{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Optic+Nerve+Stimulation",
    "query": {
      "intervention": "Optic Nerve Stimulation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 18,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Optic+Nerve+Stimulation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-08T18:47:28.506Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00186888",
      "title": "Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Retinoblastoma",
        "Retinal Neoplasm"
      ],
      "interventions": [
        {
          "name": "Enucleation",
          "type": "PROCEDURE"
        },
        {
          "name": "Vincristine, Carboplatin",
          "type": "DRUG"
        },
        {
          "name": "Focal Therapies",
          "type": "PROCEDURE"
        },
        {
          "name": "External Beam Radiation",
          "type": "RADIATION"
        },
        {
          "name": "Vincristine and Topotecan",
          "type": "DRUG"
        },
        {
          "name": "Vincristine + Carboplatin + Etoposide",
          "type": "DRUG"
        },
        {
          "name": "vincristine, cyclophosphamide, and doxorubicin",
          "type": "DRUG"
        },
        {
          "name": "Vincristine, Carboplatin and Etoposide",
          "type": "DRUG"
        },
        {
          "name": "Periocular carboplatin",
          "type": "PROCEDURE"
        },
        {
          "name": "G-CSF",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG",
        "RADIATION",
        "OTHER"
      ],
      "sponsor": "St. Jude Children's Research Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 107,
      "start_date": "2005-04-07",
      "completion_date": "2024-11-12",
      "has_results": true,
      "last_update_posted_date": "2025-09-04",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00186888"
    },
    {
      "nct_id": "NCT01019343",
      "title": "Physiological Investigations of Movement Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson's Disease",
        "Tourette's Syndrome",
        "Tic Disorders",
        "Dystonia",
        "Movement Disorders"
      ],
      "interventions": [
        {
          "name": "Transcranial Direct Current Stimulation (tDCS)",
          "type": "PROCEDURE"
        },
        {
          "name": "Eye-tracking Device",
          "type": "DEVICE"
        },
        {
          "name": "Pulsed vibrator",
          "type": "DEVICE"
        },
        {
          "name": "Gait Trainer Treadmill (GTT)",
          "type": "OTHER"
        },
        {
          "name": "Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCA",
          "type": "OTHER"
        },
        {
          "name": "iMobility",
          "type": "DEVICE"
        },
        {
          "name": "QMAT",
          "type": "DEVICE"
        },
        {
          "name": "Treadmill Test",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Arm Intellistretch Device",
          "type": "DEVICE"
        },
        {
          "name": "Transcranial Sonography (TCS)",
          "type": "PROCEDURE"
        },
        {
          "name": "Behavioral tasks",
          "type": "OTHER"
        },
        {
          "name": "TMS single/paired pulse",
          "type": "PROCEDURE"
        },
        {
          "name": "MEG",
          "type": "PROCEDURE"
        },
        {
          "name": "EEG",
          "type": "PROCEDURE"
        },
        {
          "name": "MRI techniques",
          "type": "PROCEDURE"
        },
        {
          "name": "Peripheral Nerve Stimulation",
          "type": "PROCEDURE"
        },
        {
          "name": "EMG",
          "type": "PROCEDURE"
        },
        {
          "name": "Trancutaneous spinal direct current stimulation (tsDCS)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE",
        "OTHER",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1273,
      "start_date": "2009-12-08",
      "completion_date": "2020-10-09",
      "has_results": false,
      "last_update_posted_date": "2026-07-02",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01019343"
    },
    {
      "nct_id": "NCT07523113",
      "title": "ME/CFS Brain Fog: Cognitive Rehabilitation Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ME/CFS",
        "ME/CFS Following EBV-associated Infectious Mononucleosis",
        "ME/CFS Following COVID-19",
        "Chronic Fatigue",
        "Chronic Fatigue Syndrome (CFS)",
        "Brain Fog",
        "Cognitive Impairment",
        "Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Processing Speed Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "In-session Instrumental Activities of Daily Living Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transfer Package",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Follow Up Phone Calls",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Trans-auricular Vagus Nerve Stimulation: High Intensity",
          "type": "PROCEDURE"
        },
        {
          "name": "In-session Brain Health Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Reaction Time Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Trans-auricular Vagus Nerve Stimulation: Low Intensity",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "PROCEDURE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2026-06-23",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-08-14",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07523113"
    },
    {
      "nct_id": "NCT06095297",
      "title": "Long COVID Brain Fog: Cognitive Rehabilitation Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Long COVID",
        "Brain Fog",
        "Cognitive Impairment",
        "Cognitive Dysfunction",
        "Post-Acute COVID-19 Syndrome"
      ],
      "interventions": [
        {
          "name": "Processing Speed Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "In-lab Instrumental Activities of Daily Living Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "In-lab Brain Health Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transfer Package",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Follow Up Phone Calls",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Vocational Rehabilitation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Peer Mentoring",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Reaction Time Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Trans-auricular Vagus Nerve Stimulation: High Intensity",
          "type": "PROCEDURE"
        },
        {
          "name": "Trans-auricular Vagus Nerve Stimulation: Low Intensity",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "PROCEDURE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2024-04-25",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06095297"
    },
    {
      "nct_id": "NCT00575536",
      "title": "Optical Stimulation in Peripheral Nerves for Select Rhizotomy Procedures",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spasticity"
      ],
      "interventions": [
        {
          "name": "Rhizotomy for children with spasticity",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "3 Years to 17 Years"
      },
      "enrollment_count": 19,
      "start_date": "2006-01",
      "completion_date": "2017-11",
      "has_results": false,
      "last_update_posted_date": "2018-05-01",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00575536"
    },
    {
      "nct_id": "NCT03166046",
      "title": "Migraine Prevention Using ActiPatch",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Migraine"
      ],
      "interventions": [
        {
          "name": "Pulsed Shortwave Therapy",
          "type": "DEVICE"
        },
        {
          "name": "Placebo Pulsed Shortwave therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "BioElectronics Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 45,
      "start_date": "2017-06-01",
      "completion_date": "2018-04-30",
      "has_results": false,
      "last_update_posted_date": "2018-08-02",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03166046"
    },
    {
      "nct_id": "NCT06681779",
      "title": "A Study of Transcutaneous Electrical Stimulation As a Noxious Stimulus for the Glasgow Coma Scale",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Comatose"
      ],
      "interventions": [
        {
          "name": "Transcutaneous electrical stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Standard of Care (SOC)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Markey Olson",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 90,
      "start_date": "2024-10-31",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-11-08",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06681779"
    },
    {
      "nct_id": "NCT00748059",
      "title": "The Pathophysiology of Orthostatic Hypotension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Autonomic Nervous System Diseases",
        "Orthostatic Hypotension",
        "Dopamine Beta-Hydroxylase Deficiency",
        "Orthostatic Intolerance"
      ],
      "interventions": [
        {
          "name": "Standing or upright tilt",
          "type": "PROCEDURE"
        },
        {
          "name": "Microneurography",
          "type": "PROCEDURE"
        },
        {
          "name": "QSweat",
          "type": "PROCEDURE"
        },
        {
          "name": "neck cuff stimulation",
          "type": "DEVICE"
        },
        {
          "name": "phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine",
          "type": "DRUG"
        },
        {
          "name": "clonidine,yohimbine,metoclopramide,alpha-methyldopa",
          "type": "DRUG"
        },
        {
          "name": "BodPod",
          "type": "PROCEDURE"
        },
        {
          "name": "Eye exam",
          "type": "PROCEDURE"
        },
        {
          "name": "Sleep study",
          "type": "PROCEDURE"
        },
        {
          "name": "Pain response testing",
          "type": "PROCEDURE"
        },
        {
          "name": "Metabolic chamber",
          "type": "PROCEDURE"
        },
        {
          "name": "Brain function studies",
          "type": "PROCEDURE"
        },
        {
          "name": "Bicycle Exercise Test",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "12 Years to 70 Years"
      },
      "enrollment_count": 10,
      "start_date": "1996-12",
      "completion_date": "2020-12",
      "has_results": false,
      "last_update_posted_date": "2021-05-12",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00748059"
    },
    {
      "nct_id": "NCT05110183",
      "title": "Opto-electrical Cochlear Implants",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hearing Loss"
      ],
      "interventions": [
        {
          "name": "electrical stimulation",
          "type": "DEVICE"
        },
        {
          "name": "optical stimulation",
          "type": "OTHER"
        },
        {
          "name": "combined optical and electrical stimulation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 30,
      "start_date": "2025-04-20",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-06",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 2,
      "location_summary": "Coral Gables, Florida • Columbia, Missouri",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Columbia",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05110183"
    },
    {
      "nct_id": "NCT06788977",
      "title": "External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pregnancy",
        "Migraine",
        "Headache",
        "Postpartum",
        "Depression",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "external Trigeminal Nerve Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cefaly Technology",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "44 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 44 Years · Female only"
      },
      "enrollment_count": 550,
      "start_date": "2024-11-25",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-15",
      "last_synced_at": "2026-09-08T18:47:28.506Z",
      "location_count": 1,
      "location_summary": "Darien, Connecticut",
      "locations": [
        {
          "city": "Darien",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06788977"
    }
  ]
}