{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-Nutritive+Sweetener",
    "query": {
      "intervention": "Non-Nutritive Sweetener"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 25,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-Nutritive+Sweetener&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-16T09:13:16.648Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01324921",
      "title": "Effect of Nutritional Products on Metabolic Parameters in Subjects With Type 2 Diabetics",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Diabetes Mellitus, Type 2"
      ],
      "interventions": [
        {
          "name": "No breakfast/beverage only",
          "type": "OTHER"
        },
        {
          "name": "Breakfast",
          "type": "OTHER"
        },
        {
          "name": "10004RF",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Abbott Nutrition",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 37,
      "start_date": "2010-08",
      "completion_date": "2010-09",
      "has_results": false,
      "last_update_posted_date": "2011-03-30",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 2,
      "location_summary": "Glen Ellyn, Illinois • Cincinnati, Ohio",
      "locations": [
        {
          "city": "Glen Ellyn",
          "state": "Illinois"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01324921"
    },
    {
      "nct_id": "NCT01200940",
      "title": "Metabolic Effects of Non-Nutritive Sweeteners",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Healthy Volunteers"
      ],
      "interventions": [
        {
          "name": "Sucralose",
          "type": "OTHER"
        },
        {
          "name": "Aspartame",
          "type": "OTHER"
        },
        {
          "name": "Acesulfame-Potassium",
          "type": "OTHER"
        },
        {
          "name": "Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "6 Years and older"
      },
      "enrollment_count": 118,
      "start_date": "2010-11-04",
      "completion_date": "2017-03-30",
      "has_results": false,
      "last_update_posted_date": "2021-01-22",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01200940"
    },
    {
      "nct_id": "NCT03241706",
      "title": "Liver Glycogen and Hypoglycemia in Humans",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hypoglycemia; Iatrogenic"
      ],
      "interventions": [
        {
          "name": "Low Fructose",
          "type": "DRUG"
        },
        {
          "name": "Saline",
          "type": "DRUG"
        },
        {
          "name": "Somatostatin",
          "type": "DRUG"
        },
        {
          "name": "Insulin",
          "type": "DRUG"
        },
        {
          "name": "Glucagon",
          "type": "DRUG"
        },
        {
          "name": "Dextrose solution",
          "type": "DRUG"
        },
        {
          "name": "High Fructose",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Jason Winnick",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "21 Years to 40 Years"
      },
      "enrollment_count": 40,
      "start_date": "2018-08-02",
      "completion_date": "2028-05-31",
      "has_results": false,
      "last_update_posted_date": "2025-07-25",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03241706"
    },
    {
      "nct_id": "NCT05441982",
      "title": "Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Continuous Glucose Monitoring",
        "Oral Glucose Tolerance",
        "Insulin Sensitivity",
        "Inflammatory Markers"
      ],
      "interventions": [
        {
          "name": "Non-Nutritive Sweetener Intake and impact on glucose homeostasis",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Virginia Polytechnic Institute and State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2023-09-21",
      "completion_date": "2026-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-06-10",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Blacksburg, Virginia",
      "locations": [
        {
          "city": "Blacksburg",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05441982"
    },
    {
      "nct_id": "NCT01128829",
      "title": "Sugar-replacement Sweeteners, and Blood Sugar Control",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Water",
          "type": "OTHER"
        },
        {
          "name": "Sucralose",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "21 Years to 40 Years"
      },
      "enrollment_count": 17,
      "start_date": "2010-05",
      "completion_date": "2012-10",
      "has_results": true,
      "last_update_posted_date": "2014-12-22",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01128829"
    },
    {
      "nct_id": "NCT06548828",
      "title": "Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gestational Diabetes Mellitus in Pregnancy",
        "Glucose Intolerance During Pregnancy",
        "Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation"
      ],
      "interventions": [
        {
          "name": "NNS Restriction Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Control Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "George Washington University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 324,
      "start_date": "2024-08-19",
      "completion_date": "2029-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-02-18",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06548828"
    },
    {
      "nct_id": "NCT03579043",
      "title": "The Effects of Beverages on Food Liking",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Nutritive Sweetener",
          "type": "OTHER"
        },
        {
          "name": "Non-Nutritive Sweetener",
          "type": "OTHER"
        },
        {
          "name": "Carbonated Water",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "The University of Tennessee, Knoxville",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 0,
      "start_date": "2018-05-22",
      "completion_date": "2018-09-30",
      "has_results": false,
      "last_update_posted_date": "2018-11-20",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Knoxville, Tennessee",
      "locations": [
        {
          "city": "Knoxville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03579043"
    },
    {
      "nct_id": "NCT06933290",
      "title": "Effect of Flavored, Carbonated Drinks on Salivary Flow, Salivary Composition, and Taste Perceptions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Taste Perception",
        "Saliva Production"
      ],
      "interventions": [
        {
          "name": "Beverage",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "PepsiCo Global R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 13,
      "start_date": "2025-03-24",
      "completion_date": "2025-05-22",
      "has_results": false,
      "last_update_posted_date": "2026-06-30",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Valhalla, New York",
      "locations": [
        {
          "city": "Valhalla",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06933290"
    },
    {
      "nct_id": "NCT02211599",
      "title": "Fat Burning After a Meal",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Postprandial Effect of Carbohydrate Beverage Consumption"
      ],
      "interventions": [
        {
          "name": "15% protein",
          "type": "OTHER"
        },
        {
          "name": "30% protein",
          "type": "OTHER"
        },
        {
          "name": "Sweetened beverage",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "USDA Grand Forks Human Nutrition Research Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 29,
      "start_date": "2014-11",
      "completion_date": "2016-06",
      "has_results": false,
      "last_update_posted_date": "2022-02-02",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Grand Forks, North Dakota",
      "locations": [
        {
          "city": "Grand Forks",
          "state": "North Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02211599"
    },
    {
      "nct_id": "NCT06842693",
      "title": "Testing Non-nutritive Sweetener Labels in Chile",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diet, Healthy"
      ],
      "interventions": [
        {
          "name": "Control",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Chilean non-nutritive sweetener label",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Colombian non-nutritive sweetener label",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 3916,
      "start_date": "2025-07-14",
      "completion_date": "2025-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-09-09",
      "last_synced_at": "2026-09-16T09:13:16.648Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06842693"
    }
  ]
}