{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nicotine+replacement&page=6",
    "query": {
      "intervention": "Nicotine replacement",
      "page": 6
    },
    "page_size": 10
  },
  "pagination": {
    "page": 6,
    "page_size": 10,
    "total_count": 429,
    "total_pages": 43,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nicotine+replacement&page=7&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nicotine+replacement&page=5&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-15T18:18:17.715Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00888979",
      "title": "Pilot Study of Nicotine Replacement for Smoking Cessation During Pregnancy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Nicotrol Inhaler",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hartford Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 10,
      "start_date": "2009-04",
      "completion_date": "2014-04",
      "has_results": true,
      "last_update_posted_date": "2017-01-09",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Hartford, Connecticut",
      "locations": [
        {
          "city": "Hartford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00888979"
    },
    {
      "nct_id": "NCT02873754",
      "title": "Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Cognitive Behavioral Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mobile Contingency Management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Transdermal nicotine patch",
          "type": "DRUG"
        },
        {
          "name": "Nicotine polacrilex",
          "type": "DRUG"
        },
        {
          "name": "Nicotine lozenge",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 11,
      "start_date": "2017-01",
      "completion_date": "2017-07",
      "has_results": true,
      "last_update_posted_date": "2018-07-13",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02873754"
    },
    {
      "nct_id": "NCT00807742",
      "title": "Contingency Management for Smoking in Substance Abusers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Abuse"
      ],
      "interventions": [
        {
          "name": "Nicotine Replacement Treatment (NRT)",
          "type": "DRUG"
        },
        {
          "name": "Brief Advice",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Contingency Management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Non-Contingent Reinforcement",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 340,
      "start_date": "2008-10",
      "completion_date": "2014-04",
      "has_results": true,
      "last_update_posted_date": "2019-01-23",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00807742"
    },
    {
      "nct_id": "NCT03856515",
      "title": "Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking-Related Carcinoma"
      ],
      "interventions": [
        {
          "name": "Nicotine Replacement",
          "type": "DRUG"
        },
        {
          "name": "Questionnaire Administration",
          "type": "OTHER"
        },
        {
          "name": "Electronic Cigarette",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 169,
      "start_date": "2022-06-02",
      "completion_date": "2026-01-07",
      "has_results": true,
      "last_update_posted_date": "2026-01-28",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03856515"
    },
    {
      "nct_id": "NCT03603496",
      "title": "Post-Discharge Smoking Cessation Strategies: Helping HAND 4",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Transitional Tobacco Care Management (TTCM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "eReferral to State Tobacco Quitline (QL)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine replacement therapy",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1416,
      "start_date": "2018-09-01",
      "completion_date": "2020-11-17",
      "has_results": true,
      "last_update_posted_date": "2022-05-05",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 3,
      "location_summary": "Boston, Massachusetts • Pittsburgh, Pennsylvania • Nashville, Tennessee",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03603496"
    },
    {
      "nct_id": "NCT02424188",
      "title": "Trial of Integrated Smoking Cessation, Exercise and Weight Management in Serious Mental Illness: TRIUMPH",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mental Illness"
      ],
      "interventions": [
        {
          "name": "TRIIUMPH Intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 192,
      "start_date": "2016-07-07",
      "completion_date": "2020-03",
      "has_results": true,
      "last_update_posted_date": "2025-06-25",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02424188"
    },
    {
      "nct_id": "NCT01337817",
      "title": "A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Tobacco Use Disorder",
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Ariva Silver Wintergreen",
          "type": "OTHER"
        },
        {
          "name": "Ariva Wintergreen",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Star Scientific, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "23 Years",
        "maximum_age": "72 Years",
        "sex": "ALL",
        "summary": "23 Years to 72 Years"
      },
      "enrollment_count": 37,
      "start_date": "2009-09",
      "completion_date": "2009-09",
      "has_results": false,
      "last_update_posted_date": "2014-10-24",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Martinsburg, West Virginia",
      "locations": [
        {
          "city": "Martinsburg",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01337817"
    },
    {
      "nct_id": "NCT02020005",
      "title": "Evaluation of Cessation Preferences of Menthol Smoker",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Non-flavored 2mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Non-flavored 4mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Mint-flavored 2mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Mint-flavored 4mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Non-flavored nicotine inhaler",
          "type": "OTHER"
        },
        {
          "name": "Mint-flavored nicotine ihaler",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2013-09",
      "completion_date": "2013-12",
      "has_results": false,
      "last_update_posted_date": "2025-10-03",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02020005"
    },
    {
      "nct_id": "NCT01120704",
      "title": "Evaluation of Treatments to Improve Smoking Cessation Medication Adherence",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking",
        "Smoking Cessation",
        "Adherence",
        "Nicotine Dependence",
        "Motivation"
      ],
      "interventions": [
        {
          "name": "Short Term Combination Nicotine Replacement Therapy (patch + gum)",
          "type": "DRUG"
        },
        {
          "name": "Long Term Combination Nicotine Replacement Therapy (patch + gum)",
          "type": "DRUG"
        },
        {
          "name": "Intensive Maintenance Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Medication Adherence Counseling (CAM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Electronic Medication Monitoring Device (the Helping Hand) + Feedback",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Automated Adherence Prompting Phone Calls",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 544,
      "start_date": "2010-06",
      "completion_date": "2014-05",
      "has_results": true,
      "last_update_posted_date": "2015-12-11",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01120704"
    },
    {
      "nct_id": "NCT00448344",
      "title": "Family-supported Smoking Cessation for Chronically Ill Veterans",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Disease",
        "Neoplasm",
        "Cardiovascular Disease",
        "Pulmonary Disease, Chronic Obstructive",
        "Diabetes Mellitus",
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Family-supported",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Standard Telephone counseling",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 471,
      "start_date": "2008-02",
      "completion_date": "2012-07",
      "has_results": true,
      "last_update_posted_date": "2015-04-24",
      "last_synced_at": "2026-11-15T18:18:17.715Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00448344"
    }
  ]
}