{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-invasive+positive+pressure+ventilation",
    "query": {
      "intervention": "Non-invasive positive pressure ventilation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 62,
    "total_pages": 7,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-invasive+positive+pressure+ventilation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-28T00:19:26.678Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00458926",
      "title": "Enhancing Utilization of Non-Invasive Positive Pressure Ventilation in Critical Care",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "COPD",
        "Congestive Heart Failure",
        "Asthma",
        "Respiratory Distress Syndrome, Adult",
        "Pneumonia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Tufts Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 800,
      "start_date": "2003-11",
      "completion_date": "2009-12",
      "has_results": false,
      "last_update_posted_date": "2023-02-03",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00458926"
    },
    {
      "nct_id": "NCT03613987",
      "title": "Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "BPD - Bronchopulmonary Dysplasia"
      ],
      "interventions": [
        {
          "name": "NAVA technology to synchronize NIPPV",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "New York Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Weeks",
        "maximum_age": "30 Weeks",
        "sex": "ALL",
        "summary": "24 Weeks to 30 Weeks"
      },
      "enrollment_count": 60,
      "start_date": "2018-04-26",
      "completion_date": "2022-07-26",
      "has_results": false,
      "last_update_posted_date": "2023-03-27",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Valhalla, New York",
      "locations": [
        {
          "city": "Valhalla",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03613987"
    },
    {
      "nct_id": "NCT06258187",
      "title": "Pedi-Cap CO2 Detector for Face-mask Ventilation in the Delivery Room",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Resuscitation",
        "Neonatal Disease"
      ],
      "interventions": [
        {
          "name": "Pedi-Cap",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Weeks",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Weeks and older"
      },
      "enrollment_count": 632,
      "start_date": "2024-03-01",
      "completion_date": "2026-03-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-02",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06258187"
    },
    {
      "nct_id": "NCT03349437",
      "title": "Vitabreath Pilot in Chronic Obstructive Pulmonary Disease (COPD) Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "COPD",
        "Dyspnea"
      ],
      "interventions": [
        {
          "name": "Vitabreath Device",
          "type": "DEVICE"
        },
        {
          "name": "Pursed Lip Breathing",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Philips Respironics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2017-11-06",
      "completion_date": "2018-02-20",
      "has_results": true,
      "last_update_posted_date": "2019-05-08",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 2,
      "location_summary": "Youngstown, Ohio • Jefferson Hills, Pennsylvania",
      "locations": [
        {
          "city": "Youngstown",
          "state": "Ohio"
        },
        {
          "city": "Jefferson Hills",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03349437"
    },
    {
      "nct_id": "NCT05440851",
      "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Insufficiency",
        "Extracorporeal Membrane Oxygenation Complication",
        "Mechanical Ventilation Pressure High"
      ],
      "interventions": [
        {
          "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support",
          "type": "OTHER"
        },
        {
          "name": "Lung-Protective Ventilation (LPV)",
          "type": "OTHER"
        },
        {
          "name": "Driving Pressure-Limited Ventilation (DPL)",
          "type": "OTHER"
        },
        {
          "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)",
          "type": "OTHER"
        },
        {
          "name": "Early Cohort corticosteroid dose",
          "type": "DRUG"
        },
        {
          "name": "Extended Cohort corticosteroid dose",
          "type": "DRUG"
        },
        {
          "name": "Usual care without routine corticosteroids",
          "type": "DRUG"
        },
        {
          "name": "Usual care without extending corticosteroids",
          "type": "DRUG"
        },
        {
          "name": "Usual care with fludrocortisone",
          "type": "DRUG"
        },
        {
          "name": "Usual care without fludrocortisone",
          "type": "DRUG"
        },
        {
          "name": "Drug 4 mL:",
          "type": "DRUG"
        },
        {
          "name": "Drug 40 mg:",
          "type": "DRUG"
        },
        {
          "name": "PEEP-20",
          "type": "OTHER"
        },
        {
          "name": "PEEP-AOP",
          "type": "OTHER"
        },
        {
          "name": "PEEP-10",
          "type": "OTHER"
        },
        {
          "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation",
          "type": "OTHER"
        },
        {
          "name": "Electrical impedance tomography (EIT)",
          "type": "OTHER"
        },
        {
          "name": "no treatment / intervention arm is involved.",
          "type": "OTHER"
        },
        {
          "name": "Usual care",
          "type": "OTHER"
        },
        {
          "name": "Early Routine IMT",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "University Health Network, Toronto",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6250,
      "start_date": "2023-04-30",
      "completion_date": "2027-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-07",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 26,
      "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05440851"
    },
    {
      "nct_id": "NCT02930174",
      "title": "EIT Assessment of Lung Volume and Tidal Distribution: A Comparison of Non-Invasive Ventilation Devices",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spontaneous Ventilation"
      ],
      "interventions": [
        {
          "name": "noninvasive positive pressure ventilation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2018-02-01",
      "completion_date": "2018-03-27",
      "has_results": true,
      "last_update_posted_date": "2019-05-14",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02930174"
    },
    {
      "nct_id": "NCT03529461",
      "title": "Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Severe Obesity",
        "Hypoxia"
      ],
      "interventions": [
        {
          "name": "Non-invasive positive pressure ventilation through nasal mask",
          "type": "DEVICE"
        },
        {
          "name": "Rescue non-invasive positive pressure ventilation through nasal mask",
          "type": "DEVICE"
        },
        {
          "name": "Secondary rescue maneuvers",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Bristol Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 56,
      "start_date": "2017-04-25",
      "completion_date": "2018-04-18",
      "has_results": true,
      "last_update_posted_date": "2019-05-31",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Bristol, Connecticut",
      "locations": [
        {
          "city": "Bristol",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03529461"
    },
    {
      "nct_id": "NCT03353064",
      "title": "Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypercapnic Respiratory Failure",
        "Chronic Obstructive Pulmonary Disease",
        "Obesity Hypoventilation Syndrome",
        "Sleep Disordered Breathing",
        "Neuromuscular Diseases"
      ],
      "interventions": [
        {
          "name": "Vivify",
          "type": "OTHER"
        },
        {
          "name": "EMS",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Albert Einstein Healthcare Network",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2017-10-18",
      "completion_date": "2018-10-26",
      "has_results": false,
      "last_update_posted_date": "2018-10-29",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03353064"
    },
    {
      "nct_id": "NCT04694638",
      "title": "Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prone Positioning",
        "Covid19",
        "Hypoxemic Respiratory Failure",
        "ARDS",
        "Non Invasive Ventilation",
        "High Flow Nasal Cannulla"
      ],
      "interventions": [
        {
          "name": "Body position change",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "110 Years",
        "sex": "ALL",
        "summary": "18 Years to 110 Years"
      },
      "enrollment_count": 6,
      "start_date": "2020-05-21",
      "completion_date": "2023-05-10",
      "has_results": false,
      "last_update_posted_date": "2023-10-05",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04694638"
    },
    {
      "nct_id": "NCT03180385",
      "title": "NAVA Versus BiPAP Non-Invasive Respiratory Support in Infants Following Congenital Heart Surgery",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Neurally-Adusted Ventilatory Assist (NAVA)",
          "type": "DEVICE"
        },
        {
          "name": "Biphasic Positive Airway Pressure Support (BiPAP)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's Hospitals and Clinics of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "12 Months",
        "sex": "ALL",
        "summary": "Up to 12 Months"
      },
      "enrollment_count": 15,
      "start_date": "2017-03-01",
      "completion_date": "2018-04-10",
      "has_results": true,
      "last_update_posted_date": "2020-03-10",
      "last_synced_at": "2026-09-28T00:19:26.678Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03180385"
    }
  ]
}