{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=OFF+Dopaminergic+Medication", "query": { "intervention": "OFF Dopaminergic Medication" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 13, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=OFF+Dopaminergic+Medication&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-19T11:16:34.731Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05022147", "title": "Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Parkinson Disease", "Gait Disorders, Neurologic", "Disease Progression", "Subthalamic Nucleus", "Accidental Fall", "Deep Brain Stimulation" ], "interventions": [ { "name": "High-Frequency-Only Stimulation", "type": "DEVICE" }, { "name": "Low-Frequency-Only Stimulation", "type": "DEVICE" }, { "name": "Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation", "type": "DEVICE" }, { "name": "Alternating, 50 sec High-Frequency, 50 sec Low-Frequency Stimulation", "type": "DEVICE" }, { "name": "Alternating, 10 sec High-Frequency, 50 sec Low-Frequency Stimulation", "type": "DEVICE" }, { "name": "Alternating, 10 sec High-Frequency, 10 sec Low-Frequency Stimulation", "type": "DEVICE" }, { "name": "OFF Dopaminergic Medication", "type": "DRUG" }, { "name": "ON Dopaminergic Medication", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "James Liao", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 12, "start_date": "2021-10-04", "completion_date": "2026-12", "has_results": false, "last_update_posted_date": "2026-07-01", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT05022147" }, { "nct_id": "NCT04922593", "title": "Relative Bioavailability of LY03010 Compared to Listed Drug", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia", "Psychotic Disorders", "Mood Disorders", "Schizophrenia Spectrum", "Mental Disorders", "Antipsychotic Agents", "Tranquilizing Agents", "Central Nervous System Depressants", "Physiological Effects of Drugs", "Psychotropic Drugs", "Neurotransmitter Agents", "Molecular Mechanisms of Pharmacological Action" ], "interventions": [ { "name": "LY03010; paliperidone palmitate", "type": "DRUG" }, { "name": "INVEGA SUSTENNA", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Luye Pharma Group Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 281, "start_date": "2021-01-13", "completion_date": "2022-04-15", "has_results": false, "last_update_posted_date": "2023-04-25", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 9, "location_summary": "Garden Grove, California • Lemon Grove, California • Torrance, California + 6 more", "locations": [ { "city": "Garden Grove", "state": "California" }, { "city": "Lemon Grove", "state": "California" }, { "city": "Torrance", "state": "California" }, { "city": "Miami Lakes", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04922593" }, { "nct_id": "NCT05608915", "title": "External vs Internal-triggered Augmented-reality Visual Cues to Treat Freezing of Gait", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Parkinson Disease", "Gait Disorders, Neurologic", "Parkinsonian Disorders", "Movement Disorders", "Gait, Unsteady", "Gait, Festinating" ], "interventions": [ { "name": "No Cue", "type": "OTHER" }, { "name": "Conventional Cue", "type": "OTHER" }, { "name": "Constant Cue", "type": "OTHER" }, { "name": "Patient hand-triggered", "type": "OTHER" }, { "name": "Patient eye-triggered", "type": "OTHER" }, { "name": "Examiner-triggered", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 36, "start_date": "2022-11-17", "completion_date": "2023-07-28", "has_results": false, "last_update_posted_date": "2023-12-18", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT05608915" }, { "nct_id": "NCT02600858", "title": "Exogenous Effects of Standard Medical Care (Dopamine) on Motor Learning of an Upper Limb Task in Parkinson Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "Upper limb feeding training", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of Utah", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "50 Years to 80 Years" }, "enrollment_count": 23, "start_date": "2016-01", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2018-02-22", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT02600858" }, { "nct_id": "NCT05321602", "title": "Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia", "Psychotic Disorders", "Mood Disorders", "Schizophrenia Spectrum and Other Psychotic Disorders", "Mental Disorders", "Antipsychotic Agents", "Tranquilizing Agents", "Central Nervous System Depression", "Physiological Effects of Drugs", "Psychotropic Drugs", "Neurotransmitter Agents", "Molecular Mechanisms of Pharmacological Action" ], "interventions": [ { "name": "LY03010 156 mg treatment group, deltoid", "type": "DRUG" }, { "name": "LY03010 156 mg treatment group, gluteal", "type": "DRUG" }, { "name": "LY03010 351 mg treatment group, deltoid", "type": "DRUG" }, { "name": "LY03010 351 mg treatment group, gluteal", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Luye Pharma Group Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 89, "start_date": "2021-09-08", "completion_date": "2022-10-23", "has_results": false, "last_update_posted_date": "2024-03-19", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 9, "location_summary": "Little Rock, Arkansas • Garden Grove, California • Orange, California + 6 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Garden Grove", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Torrance", "state": "California" }, { "city": "Miami Lakes", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05321602" }, { "nct_id": "NCT06618157", "title": "Connectomic Guided DBS for Parkinson's Disease", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Parkinson Disease", "Tremor", "Dyskinesias" ], "interventions": [ { "name": "Cerebellothalamic optimized deep brain stimulation", "type": "DEVICE" }, { "name": "Pallidothalamic optimized deep brain stimulation", "type": "DEVICE" }, { "name": "No deep brain stimulation", "type": "OTHER" }, { "name": "Usual care deep brain stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2026-02-16", "completion_date": "2027-01-29", "has_results": false, "last_update_posted_date": "2026-09-03", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT06618157" }, { "nct_id": "NCT03647137", "title": "Amyloidopathy, Cholinopathy, Dopamine Responsiveness and Freezing of Gait in PD", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Parkinson's Disease" ], "interventions": [ { "name": "Detailed motor testing, including FoG, in PD subjects", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 53, "start_date": "2016-06-07", "completion_date": "2021-05-26", "has_results": true, "last_update_posted_date": "2024-01-05", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT03647137" }, { "nct_id": "NCT00762814", "title": "The Use of Sensory or Motor Cues Using Electrical Stimulation to Reduce Gait Freezing in Patients With Parkinson Disease", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "Gait tests with and without the use of a tactile sensory cue (electrical stimulation using a TENS unit)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "50 Years to 80 Years" }, "enrollment_count": 4, "start_date": "2008-05", "completion_date": "2009-06", "has_results": false, "last_update_posted_date": "2018-05-11", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT00762814" }, { "nct_id": "NCT06688357", "title": "Revitalize Cognition: Near Infrared Stimulation in Parkinson Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "Active NIR-PBM (MedX 1116, MCT502)", "type": "DEVICE" }, { "name": "Sham NIR-PBM (MedX 1116, MCT502)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "62 Years", "maximum_age": "89 Years", "sex": "ALL", "summary": "62 Years to 89 Years" }, "enrollment_count": 23, "start_date": "2019-06-26", "completion_date": "2022-08-15", "has_results": true, "last_update_posted_date": "2025-02-17", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06688357" }, { "nct_id": "NCT06586320", "title": "Quantification of Parkinson's Disease Patients As a Biomarker for Classification, Prediction and Response to Treatment", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "150% of their routine home dopaminergic medications dose right in the clinic", "type": "DRUG" }, { "name": "Evaluation of mathematical models", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Stardots AB", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2025-02-06", "completion_date": "2027-02-01", "has_results": false, "last_update_posted_date": "2025-02-20", "last_synced_at": "2026-09-19T11:16:34.731Z", "location_count": 1, "location_summary": "Manchester, New Hampshire", "locations": [ { "city": "Manchester", "state": "New Hampshire" } ], "official_url": "https://clinicaltrials.gov/study/NCT06586320" } ] }