{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nitric+Oxide+Gas&page=3",
    "query": {
      "intervention": "Nitric Oxide Gas",
      "page": 3
    },
    "page_size": 10
  },
  "pagination": {
    "page": 3,
    "page_size": 10,
    "total_count": 391,
    "total_pages": 40,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nitric+Oxide+Gas&page=4&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nitric+Oxide+Gas&page=2&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-30T21:07:50.518Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00603720",
      "title": "Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiovascular Diseases"
      ],
      "interventions": [
        {
          "name": "L-NAME",
          "type": "DRUG"
        },
        {
          "name": "L-Arginine",
          "type": "DRUG"
        },
        {
          "name": "Phenylephrine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 54,
      "start_date": "2005-09",
      "completion_date": "2008-06",
      "has_results": true,
      "last_update_posted_date": "2018-09-12",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00603720"
    },
    {
      "nct_id": "NCT01137253",
      "title": "Autonomic Nervous System and Nitric Oxide Interactions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Endothelial Dysfunction"
      ],
      "interventions": [
        {
          "name": "Trimethaphan",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 21,
      "start_date": "2010-06",
      "completion_date": "2017-01",
      "has_results": false,
      "last_update_posted_date": "2018-02-28",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01137253"
    },
    {
      "nct_id": "NCT06213077",
      "title": "The Effects of a Nitrate Supplementation on Erectile Function",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Erectile Dysfunction"
      ],
      "interventions": [
        {
          "name": "Nitric Oxide",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Tadalafil",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "DRUG",
        "OTHER"
      ],
      "sponsor": "RHA Investments Ltd",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "65 Years",
        "sex": "MALE",
        "summary": "40 Years to 65 Years · Male only"
      },
      "enrollment_count": 20,
      "start_date": "2023-12-12",
      "completion_date": "2024-05-30",
      "has_results": false,
      "last_update_posted_date": "2024-01-19",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06213077"
    },
    {
      "nct_id": "NCT01501929",
      "title": "Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Metoprolol succinate",
          "type": "DRUG"
        },
        {
          "name": "Nebivolol",
          "type": "DRUG"
        },
        {
          "name": "Non-invasive measurement of Cardiac Output (CO)",
          "type": "PROCEDURE"
        },
        {
          "name": "Endothelial cell collection",
          "type": "PROCEDURE"
        },
        {
          "name": "Microvascular perfusion assessment using Definity",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 32,
      "start_date": "2010-08",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2018-11-06",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01501929"
    },
    {
      "nct_id": "NCT03459027",
      "title": "Nitrate Supplementation and Muscle Blood Flow",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Vasodilation",
        "Blood Pressure",
        "Active Hyperemia",
        "Aging"
      ],
      "interventions": [
        {
          "name": "Super Beets",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Beetroot powder",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Iowa",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "60 Years to 80 Years"
      },
      "enrollment_count": 10,
      "start_date": "2017-10-10",
      "completion_date": "2018-02-08",
      "has_results": false,
      "last_update_posted_date": "2019-01-09",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03459027"
    },
    {
      "nct_id": "NCT00848731",
      "title": "Phase I Trial of Inhaled Nitric Oxide to Treat Acute Pulmonary Embolism",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Pulmonary Embolism"
      ],
      "interventions": [
        {
          "name": "nitric oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2009-02",
      "completion_date": "2011-05",
      "has_results": false,
      "last_update_posted_date": "2022-04-25",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00848731"
    },
    {
      "nct_id": "NCT00386737",
      "title": "Development of a Breath Analyzer for Asthma Screening",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Asthma"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Ekips Technologies",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "4 Years to 65 Years"
      },
      "enrollment_count": 2000,
      "start_date": "2004-09",
      "completion_date": "2007-02",
      "has_results": false,
      "last_update_posted_date": "2006-10-12",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Norman, Oklahoma",
      "locations": [
        {
          "city": "Norman",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00386737"
    },
    {
      "nct_id": "NCT03203239",
      "title": "Red Light Treatment in Peripheral Artery Disease",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peripheral Artery Disease",
        "Claudication, Intermittent",
        "Vasodilation"
      ],
      "interventions": [
        {
          "name": "Red Light (670 nm energy)",
          "type": "DEVICE"
        },
        {
          "name": "Octafluoropropane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 40,
      "start_date": "2018-01-17",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-01",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03203239"
    },
    {
      "nct_id": "NCT01775865",
      "title": "Targeting Inflammation to Treat Cardiovascular Aging",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Vascular Stiffness",
        "Endothelial Dysfunction",
        "Diastolic Dysfunction"
      ],
      "interventions": [
        {
          "name": "Salsalate",
          "type": "DRUG"
        },
        {
          "name": "Placebo (for salsalate)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Gary L. Pierce",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "18 Years to 79 Years"
      },
      "enrollment_count": 59,
      "start_date": "2012-09",
      "completion_date": "2016-02",
      "has_results": true,
      "last_update_posted_date": "2018-05-31",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01775865"
    },
    {
      "nct_id": "NCT04800692",
      "title": "The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Claudication, Intermittent",
        "Peripheral Artery Disease",
        "Peripheral Vascular Diseases"
      ],
      "interventions": [
        {
          "name": "Tetrahydrobiopterin 10 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Tetrahydrobiopterin 20 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "L-Ascorbate",
          "type": "DRUG"
        },
        {
          "name": "L-Arginine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Louis Messina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2021-06-15",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-15",
      "last_synced_at": "2026-09-30T21:07:50.518Z",
      "location_count": 1,
      "location_summary": "Worcester, Massachusetts",
      "locations": [
        {
          "city": "Worcester",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04800692"
    }
  ]
}