{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-invasive+ventilation%28NIV%29&page=4",
    "query": {
      "intervention": "Non-invasive ventilation(NIV)",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 76,
    "total_pages": 8,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-invasive+ventilation%28NIV%29&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Non-invasive+ventilation%28NIV%29&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-06T03:08:46.858Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02865343",
      "title": "Ventilatory Support to Improve Exercise Training in High Level Spinal Cord Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injury"
      ],
      "interventions": [
        {
          "name": "Non-invasive Ventilation(NIV)",
          "type": "DEVICE"
        },
        {
          "name": "Sham Non-invasive ventilation(NIV)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spaulding Rehabilitation Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 11,
      "start_date": "2017-02-22",
      "completion_date": "2019-06-28",
      "has_results": true,
      "last_update_posted_date": "2023-02-09",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 1,
      "location_summary": "Cambridge, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02865343"
    },
    {
      "nct_id": "NCT04206735",
      "title": "The Impact of Interprofessional Training to Improve the Uptake of Noninvasive Ventilation in Patients Hospitalized With Severe COPD Exacerbation",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Copd"
      ],
      "interventions": [
        {
          "name": "Interprofessional Education (IPE)",
          "type": "OTHER"
        },
        {
          "name": "Usual care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Baystate Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "23 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "23 Years to 80 Years"
      },
      "enrollment_count": 0,
      "start_date": "2019-12-08",
      "completion_date": "2022-03-04",
      "has_results": false,
      "last_update_posted_date": "2023-05-23",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 1,
      "location_summary": "Springfield, Massachusetts",
      "locations": [
        {
          "city": "Springfield",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04206735"
    },
    {
      "nct_id": "NCT02523352",
      "title": "Effects of PEEP on Heart and Lungs in Obese Subjects",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Pulmonary Atelectasis",
        "Obesity Hypoventilation Syndrome",
        "Magnetic Resonance Imaging",
        "Respiratory Mechanics",
        "Electrical Impedance Tomography",
        "Trans-Thoracic Echocardiography"
      ],
      "interventions": [
        {
          "name": "Non-Invasive Ventilation",
          "type": "PROCEDURE"
        },
        {
          "name": "Esophageal catheter positioning",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 35,
      "start_date": "2018-04-05",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2020-11-17",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02523352"
    },
    {
      "nct_id": "NCT05446272",
      "title": "The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Extubation Failure",
        "Bronchopulmonary Dysplasia",
        "Death"
      ],
      "interventions": [
        {
          "name": "NIV-NAVA",
          "type": "DEVICE"
        },
        {
          "name": "NS-NIPPV",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Days",
        "maximum_age": "9 Weeks",
        "sex": "ALL",
        "summary": "0 Days to 9 Weeks"
      },
      "enrollment_count": 478,
      "start_date": "2022-08-03",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-25",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 17,
      "location_summary": "Little Rock, Arkansas • Loma Linda, California • San Diego, California + 14 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Hollywood",
          "state": "Florida"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05446272"
    },
    {
      "nct_id": "NCT03680495",
      "title": "Steroid Resistance During COPD Exacerbations With Respiratory Failure",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "COPD",
        "Emphysema or COPD",
        "COPD Exacerbation",
        "COPD Exacerbation Acute",
        "Respiratory Failure",
        "Ventilatory Failure"
      ],
      "interventions": [
        {
          "name": "Methylprednisolone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "40 Years to 89 Years"
      },
      "enrollment_count": 46,
      "start_date": "2017-07-21",
      "completion_date": "2021-01",
      "has_results": false,
      "last_update_posted_date": "2020-01-18",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03680495"
    },
    {
      "nct_id": "NCT01925534",
      "title": "Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Failure",
        "Treatment With Noninvasive Positive Pressure Ventilation"
      ],
      "interventions": [
        {
          "name": "High-flow humidified nasal oxygen delivery system",
          "type": "DEVICE"
        },
        {
          "name": "Standard oxygen therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Tufts Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 47,
      "start_date": "2013-11",
      "completion_date": "2016-12",
      "has_results": true,
      "last_update_posted_date": "2024-07-03",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Winchester, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Winchester",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01925534"
    },
    {
      "nct_id": "NCT04326270",
      "title": "Crossover Comparison of Tidal Volume Delivery During Nasal Intermittent Positive Pressure Ventilation in Preterm Infants: Infant Cannula vs. Nasal Continuous Positive Airway Pressure Prongs",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Distress Syndrome in Premature Infant"
      ],
      "interventions": [
        {
          "name": "Nasal interface",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Arkansas Children's Hospital Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "28 Days",
        "sex": "ALL",
        "summary": "Up to 28 Days"
      },
      "enrollment_count": 20,
      "start_date": "2019-03-07",
      "completion_date": "2020-06-30",
      "has_results": false,
      "last_update_posted_date": "2020-03-30",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 1,
      "location_summary": "Little Rock, Arkansas",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04326270"
    },
    {
      "nct_id": "NCT06560411",
      "title": "Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obstructive Sleep Apnea",
        "Obesity Hypoventilation Syndrome (OHS)",
        "Chronic Obstructive Pulmonary Disease (COPD)",
        "Neuromuscular Diseases (NMD)"
      ],
      "interventions": [
        {
          "name": "Non-Invasive Ventilation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Breas Medical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 23,
      "start_date": "2024-10-03",
      "completion_date": "2025-08-07",
      "has_results": false,
      "last_update_posted_date": "2026-01-28",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 4,
      "location_summary": "Scottsdale, Arizona • San Diego, California • Colorado Springs, Colorado + 1 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Colorado Springs",
          "state": "Colorado"
        },
        {
          "city": "Columbia",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06560411"
    },
    {
      "nct_id": "NCT03298035",
      "title": "A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Apnea of Prematurity"
      ],
      "interventions": [
        {
          "name": "NCPAP as mode for apnea prevention",
          "type": "DEVICE"
        },
        {
          "name": "NIPPV as rescue mode for apnea prevention",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 19,
      "start_date": "2017-11-11",
      "completion_date": "2018-12-31",
      "has_results": true,
      "last_update_posted_date": "2020-02-07",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03298035"
    },
    {
      "nct_id": "NCT02114944",
      "title": "Treatment of Dyspnea in Do-not-intubate Patients",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Respiratory Failure",
        "Acute on Chronic Respiratory Failure",
        "Dyspnea"
      ],
      "interventions": [
        {
          "name": "NIV",
          "type": "DEVICE"
        },
        {
          "name": "CPAP",
          "type": "DEVICE"
        },
        {
          "name": "Standard oxygen",
          "type": "DEVICE"
        },
        {
          "name": "HFNC",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Tufts Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 400,
      "start_date": "2014-04",
      "completion_date": "2023-12-01",
      "has_results": false,
      "last_update_posted_date": "2025-05-13",
      "last_synced_at": "2026-10-06T03:08:46.858Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02114944"
    }
  ]
}