{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Open-Chain+Leg+Exercise",
    "query": {
      "intervention": "Open-Chain Leg Exercise"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 8,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T09:12:19.062Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04782947",
      "title": "Epidural Stimulation and Resistance Training After SCI",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Spinal Cord Injuries"
      ],
      "interventions": [
        {
          "name": "Exoskeletal assisted walking",
          "type": "DEVICE"
        },
        {
          "name": "Epidural Stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Resistance Training",
          "type": "PROCEDURE"
        },
        {
          "name": "delayed-ES",
          "type": "DEVICE"
        },
        {
          "name": "no-Resistance training",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "United States Department of Defense",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 20,
      "start_date": "2021-02-03",
      "completion_date": "2026-05-31",
      "has_results": false,
      "last_update_posted_date": "2026-01-02",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04782947"
    },
    {
      "nct_id": "NCT06348836",
      "title": "The Effects of Open Chain Versus Closed Chain Strengthening on Dynamic Valgus During a Step Down Test",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dynamic Knee Valgus"
      ],
      "interventions": [
        {
          "name": "Exercise",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Alvernia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 10,
      "start_date": "2024-03-22",
      "completion_date": "2025-02-28",
      "has_results": false,
      "last_update_posted_date": "2024-04-05",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Reading, Pennsylvania",
      "locations": [
        {
          "city": "Reading",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06348836"
    },
    {
      "nct_id": "NCT02597673",
      "title": "Trial of Self-managed Approaches for Patellofemoral Pain Syndrome in Active Duty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Patellofemoral Pain Syndrome"
      ],
      "interventions": [
        {
          "name": "Home Exercise Program (HEP)",
          "type": "OTHER"
        },
        {
          "name": "NMES",
          "type": "DEVICE"
        },
        {
          "name": "TENS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "University of Tennessee",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 132,
      "start_date": "2015-07",
      "completion_date": "2018-05-31",
      "has_results": true,
      "last_update_posted_date": "2020-10-01",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Fort Campbell North, Kentucky",
      "locations": [
        {
          "city": "Fort Campbell North",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02597673"
    },
    {
      "nct_id": "NCT04086615",
      "title": "Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Patellofemoral Pain Syndrome"
      ],
      "interventions": [
        {
          "name": "NMES and exercise supplemented with high BFR",
          "type": "DEVICE"
        },
        {
          "name": "NMES and exercise supplemented with low BFR",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Tennessee",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "44 Years",
        "sex": "ALL",
        "summary": "18 Years to 44 Years"
      },
      "enrollment_count": 84,
      "start_date": "2020-08-04",
      "completion_date": "2022-03-31",
      "has_results": false,
      "last_update_posted_date": "2022-06-06",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Fort Campbell North, Kentucky",
      "locations": [
        {
          "city": "Fort Campbell North",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04086615"
    },
    {
      "nct_id": "NCT03135210",
      "title": "Leg Exercise During ECMO",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Refractory Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Open-Chain Leg Exercise",
          "type": "OTHER"
        },
        {
          "name": "Closed-Chain Leg Exercise",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 4,
      "start_date": "2017-11-13",
      "completion_date": "2020-02-01",
      "has_results": true,
      "last_update_posted_date": "2021-02-21",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03135210"
    },
    {
      "nct_id": "NCT06858293",
      "title": "Mental Imagery to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anterior Cruciate Ligament Reconstruction"
      ],
      "interventions": [
        {
          "name": "Mental Imagery Open Chain",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Mental Imagery Closed Chain",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Marquette University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2025-02-14",
      "completion_date": "2026-01-28",
      "has_results": false,
      "last_update_posted_date": "2025-03-10",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06858293"
    },
    {
      "nct_id": "NCT05008484",
      "title": "Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Spinal Cord Injury"
      ],
      "interventions": [
        {
          "name": "NMES",
          "type": "DEVICE"
        },
        {
          "name": "Vitamin D",
          "type": "DRUG"
        },
        {
          "name": "Passive movement",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 6,
      "start_date": "2021-10-01",
      "completion_date": "2024-06-13",
      "has_results": true,
      "last_update_posted_date": "2026-01-23",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05008484"
    },
    {
      "nct_id": "NCT02634814",
      "title": "The KNEEhabilitation Study: Improving Disability in Individuals With Knee Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Transcutaneous Electrical Nerve Stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Therapeutic Exercise",
          "type": "OTHER"
        },
        {
          "name": "Sham Transcutaneous Electrical Nerve Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "40 Years to 75 Years"
      },
      "enrollment_count": 90,
      "start_date": "2015-10",
      "completion_date": "2017-11-01",
      "has_results": true,
      "last_update_posted_date": "2019-03-06",
      "last_synced_at": "2026-09-03T09:12:19.062Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02634814"
    }
  ]
}