{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=OPTIMAL&page=26",
    "query": {
      "intervention": "OPTIMAL",
      "page": 26
    },
    "page_size": 10
  },
  "pagination": {
    "page": 26,
    "page_size": 10,
    "total_count": 1444,
    "total_pages": 145,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=OPTIMAL&page=27&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=OPTIMAL&page=25&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-31T00:09:00.089Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06552637",
      "title": "Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Heart Failure With Reduced Ejection Fraction"
      ],
      "interventions": [
        {
          "name": "Synchronized Diaphragmatic Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VisCardia Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 270,
      "start_date": "2026-07-08",
      "completion_date": "2029-12",
      "has_results": false,
      "last_update_posted_date": "2026-10-23",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 4,
      "location_summary": "Indianapolis, Indiana • Tulsa, Oklahoma • Philadelphia, Pennsylvania + 1 more",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Tulsa",
          "state": "Oklahoma"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06552637"
    },
    {
      "nct_id": "NCT03334266",
      "title": "Preventing Early Childhood Obesity, Part 2: Family Spirit Nurture, Prenatal - 18 Months",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Infant Obesity",
        "Mother-Child Relations",
        "Dietary Habits",
        "Breast Feeding",
        "Physical Activity",
        "Childhood Obesity",
        "Feeding Behavior"
      ],
      "interventions": [
        {
          "name": "Family Spirit Nurture (FSN)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Injury Prevention Education (IPE)",
          "type": "OTHER"
        },
        {
          "name": "Optimized Standard Care (OSC)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Johns Hopkins Bloomberg School of Public Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "24 Years",
        "sex": "FEMALE",
        "summary": "14 Years to 24 Years · Female only"
      },
      "enrollment_count": 259,
      "start_date": "2017-09-25",
      "completion_date": "2023-02-28",
      "has_results": false,
      "last_update_posted_date": "2023-03-06",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 3,
      "location_summary": "Fort Defiance, Arizona • Whiteriver, Arizona • Shiprock, New Mexico",
      "locations": [
        {
          "city": "Fort Defiance",
          "state": "Arizona"
        },
        {
          "city": "Whiteriver",
          "state": "Arizona"
        },
        {
          "city": "Shiprock",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03334266"
    },
    {
      "nct_id": "NCT06159231",
      "title": "FAME II-10-year Follow-Up",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "CoreAalst BV",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 888,
      "start_date": "2023-04-25",
      "completion_date": "2024-05-15",
      "has_results": false,
      "last_update_posted_date": "2025-01-07",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 3,
      "location_summary": "Stanford, California • Decatur, Georgia • Bangor, Maine",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Decatur",
          "state": "Georgia"
        },
        {
          "city": "Bangor",
          "state": "Maine"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06159231"
    },
    {
      "nct_id": "NCT00971386",
      "title": "Short Term Hemodynamic Effects of Controlled Slow Breathing With Biofeedback in Patients With Heart Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Heart Failure"
      ],
      "interventions": [
        {
          "name": "Slow breathing",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Albert Einstein Healthcare Network",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 11,
      "start_date": "2008-02",
      "completion_date": "2009-10",
      "has_results": false,
      "last_update_posted_date": "2011-05-10",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00971386"
    },
    {
      "nct_id": "NCT06879054",
      "title": "Lifestyle, Education, Activity, Nutrition (LEAN) Into Pregnancy",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pregnancy",
        "Preconception Education",
        "Preconception Care, Preconception Risk",
        "Adverse Pregnancy Outcomes"
      ],
      "interventions": [
        {
          "name": "Healthy lifestyle education",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 35 Years · Female only"
      },
      "enrollment_count": 200,
      "start_date": "2026-07-01",
      "completion_date": "2029-09",
      "has_results": false,
      "last_update_posted_date": "2026-03-12",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06879054"
    },
    {
      "nct_id": "NCT04136951",
      "title": "Improving Patient Prioritization During Hospital-homecare Transition",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes Mellitus, Type 2",
        "Congestive Heart Failure",
        "Obstructive Pulmonary Disease",
        "Dyspnea",
        "Renal Failure"
      ],
      "interventions": [
        {
          "name": "PREVENT clinical decision support",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1915,
      "start_date": "2023-08-01",
      "completion_date": "2024-05-01",
      "has_results": true,
      "last_update_posted_date": "2025-10-08",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 2,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04136951"
    },
    {
      "nct_id": "NCT01125423",
      "title": "Study of Fibromyalgia Treated With Milnacipran",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Fibromyalgia"
      ],
      "interventions": [
        {
          "name": "Milnacipran",
          "type": "DRUG"
        },
        {
          "name": "Skin Biopsy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Albany Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 70 Years · Female only"
      },
      "enrollment_count": 27,
      "start_date": "2010-05",
      "completion_date": "2013-01",
      "has_results": false,
      "last_update_posted_date": "2020-01-09",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 1,
      "location_summary": "Albany, New York",
      "locations": [
        {
          "city": "Albany",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01125423"
    },
    {
      "nct_id": "NCT05900986",
      "title": "LS301-IT in Partial Mastectomy and Sentinel Lymph Node Biopsy (SLNB) for DCIS or Stage I-II Primary Invasive Breast Cancer",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Breast Cancer",
        "DCIS",
        "Invasive Duct Carcinoma of Breast"
      ],
      "interventions": [
        {
          "name": "LS301-IT 0.025 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "LS301-IT 0.05 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "LS301-IT 0.075 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "LS301-IT 0.1 mg/kg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Integro Theranostics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 80 Years · Female only"
      },
      "enrollment_count": 22,
      "start_date": "2023-07-14",
      "completion_date": "2026-05-06",
      "has_results": false,
      "last_update_posted_date": "2026-05-20",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 9,
      "location_summary": "Scottsdale, Arizona • Washington D.C., District of Columbia • Weston, Florida + 6 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Weston",
          "state": "Florida"
        },
        {
          "city": "The Bronx",
          "state": "New York"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05900986"
    },
    {
      "nct_id": "NCT02871752",
      "title": "Reducing the Effects of Active Surveillance Stress, Uncertainty and Rumination Thru Engagement in Mindfulness Education",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prostate Cancer"
      ],
      "interventions": [
        {
          "name": "Health promotion",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 225,
      "start_date": "2016-08-10",
      "completion_date": "2023-01-30",
      "has_results": false,
      "last_update_posted_date": "2023-03-13",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 4,
      "location_summary": "Chicago, Illinois • Evanston, Illinois • Ann Arbor, Michigan + 1 more",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Evanston",
          "state": "Illinois"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02871752"
    },
    {
      "nct_id": "NCT04084093",
      "title": "Evaluating the Use of a Concentrated Surfactant Gel in Burn Patients",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Burns"
      ],
      "interventions": [
        {
          "name": "Surfactant Gel",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medline Industries",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2020-02-12",
      "completion_date": "2020-04-08",
      "has_results": false,
      "last_update_posted_date": "2020-04-20",
      "last_synced_at": "2026-10-31T00:09:00.089Z",
      "location_count": 2,
      "location_summary": "Maywood, Illinois • Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Maywood",
          "state": "Illinois"
        },
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04084093"
    }
  ]
}