{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Off-loading&page=3",
    "query": {
      "intervention": "Off-loading",
      "page": 3
    },
    "page_size": 10
  },
  "pagination": {
    "page": 3,
    "page_size": 10,
    "total_count": 114,
    "total_pages": 12,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Off-loading&page=4&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Off-loading&page=2&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-21T12:22:26.157Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06437028",
      "title": "Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Foot Ulcer"
      ],
      "interventions": [
        {
          "name": "Dual-layer perinatal tissue allograft",
          "type": "OTHER"
        },
        {
          "name": "Three-layer fenestrated perinatal tissue allograft",
          "type": "OTHER"
        },
        {
          "name": "Standard of care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Samaritan Biologics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 170,
      "start_date": "2025-05-09",
      "completion_date": "2027-03",
      "has_results": false,
      "last_update_posted_date": "2026-09-02",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 1,
      "location_summary": "Monroe, North Carolina",
      "locations": [
        {
          "city": "Monroe",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06437028"
    },
    {
      "nct_id": "NCT06444841",
      "title": "Paper-Based and Smartphone-Based Memory Supports",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alzheimer Disease",
        "Dementia, Mild",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Digital - Google Calendar",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Paper-based - Memory Support System",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Baylor University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2024-06-27",
      "completion_date": "2028-09-30",
      "has_results": false,
      "last_update_posted_date": "2024-07-09",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 3,
      "location_summary": "Austin, Texas • Temple, Texas • Waco, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        },
        {
          "city": "Temple",
          "state": "Texas"
        },
        {
          "city": "Waco",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06444841"
    },
    {
      "nct_id": "NCT02675855",
      "title": "GrafixPRIME® for the Treatment of Chronic Diabetic Foot Ulcers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Foot Ulcer, Diabetic"
      ],
      "interventions": [
        {
          "name": "GrafixPRIME®",
          "type": "OTHER"
        },
        {
          "name": "Dressing Application",
          "type": "PROCEDURE"
        },
        {
          "name": "Off-loading (walking boot)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Osiris Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 75,
      "start_date": "2016-01",
      "completion_date": "2017-07",
      "has_results": false,
      "last_update_posted_date": "2017-07-17",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 3,
      "location_summary": "Arizona City, Arizona • California City, California • New Mexico, New Mexico",
      "locations": [
        {
          "city": "Arizona City",
          "state": "Arizona"
        },
        {
          "city": "California City",
          "state": "California"
        },
        {
          "city": "New Mexico",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02675855"
    },
    {
      "nct_id": "NCT07089602",
      "title": "Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Diabetic Foot",
        "DFU",
        "Diabetic Foot Ulcer",
        "Foot Ulcer, Diabetic",
        "Ulcer Foot",
        "Venous Leg Ulcer",
        "Leg Ulcer",
        "Leg Ulcers Venous",
        "Ulcer"
      ],
      "interventions": [
        {
          "name": "Standard of Care DFU",
          "type": "OTHER"
        },
        {
          "name": "Tri-Membrane Wrap™ DFU",
          "type": "OTHER"
        },
        {
          "name": "Membrane Wrap™ DFU",
          "type": "OTHER"
        },
        {
          "name": "Membrane Wrap-Lite™ DFU",
          "type": "OTHER"
        },
        {
          "name": "Membrane Wrap-Hydro™ DFU",
          "type": "OTHER"
        },
        {
          "name": "Standard of Care VLU",
          "type": "OTHER"
        },
        {
          "name": "Tri-Membrane Wrap™ VLU",
          "type": "OTHER"
        },
        {
          "name": "Membrane Wrap™ VLU",
          "type": "OTHER"
        },
        {
          "name": "Membrane Wrap-Lite™ VLU",
          "type": "OTHER"
        },
        {
          "name": "Membrane Wrap-Hydro™ VLU",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "BioLab Holdings",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 650,
      "start_date": "2025-07-15",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2025-07-28",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 1,
      "location_summary": "Philidelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philidelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07089602"
    },
    {
      "nct_id": "NCT02667327",
      "title": "A Study of Granexin Gel in the Treatment of Diabetic Foot Ulcer",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Diabetic Foot Ulcers"
      ],
      "interventions": [
        {
          "name": "Granexin gel",
          "type": "DRUG"
        },
        {
          "name": "Vehicle gel",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Xequel Bio, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 124,
      "start_date": "2018-11-21",
      "completion_date": "2020-05-27",
      "has_results": false,
      "last_update_posted_date": "2020-05-29",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 6,
      "location_summary": "Los Angeles, California • Doral, Florida • Hialeah, Florida + 3 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Doral",
          "state": "Florida"
        },
        {
          "city": "Hialeah",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02667327"
    },
    {
      "nct_id": "NCT05011422",
      "title": "Haploidentical Hematopoietic Stem Cell Transplantation With Ex Vivo TCR Alpha/Beta and CD19 Depletion in Pediatric Hematologic Malignancies",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Pediatric Hematologic Malignancies"
      ],
      "interventions": [
        {
          "name": "Ex Vivo T-cell receptor alpha-beta and CD19+ Depletion using CliniMACs Plus",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "Up to 30 Years"
      },
      "enrollment_count": 50,
      "start_date": "2022-11-03",
      "completion_date": "2029-05-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05011422"
    },
    {
      "nct_id": "NCT01307891",
      "title": "Abraxane With or Without Tigatuzumab in Patients With Metastatic, Triple Negative Breast Cancer",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Breast Cancer",
        "Triple Negative Breast Cancer",
        "Stage IV Breast Cancer",
        "Metastatic Breast Cancer"
      ],
      "interventions": [
        {
          "name": "Abraxane alone",
          "type": "DRUG"
        },
        {
          "name": "Abraxane + Tigatuzumab",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 64,
      "start_date": "2011-03",
      "completion_date": "2017-06",
      "has_results": true,
      "last_update_posted_date": "2017-10-26",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 10,
      "location_summary": "Birmingham, Alabama • Washington D.C., District of Columbia • Chicago, Illinois + 7 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01307891"
    },
    {
      "nct_id": "NCT01584518",
      "title": "B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fluid Over-load"
      ],
      "interventions": [
        {
          "name": "Furosemide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Creighton University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2012-07",
      "completion_date": "2013-06",
      "has_results": true,
      "last_update_posted_date": "2016-05-27",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 1,
      "location_summary": "Omaha, Nebraska",
      "locations": [
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01584518"
    },
    {
      "nct_id": "NCT01608776",
      "title": "RESPOND Restoring Equilibrium and Wound Stimulation to Promote Healing Of Non-healing DFUs",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Diabetic Foot Ulcer"
      ],
      "interventions": [
        {
          "name": "MIST Therapy",
          "type": "DEVICE"
        },
        {
          "name": "SOC - Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Celleration, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 13,
      "start_date": "2012-05",
      "completion_date": "2013-03",
      "has_results": false,
      "last_update_posted_date": "2014-10-08",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01608776"
    },
    {
      "nct_id": "NCT04177082",
      "title": "Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Keratoconus",
        "Pellucid Marginal Corneal Degeneration",
        "Corneal Degeneration",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "PXL-330 Platinum device for crosslinking with Peschke riboflavin solution",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Cornea Associates of Texas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2020-01-10",
      "completion_date": "2022-05-05",
      "has_results": false,
      "last_update_posted_date": "2022-10-19",
      "last_synced_at": "2026-10-21T12:22:26.157Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04177082"
    }
  ]
}