_date": "2018-10",
      "has_results": true,
      "last_update_posted_date": "2021-05-19",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01944423"
    },
    {
      "nct_id": "NCT06356610",
      "title": "Pharmacokinetic and Subjective Effects of Heated Tobacco Products",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "Product A",
          "type": "OTHER"
        },
        {
          "name": "Product B",
          "type": "OTHER"
        },
        {
          "name": "Product C",
          "type": "OTHER"
        },
        {
          "name": "Product D",
          "type": "OTHER"
        },
        {
          "name": "Product E",
          "type": "OTHER"
        },
        {
          "name": "Product F",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Altria Client Services LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 80,
      "start_date": "2024-02-06",
      "completion_date": "2024-12-18",
      "has_results": true,
      "last_update_posted_date": "2026-03-27",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 3,
      "location_summary": "Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        },
        {
          "city": "Knoxville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06356610"
    },
    {
      "nct_id": "NCT03060278",
      "title": "Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Self-help materials",
          "type": "BEHAVIORAL"
        },
        {
          "name": "nicotine patch",
          "type": "DRUG"
        },
        {
          "name": "Smartphone-delivered automated treatment",
          "type": "OTHER"
        },
        {
          "name": "Counseling",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Oklahoma",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 20,
      "start_date": "2017-05-15",
      "completion_date": "2017-12-31",
      "has_results": false,
      "last_update_posted_date": "2018-04-12",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03060278"
    },
    {
      "nct_id": "NCT06966362",
      "title": "Varenicline for Smoking Reduction in Veterans Not Ready To Quit",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Veterans",
        "Tobacco Use Disorder",
        "Cigarette Smoking",
        "Tobacco Dependence"
      ],
      "interventions": [
        {
          "name": "Motivation-Phase Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Motivation-Phase Nicotine Mini-Lozenge",
          "type": "DRUG"
        },
        {
          "name": "Cessation-Phase Combination Nicotine Replacement Therapy (NRT)",
          "type": "DRUG"
        },
        {
          "name": "Cessation-Phase Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Motivation-Phase Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cessation-Phase Counseling",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 400,
      "start_date": "2026-08-17",
      "completion_date": "2030-06-28",
      "has_results": false,
      "last_update_posted_date": "2026-08-31",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 4,
      "location_summary": "San Diego, California • Minneapolis, Minnesota • Durham, North Carolina + 1 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06966362"
    },
    {
      "nct_id": "NCT01122238",
      "title": "Identifying Treatments to Motivate Smokers to Quit",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking",
        "Smoking Cessation",
        "Motivation",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Nicotine Patch",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Gum",
          "type": "DRUG"
        },
        {
          "name": "Motivational Interviewing",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Smoking Reduction",
          "type": "BEHAVIORAL"
        },
        {
          "name": "No Intervention",
          "type": "OTHER"
        },
        {
          "name": "Nicotine Patch + Nicotine Gum",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 517,
      "start_date": "2010-06",
      "completion_date": "2014-05",
      "has_results": true,
      "last_update_posted_date": "2015-12-16",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01122238"
    },
    {
      "nct_id": "NCT01008748",
      "title": "Determinants of Smoking Cessation Among Latinos",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Nicotine Replacement Therapy (NRT)",
          "type": "DRUG"
        },
        {
          "name": "Questionnaire",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Self-Help Materials",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 200,
      "start_date": "2009-09",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2020-03-19",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01008748"
    },
    {
      "nct_id": "NCT04038515",
      "title": "Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nicotine",
        "E-liquid Flavors"
      ],
      "interventions": [
        {
          "name": "Nicotine 0 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 6 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 12 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 24 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "'Menthol' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Menthol/Mint' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Green Apple' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Watermelon' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Unflavored'",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 54,
      "start_date": "2022-10-27",
      "completion_date": "2024-06-03",
      "has_results": false,
      "last_update_posted_date": "2024-08-05",
      "last_synced_at": "2026-09-25T05:13:54.996Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04038515"
    }
  ]
}