{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-Invasive+Positive+Pressure+Ventilation&page=2", "query": { "intervention": "Non-Invasive Positive Pressure Ventilation", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-Invasive+Positive+Pressure+Ventilation&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-24T13:33:53.083Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00990119", "title": "High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD)", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Pulmonary Disease, Chronic Obstructive", "Respiratory Insufficiency" ], "interventions": [ { "name": "Vapotherm High Flow Therapy", "type": "DEVICE" }, { "name": "Non-invasive positive pressure ventilation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Vapotherm, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 0, "start_date": "2009-09", "completion_date": "2014-04", "has_results": false, "last_update_posted_date": "2020-09-16", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00990119" }, { "nct_id": "NCT05446272", "title": "The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Extubation Failure", "Bronchopulmonary Dysplasia", "Death" ], "interventions": [ { "name": "NIV-NAVA", "type": "DEVICE" }, { "name": "NS-NIPPV", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "0 Days", "maximum_age": "9 Weeks", "sex": "ALL", "summary": "0 Days to 9 Weeks" }, "enrollment_count": 478, "start_date": "2022-08-03", "completion_date": "2027-12-31", "has_results": false, "last_update_posted_date": "2026-06-25", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 17, "location_summary": "Little Rock, Arkansas • Loma Linda, California • San Diego, California + 14 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Loma Linda", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Hollywood", "state": "Florida" }, { "city": "Orlando", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05446272" }, { "nct_id": "NCT01403428", "title": "Non Invasive Positive Pressure Ventilation in Status Asthmaticus", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Status Asthmaticus" ], "interventions": [ { "name": "Noninvasive positive pressure ventilation", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Southern Illinois University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "18 Years", "sex": "ALL", "summary": "1 Year to 18 Years" }, "enrollment_count": 0, "start_date": "2011-06", "completion_date": "2014-03", "has_results": false, "last_update_posted_date": "2014-12-12", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 1, "location_summary": "Springfield, Illinois", "locations": [ { "city": "Springfield", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT01403428" }, { "nct_id": "NCT05848115", "title": "BiPAP in Pediatric Moderate to Severe Asthma Randomized Control Trial", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Asthma in Children" ], "interventions": [ { "name": "Bi-level Positive Airway Pressure", "type": "DEVICE" }, { "name": "Sham Bi-level Positive Airway Pressure", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Colorado, Denver", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "5 Years to 17 Years" }, "enrollment_count": 67, "start_date": "2023-06-23", "completion_date": "2025-07-07", "has_results": false, "last_update_posted_date": "2025-08-21", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 1, "location_summary": "Denver, Colorado", "locations": [ { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05848115" }, { "nct_id": "NCT05440851", "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Respiratory Insufficiency", "Extracorporeal Membrane Oxygenation Complication", "Mechanical Ventilation Pressure High" ], "interventions": [ { "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support", "type": "OTHER" }, { "name": "Lung-Protective Ventilation (LPV)", "type": "OTHER" }, { "name": "Driving Pressure-Limited Ventilation (DPL)", "type": "OTHER" }, { "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)", "type": "OTHER" }, { "name": "Early Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Extended Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Usual care without routine corticosteroids", "type": "DRUG" }, { "name": "Usual care without extending corticosteroids", "type": "DRUG" }, { "name": "Usual care with fludrocortisone", "type": "DRUG" }, { "name": "Usual care without fludrocortisone", "type": "DRUG" }, { "name": "Drug 4 mL:", "type": "DRUG" }, { "name": "Drug 40 mg:", "type": "DRUG" }, { "name": "PEEP-20", "type": "OTHER" }, { "name": "PEEP-AOP", "type": "OTHER" }, { "name": "PEEP-10", "type": "OTHER" }, { "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation", "type": "OTHER" }, { "name": "Electrical impedance tomography (EIT)", "type": "OTHER" }, { "name": "no treatment / intervention arm is involved.", "type": "OTHER" }, { "name": "Usual care", "type": "OTHER" }, { "name": "Early Routine IMT", "type": "OTHER" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "University Health Network, Toronto", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6250, "start_date": "2023-04-30", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-05-07", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 26, "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05440851" }, { "nct_id": "NCT00433212", "title": "Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Respiratory Insufficiency of Prematurity" ], "interventions": [ { "name": "nCPAP", "type": "DEVICE" }, { "name": "NIPPV", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "McMaster University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "28 Days", "sex": "ALL", "summary": "Up to 28 Days" }, "enrollment_count": 1011, "start_date": "2007-04", "completion_date": "2011-12", "has_results": false, "last_update_posted_date": "2014-12-05", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 14, "location_summary": "Washington D.C., District of Columbia • Boston, Massachusetts • Voorhees Township, New Jersey + 6 more", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Voorhees Township", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00433212" }, { "nct_id": "NCT04326270", "title": "Crossover Comparison of Tidal Volume Delivery During Nasal Intermittent Positive Pressure Ventilation in Preterm Infants: Infant Cannula vs. Nasal Continuous Positive Airway Pressure Prongs", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Respiratory Distress Syndrome in Premature Infant" ], "interventions": [ { "name": "Nasal interface", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Arkansas Children's Hospital Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "28 Days", "sex": "ALL", "summary": "Up to 28 Days" }, "enrollment_count": 20, "start_date": "2019-03-07", "completion_date": "2020-06-30", "has_results": false, "last_update_posted_date": "2020-03-30", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 1, "location_summary": "Little Rock, Arkansas", "locations": [ { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04326270" }, { "nct_id": "NCT01363882", "title": "Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "interventions": [ { "name": "Sleep study-guided adjustment of NIV", "type": "OTHER" }, { "name": "Standard initiation of NIV", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Columbia University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 25, "start_date": "2008-02", "completion_date": "2010-07", "has_results": false, "last_update_posted_date": "2020-11-13", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01363882" }, { "nct_id": "NCT04694638", "title": "Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Prone Positioning", "Covid19", "Hypoxemic Respiratory Failure", "ARDS", "Non Invasive Ventilation", "High Flow Nasal Cannulla" ], "interventions": [ { "name": "Body position change", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "110 Years", "sex": "ALL", "summary": "18 Years to 110 Years" }, "enrollment_count": 6, "start_date": "2020-05-21", "completion_date": "2023-05-10", "has_results": false, "last_update_posted_date": "2023-10-05", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT04694638" }, { "nct_id": "NCT06258187", "title": "Pedi-Cap CO2 Detector for Face-mask Ventilation in the Delivery Room", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Neonatal Resuscitation", "Neonatal Disease" ], "interventions": [ { "name": "Pedi-Cap", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Weeks", "maximum_age": null, "sex": "ALL", "summary": "30 Weeks and older" }, "enrollment_count": 632, "start_date": "2024-03-01", "completion_date": "2026-03-30", "has_results": false, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-09-24T13:33:53.083Z", "location_count": 1, "location_summary": "Dallas, Texas", "locations": [ { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06258187" } ] }