{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=One+night+of+Total+Sleep+Deprivation",
    "query": {
      "intervention": "One night of Total Sleep Deprivation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 9,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-27T08:38:48.188Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05519644",
      "title": "Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Deprivation"
      ],
      "interventions": [
        {
          "name": "Sleep Deprivation",
          "type": "OTHER"
        },
        {
          "name": "Heart Rate",
          "type": "OTHER"
        },
        {
          "name": "Sleep Monitoring",
          "type": "OTHER"
        },
        {
          "name": "Diet",
          "type": "OTHER"
        },
        {
          "name": "Exercise Performance",
          "type": "OTHER"
        },
        {
          "name": "Surveys, McGill Pain Questionnaire, Shortened Profile of Mood States, Pittsburg Sleep Index",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive performance",
          "type": "OTHER"
        },
        {
          "name": "Marksmanship Performance",
          "type": "OTHER"
        },
        {
          "name": "Quick Board",
          "type": "OTHER"
        },
        {
          "name": "Advanced Medical Technologies Inc, Jump Test",
          "type": "OTHER"
        },
        {
          "name": "CGM/CKM",
          "type": "OTHER"
        },
        {
          "name": "Blood Draw",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Ketone Supplement",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL",
        "BIOLOGICAL",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 60,
      "start_date": "2023-06-20",
      "completion_date": "2026-09",
      "has_results": false,
      "last_update_posted_date": "2026-06-01",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05519644"
    },
    {
      "nct_id": "NCT00178035",
      "title": "Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Depression"
      ],
      "interventions": [
        {
          "name": "paroxetine",
          "type": "DRUG"
        },
        {
          "name": "One night of Total Sleep Deprivation",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 158,
      "start_date": "1999-12",
      "completion_date": "2003-08",
      "has_results": false,
      "last_update_posted_date": "2013-08-02",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00178035"
    },
    {
      "nct_id": "NCT02130791",
      "title": "Phenotypic and Genotypic Markers of Performance Vulnerability to Sleep Loss",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Restriction Then Total Sleep Deprivation",
        "Total Sleep Deprivation Then Sleep Restriction"
      ],
      "interventions": [
        {
          "name": "Sleep",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 170,
      "start_date": "2010-10",
      "completion_date": "2015-11",
      "has_results": false,
      "last_update_posted_date": "2015-12-02",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02130791"
    },
    {
      "nct_id": "NCT02836041",
      "title": "Sleep in Hospitalized Children at MSKCC",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pediatric Cancer Patients"
      ],
      "interventions": [
        {
          "name": "questionnaires",
          "type": "BEHAVIORAL"
        },
        {
          "name": "actigraph",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "Memorial Sloan Kettering Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Months",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "0 Months to 18 Years"
      },
      "enrollment_count": 66,
      "start_date": "2016-07-07",
      "completion_date": "2021-05-26",
      "has_results": false,
      "last_update_posted_date": "2021-05-28",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02836041"
    },
    {
      "nct_id": "NCT00581009",
      "title": "The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Bipolar Disorder"
      ],
      "interventions": [
        {
          "name": "chronobiological augmentation",
          "type": "OTHER"
        },
        {
          "name": "sertraline, lithium",
          "type": "DRUG"
        },
        {
          "name": "one night of sleep deprivation and two FDG PET scans",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG",
        "RADIATION"
      ],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 49,
      "start_date": "2001-05-30",
      "completion_date": "2011-12-09",
      "has_results": true,
      "last_update_posted_date": "2024-10-17",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 2,
      "location_summary": "Irvine, California • La Jolla, California",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        },
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00581009"
    },
    {
      "nct_id": "NCT03679962",
      "title": "Triple Chronotherapy in Adolescents",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depressive Disorder, Major",
        "Bipolar Depression",
        "Suicidal Ideation"
      ],
      "interventions": [
        {
          "name": "Triple Chronotherapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment as Usual",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Billings Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "12 Years to 17 Years"
      },
      "enrollment_count": 64,
      "start_date": "2019-01-25",
      "completion_date": "2023-03-14",
      "has_results": false,
      "last_update_posted_date": "2023-08-16",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "Billings, Montana",
      "locations": [
        {
          "city": "Billings",
          "state": "Montana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03679962"
    },
    {
      "nct_id": "NCT07346014",
      "title": "Sleep and Circadian Interventions for College Students at High Risk of Suicide",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Disturbance",
        "Sleep",
        "Depression",
        "Suicide"
      ],
      "interventions": [
        {
          "name": "Sleep Feedback + Psychoeducation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transdiagnostic Sleep and Circadian Intervention + Bright Light (TSC+)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Triple Chronotherapy (TCT+)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "18 Years to 25 Years"
      },
      "enrollment_count": 90,
      "start_date": "2026-06-18",
      "completion_date": "2029-03",
      "has_results": false,
      "last_update_posted_date": "2026-07-07",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07346014"
    },
    {
      "nct_id": "NCT02043977",
      "title": "Efficacy and Safety Study of Propofol Infusion for Refractory Chronic Primary Insomnia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Insomnia",
        "Sleep Disorder",
        "Dyssomnia"
      ],
      "interventions": [
        {
          "name": "propofol injectable emulsion",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Life Extension Foundation Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 2,
      "start_date": "2013-06",
      "completion_date": "2015-05",
      "has_results": false,
      "last_update_posted_date": "2016-08-30",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "Fort Lauderdale, Florida",
      "locations": [
        {
          "city": "Fort Lauderdale",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02043977"
    },
    {
      "nct_id": "NCT02945501",
      "title": "Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Deprivation",
        "Mental Competency"
      ],
      "interventions": [
        {
          "name": "NeuroConn DC Stimulator PLUS",
          "type": "DEVICE"
        },
        {
          "name": "SHAM TES",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "U.S. Army Medical Research and Development Command",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "39 Years",
        "sex": "ALL",
        "summary": "18 Years to 39 Years"
      },
      "enrollment_count": 40,
      "start_date": "2016-10-27",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2025-06-13",
      "last_synced_at": "2026-09-27T08:38:48.188Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02945501"
    }
  ]
}