{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-Invasive+Ventilation",
    "query": {
      "intervention": "Non-Invasive Ventilation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 228,
    "total_pages": 23,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-Invasive+Ventilation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-06T05:37:48.292Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04035460",
      "title": "A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoxemic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Helmet",
          "type": "DEVICE"
        },
        {
          "name": "High Flow Nasal Oxygen",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Baystate Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2018-06-01",
      "completion_date": "2022-09-30",
      "has_results": false,
      "last_update_posted_date": "2021-07-22",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 1,
      "location_summary": "Springfield, Massachusetts",
      "locations": [
        {
          "city": "Springfield",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04035460"
    },
    {
      "nct_id": "NCT04479358",
      "title": "Low-dose Tocilizumab Versus Standard of Care in Hospitalized Patients With COVID-19",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "COVID-19"
      ],
      "interventions": [
        {
          "name": "Tocilizumab",
          "type": "DRUG"
        },
        {
          "name": "Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 85,
      "start_date": "2020-09-10",
      "completion_date": "2025-02-10",
      "has_results": true,
      "last_update_posted_date": "2026-06-08",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04479358"
    },
    {
      "nct_id": "NCT03840486",
      "title": "Pre-oxygenation With Real Time End-tidal Oxygen Measurements Versus Single Breath Measurements",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Rapid Sequence Intubation"
      ],
      "interventions": [
        {
          "name": "Non-rebreather mask (NRBM)",
          "type": "DEVICE"
        },
        {
          "name": "Non-invasive ventilator mask (NIV)",
          "type": "DEVICE"
        },
        {
          "name": "Nasal cannula EtO2 sensor",
          "type": "DEVICE"
        },
        {
          "name": "Oxygen (NRBM)",
          "type": "DRUG"
        },
        {
          "name": "Oxygen (NIV)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 105,
      "start_date": "2019-09-24",
      "completion_date": "2023-10-20",
      "has_results": true,
      "last_update_posted_date": "2025-06-13",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 2,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03840486"
    },
    {
      "nct_id": "NCT03132428",
      "title": "Registry to Evaluate INOmax in Newborn Babies With Pulmonary Hypertension",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pulmonary Hypertension of Newborn"
      ],
      "interventions": [
        {
          "name": "INOmax",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mallinckrodt",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "27 Weeks",
        "maximum_age": "40 Weeks",
        "sex": "ALL",
        "summary": "27 Weeks to 40 Weeks"
      },
      "enrollment_count": 140,
      "start_date": "2017-07-27",
      "completion_date": "2020-02-11",
      "has_results": false,
      "last_update_posted_date": "2020-06-18",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 30,
      "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Loma Linda, California + 27 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03132428"
    },
    {
      "nct_id": "NCT07123961",
      "title": "Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial",
      "overall_status": "SUSPENDED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome (ARDS)",
        "Ventilator Management",
        "Lung-protective Ventilation",
        "Pediatric Acute Respiratory Distress Syndrome (PARDS)"
      ],
      "interventions": [
        {
          "name": "High Driving Pressure Mechanical Ventilation",
          "type": "OTHER"
        },
        {
          "name": "Low Driving Pressure Mechanical Ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Weeks",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Weeks to 17 Years"
      },
      "enrollment_count": 160,
      "start_date": "2025-11-07",
      "completion_date": "2030-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-14",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07123961"
    },
    {
      "nct_id": "NCT07071350",
      "title": "Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Autonomic Nervous System Disease",
        "Concussive Injury",
        "Mild Traumatic Brain Injury",
        "Post Traumatic Stress Disorder",
        "Persistent Post Concussion Syndrome"
      ],
      "interventions": [
        {
          "name": "HRV Coherence Ratio",
          "type": "OTHER"
        },
        {
          "name": "NSI",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pittsburgh Sleep Quality Index (PSQI)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Quantitative Sleep Measures",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Patient Global Impression of Change (PGIC)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Performance/NIH Toolbox Cognitive Battery",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pain Interference/TBI-QoL Pain Interference Short-Form",
          "type": "OTHER"
        },
        {
          "name": "Patient Health Questionnaire-9 (PHQ-9)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "PTSD Checklist for DSM-5 (PCL-5)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "HRV Biofeedback (HRV-B)",
          "type": "OTHER"
        },
        {
          "name": "Psychoeducational (Edu) Comparator Intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 148,
      "start_date": "2025-09-02",
      "completion_date": "2028-09",
      "has_results": false,
      "last_update_posted_date": "2025-09-17",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07071350"
    },
    {
      "nct_id": "NCT02896751",
      "title": "Use of a 3D Printer to Make Custom Sleep Masks for Positive Airway Pressure Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Apnea",
        "Pediatric Sleep Apnea"
      ],
      "interventions": [
        {
          "name": "3D printed NIV mask",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "5 Years to 25 Years"
      },
      "enrollment_count": 15,
      "start_date": "2016-08",
      "completion_date": "2022-03-07",
      "has_results": false,
      "last_update_posted_date": "2025-10-03",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02896751"
    },
    {
      "nct_id": "NCT04218370",
      "title": "Liberation From Acute Dialysis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Kidney Injury",
        "Kidney; Disease, Acute",
        "Dialysis Related Complication"
      ],
      "interventions": [
        {
          "name": "Dialysis",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 220,
      "start_date": "2020-01-23",
      "completion_date": "2025-06-08",
      "has_results": false,
      "last_update_posted_date": "2025-12-09",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 4,
      "location_summary": "San Francisco, California • St Louis, Missouri • Nashville, Tennessee + 1 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Murray",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04218370"
    },
    {
      "nct_id": "NCT02685930",
      "title": "Pneumonia in the Intensive Care Unit (ICU) Setting",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pneumonia",
        "Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Antibiotic de-escalation by ICU stewardship team with decreased exposure to broad spectrum antibiotics and shorter duration of therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 364,
      "start_date": "2016-01",
      "completion_date": "2017-02-01",
      "has_results": false,
      "last_update_posted_date": "2018-05-08",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02685930"
    },
    {
      "nct_id": "NCT06613438",
      "title": "Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "GERD (Gastroesophageal Reflux Disease)"
      ],
      "interventions": [
        {
          "name": "eGERD device",
          "type": "DEVICE"
        },
        {
          "name": "eGERD_Sham",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Gerd Care Medical Ltd",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "22 Years to 75 Years"
      },
      "enrollment_count": 84,
      "start_date": "2024-09-15",
      "completion_date": "2027-04",
      "has_results": false,
      "last_update_posted_date": "2026-06-23",
      "last_synced_at": "2026-09-06T05:37:48.292Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06613438"
    }
  ]
}