{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=OPTI-FREE+RepleniSH",
    "query": {
      "intervention": "OPTI-FREE RepleniSH"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 18,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=OPTI-FREE+RepleniSH&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-04T09:31:02.109Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01250925",
      "title": "Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Myopia",
        "Refractive Error"
      ],
      "interventions": [
        {
          "name": "ReNu MultiPlus® MultiPurpose Solution",
          "type": "DRUG"
        },
        {
          "name": "OPTI-FREE® RepleniSH®",
          "type": "DRUG"
        },
        {
          "name": "Clear Care®",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts Eye and Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 94,
      "start_date": "2010-08",
      "completion_date": "2012-07",
      "has_results": true,
      "last_update_posted_date": "2017-01-10",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 2,
      "location_summary": "Iowa City, Iowa • Boston, Massachusetts",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01250925"
    },
    {
      "nct_id": "NCT04702984",
      "title": "Clinical Characterization of an Investigational Frequent Replacement Daily Wear Silicone Hydrogel Sphere Contact Lens",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Refractive Errors"
      ],
      "interventions": [
        {
          "name": "LID021201 contact lenses",
          "type": "DEVICE"
        },
        {
          "name": "OPTI-FREE multipurpose solution",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 39,
      "start_date": "2021-01-21",
      "completion_date": "2021-02-26",
      "has_results": true,
      "last_update_posted_date": "2022-03-16",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 3,
      "location_summary": "Maitland, Florida • Memphis, Tennessee • Wichita Falls, Texas",
      "locations": [
        {
          "city": "Maitland",
          "state": "Florida"
        },
        {
          "city": "Memphis",
          "state": "Tennessee"
        },
        {
          "city": "Wichita Falls",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04702984"
    },
    {
      "nct_id": "NCT04789382",
      "title": "Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Refractive Errors"
      ],
      "interventions": [
        {
          "name": "LID018869+RepleniSH",
          "type": "DEVICE"
        },
        {
          "name": "LID018869+Biotrue",
          "type": "DEVICE"
        },
        {
          "name": "Biofinity+RepleniSH",
          "type": "DEVICE"
        },
        {
          "name": "PV+Biotrue",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 36,
      "start_date": "2021-04-07",
      "completion_date": "2021-05-07",
      "has_results": true,
      "last_update_posted_date": "2022-05-25",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 1,
      "location_summary": "Maitland, Florida",
      "locations": [
        {
          "city": "Maitland",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04789382"
    },
    {
      "nct_id": "NCT00724269",
      "title": "Comparison of OPTI-FREE RepleniSH and ReNu Multi-Plus Lens Care Regimens on Corneal Epithelium",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Contact Lens Wear"
      ],
      "interventions": [
        {
          "name": "OPTI-FREE RepleniSH",
          "type": "DEVICE"
        },
        {
          "name": "ReNu MultiPlus MPS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2009-10",
      "completion_date": "2011-07",
      "has_results": false,
      "last_update_posted_date": "2012-10-01",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 1,
      "location_summary": "Fort Worth, Texas",
      "locations": [
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00724269"
    },
    {
      "nct_id": "NCT00961051",
      "title": "Evaluation of an Investigational Multi-Purpose Solution (MPS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Study Focus is Healthy Contact Lens Wearers"
      ],
      "interventions": [
        {
          "name": "Investigational MPS",
          "type": "DEVICE"
        },
        {
          "name": "Opti-Free",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Optics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 270,
      "start_date": "2009-02",
      "completion_date": "2009-11",
      "has_results": true,
      "last_update_posted_date": "2014-01-07",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 9,
      "location_summary": "San Diego, California • Waipahu, Hawaii • Warrensburg, Missouri + 6 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Waipahu",
          "state": "Hawaii"
        },
        {
          "city": "Warrensburg",
          "state": "Missouri"
        },
        {
          "city": "Athens",
          "state": "Ohio"
        },
        {
          "city": "Beachwood",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00961051"
    },
    {
      "nct_id": "NCT01100424",
      "title": "Assessment of Tear Film-Based Proteins Associated With Care Solution Induced Corneal Staining",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Corneal Staining"
      ],
      "interventions": [
        {
          "name": "Opti-Free RepleniSH",
          "type": "DEVICE"
        },
        {
          "name": "ReNu MultiPlus",
          "type": "DEVICE"
        },
        {
          "name": "Balafilcon A",
          "type": "DEVICE"
        },
        {
          "name": "Unisol 4",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 60,
      "start_date": "2010-03",
      "completion_date": "2010-09",
      "has_results": false,
      "last_update_posted_date": "2012-10-23",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 1,
      "location_summary": "Fort Worth, Texas",
      "locations": [
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01100424"
    },
    {
      "nct_id": "NCT00804999",
      "title": "Two Phase Clinical Study of the Impact of Contact Lenses and Solutions on Corneal Structure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Normal Contact Lens Wear"
      ],
      "interventions": [
        {
          "name": "Clear Care",
          "type": "DRUG"
        },
        {
          "name": "ReNu",
          "type": "DRUG"
        },
        {
          "name": "OPTI-FREE",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Christine Sindt",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 51,
      "start_date": "2008-11-01",
      "completion_date": "2009-03-01",
      "has_results": true,
      "last_update_posted_date": "2018-01-23",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00804999"
    },
    {
      "nct_id": "NCT01024855",
      "title": "Comparative Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Myopia",
        "Hyperopia",
        "Astigmatism"
      ],
      "interventions": [
        {
          "name": "RevitaLens OcuTec MPS (Investigational MPS) and Opti-Free RepleniSH MPS (control)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Optics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 30,
      "start_date": "2009-04",
      "completion_date": "2009-06",
      "has_results": true,
      "last_update_posted_date": "2015-10-20",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 1,
      "location_summary": "Santa Ana, California",
      "locations": [
        {
          "city": "Santa Ana",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01024855"
    },
    {
      "nct_id": "NCT00772707",
      "title": "A Multi-Center Investigation of Patient Acceptability of OPTI-FREE RepleniSH® Multi-Purpose Disinfecting Solution (MPDS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myopia"
      ],
      "interventions": [
        {
          "name": "Multi-Purpose Disinfecting Solution (OPTI-FREE RepleniSH)",
          "type": "DEVICE"
        },
        {
          "name": "Contact Lenses",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 114,
      "start_date": "2008-09",
      "completion_date": "2008-10",
      "has_results": true,
      "last_update_posted_date": "2012-09-07",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 1,
      "location_summary": "Fort Worth, Texas",
      "locations": [
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00772707"
    },
    {
      "nct_id": "NCT01211535",
      "title": "Subjective Comfort With Multipurpose Care Solutions in Soft Contact Lens Wearers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myopia",
        "Astigmatism",
        "Refractive Error"
      ],
      "interventions": [
        {
          "name": "OPTI-FREE RepleniSH multipurpose solution",
          "type": "DEVICE"
        },
        {
          "name": "ReNu Biotrue multipurpose solution",
          "type": "DEVICE"
        },
        {
          "name": "Silicone hydrogel contact lenses",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 104,
      "start_date": "2010-09",
      "completion_date": "2010-11",
      "has_results": true,
      "last_update_posted_date": "2012-11-12",
      "last_synced_at": "2026-09-04T09:31:02.109Z",
      "location_count": 1,
      "location_summary": "Fort Worth, Texas",
      "locations": [
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01211535"
    }
  ]
}