{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nitrates&page=2",
    "query": {
      "intervention": "Nitrates",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nitrates&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-15T05:38:40.101Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03787082",
      "title": "Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Pulmonary Hypertension",
        "Heart Failure With Normal Ejection Fraction",
        "Pulmonary Heart Disease and Diseases of Pulmonary Circulation"
      ],
      "interventions": [
        {
          "name": "Nitrates",
          "type": "DRUG"
        },
        {
          "name": "Chlorhexidine Gluconate Mouthwash",
          "type": "DRUG"
        },
        {
          "name": "Placebo Mouthwash",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Gladwin, Mark, MD",
      "sponsor_class": "INDIV",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2022-12",
      "completion_date": "2023-12",
      "has_results": false,
      "last_update_posted_date": "2022-07-07",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03787082"
    },
    {
      "nct_id": "NCT07485231",
      "title": "Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post Traumatic Stress Disorder",
        "Trauma"
      ],
      "interventions": [
        {
          "name": "Beetroot Juice",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Juice",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2026-02-18",
      "completion_date": "2028-05-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-03",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07485231"
    },
    {
      "nct_id": "NCT02433977",
      "title": "The Effects of NOx and Conjugated Linoleic Acid on Asthmatics",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Asthma"
      ],
      "interventions": [
        {
          "name": "Conjugated Linolenic Acid",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Sodium Nitrite",
          "type": "DRUG"
        },
        {
          "name": "Sodium Nitrate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "DRUG"
      ],
      "sponsor": "Gladwin, Mark, MD",
      "sponsor_class": "INDIV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 6,
      "start_date": "2015-09",
      "completion_date": "2019-11",
      "has_results": true,
      "last_update_posted_date": "2021-04-27",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02433977"
    },
    {
      "nct_id": "NCT03545009",
      "title": "Determination of the Independent Effects of Beetroot Juice Components, Dietary Nitrate and Antioxidants, on Exercise Tolerance and Health Benefits in Individuals With Obesity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Metabolic Disease",
        "Obesity",
        "Exercise"
      ],
      "interventions": [
        {
          "name": "Sodium Nitrate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Beetroot Juice no Nitrate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Beetroot Juice",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 16,
      "start_date": "2018-08-10",
      "completion_date": "2020-08-30",
      "has_results": false,
      "last_update_posted_date": "2021-09-22",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03545009"
    },
    {
      "nct_id": "NCT05138575",
      "title": "SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Heart Failure With Preserved Ejection Fraction"
      ],
      "interventions": [
        {
          "name": "Empagliflozin + Potassium Chloride",
          "type": "DRUG"
        },
        {
          "name": "Empagliflozin + Potassium Nitrate",
          "type": "DRUG"
        },
        {
          "name": "Potassium Chloride + Placebo for Empagliflozin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 53,
      "start_date": "2022-01-24",
      "completion_date": "2027-05-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-16",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05138575"
    },
    {
      "nct_id": "NCT02354859",
      "title": "A Phase 2 IV Gallium Study for Patients With Cystic Fibrosis (IGNITE Study)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cystic Fibrosis"
      ],
      "interventions": [
        {
          "name": "Gallium nitrate",
          "type": "DRUG"
        },
        {
          "name": "Normal Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 119,
      "start_date": "2016-03",
      "completion_date": "2018-02-01",
      "has_results": true,
      "last_update_posted_date": "2019-03-21",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 23,
      "location_summary": "Birmingham, Alabama • La Jolla, California • Denver, Colorado + 20 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02354859"
    },
    {
      "nct_id": "NCT00662896",
      "title": "To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Osteoarthritis",
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "naproxcinod 375 mg bid",
          "type": "DRUG"
        },
        {
          "name": "naproxcinod 750 mg bid",
          "type": "DRUG"
        },
        {
          "name": "naproxen 250 mg bid",
          "type": "DRUG"
        },
        {
          "name": "naproxen 500 mg bid",
          "type": "DRUG"
        },
        {
          "name": "ibuprofen 600 mg tid",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NicOx",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2008-03",
      "completion_date": "2008-12",
      "has_results": false,
      "last_update_posted_date": "2011-06-17",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 57,
      "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Sierra Vista, Arizona + 54 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Sierra Vista",
          "state": "Arizona"
        },
        {
          "city": "Carmichael",
          "state": "California"
        },
        {
          "city": "Fair Oaks",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00662896"
    },
    {
      "nct_id": "NCT01999517",
      "title": "Contrast Nephropathy and Nitrates",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Contrast Induced Nephropathy"
      ],
      "interventions": [
        {
          "name": "Intravenous Nitroglycerin",
          "type": "DRUG"
        },
        {
          "name": "IV Fluids",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mt. Sinai Medical Center, Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 122,
      "start_date": "2013-06",
      "completion_date": "2018-06",
      "has_results": true,
      "last_update_posted_date": "2019-10-29",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 1,
      "location_summary": "Miami Beach, Florida",
      "locations": [
        {
          "city": "Miami Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01999517"
    },
    {
      "nct_id": "NCT00608140",
      "title": "Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Mitral Valve Insufficiency",
        "Heart Failure"
      ],
      "interventions": [
        {
          "name": "Surgical mitral valvuloplasty with placement of annular ring (SMVR)",
          "type": "PROCEDURE"
        },
        {
          "name": "Optimal medical therapy (OMT)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2,
      "start_date": "2008-03",
      "completion_date": "2010-03",
      "has_results": true,
      "last_update_posted_date": "2018-04-04",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 8,
      "location_summary": "Atlanta, Georgia • Boston, Massachusetts • Minneapolis, Minnesota + 5 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00608140"
    },
    {
      "nct_id": "NCT04590040",
      "title": "Trial of Nano-hydroxyapatite-Containing Toothpastes for Relief of Dentin Hypersensitivity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dentin Sensitivity"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "OTHER"
        },
        {
          "name": "15% nano-HAP toothpaste",
          "type": "DEVICE"
        },
        {
          "name": "5% KNO3 toothpaste",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "20 Years to 80 Years"
      },
      "enrollment_count": 192,
      "start_date": "2020-07-28",
      "completion_date": "2023-03-01",
      "has_results": true,
      "last_update_posted_date": "2023-08-16",
      "last_synced_at": "2026-09-15T05:38:40.101Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04590040"
    }
  ]
}