{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Optimal+Medical+treatment", "query": { "intervention": "Optimal Medical treatment" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 104, "total_pages": 11, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Optimal+Medical+treatment&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-16T14:10:21.355Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07754526", "title": "OCM™ Treatment With Routine Care in Venous Leg Ulcers Compared to Routine Care Treatment Alone.", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Venous Leg Ulcer (VLU)" ], "interventions": [ { "name": "Omeza OCM™ Wound Matrix", "type": "DEVICE" }, { "name": "Routine Care", "type": "PROCEDURE" } ], "intervention_types": [ "DEVICE", "PROCEDURE" ], "sponsor": "Omeza, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 254, "start_date": "2026-08", "completion_date": "2028-12", "has_results": false, "last_update_posted_date": "2026-08-10", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 1, "location_summary": "Lake Success, New York", "locations": [ { "city": "Lake Success", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT07754526" }, { "nct_id": "NCT04986670", "title": "NutriCare Plus a Medically Tailored Meal Intervention Among Patients With Lung Cancer", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lung Cancer, Small Cell", "Lung Cancer Metastatic", "Lung Cancer Recurrent", "Treatment Side Effects", "Lung Cancer, Non-small Cell", "Nutritional Imbalance" ], "interventions": [ { "name": "Nutritional Counseling", "type": "BEHAVIORAL" }, { "name": "Medically Tailored Meals (MTMs)", "type": "OTHER" }, { "name": "Nutrition Prescription", "type": "BEHAVIORAL" }, { "name": "Nutrition Assessment", "type": "OTHER" }, { "name": "Nutrition Toolkit", "type": "BEHAVIORAL" }, { "name": "Monthly Emails", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL", "OTHER" ], "sponsor": "Tufts University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 299, "start_date": "2020-11-24", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2025-09-30", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 4, "location_summary": "Boston, Massachusetts • Columbus, Ohio • Philadelphia, Pennsylvania + 1 more", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Columbus", "state": "Ohio" }, { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04986670" }, { "nct_id": "NCT05687110", "title": "Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Metastatic Malignant Solid Neoplasm", "Unresectable Malignant Solid Neoplasm" ], "interventions": [ { "name": "Biopsy Procedure", "type": "PROCEDURE" }, { "name": "Biospecimen Collection", "type": "PROCEDURE" }, { "name": "Diagnostic Imaging Testing", "type": "PROCEDURE" }, { "name": "Novobiocin Sodium", "type": "BIOLOGICAL" } ], "intervention_types": [ "PROCEDURE", "BIOLOGICAL" ], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 43, "start_date": "2023-07-06", "completion_date": "2028-07-01", "has_results": false, "last_update_posted_date": "2026-08-03", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 22, "location_summary": "Duarte, California • Irvine, California • La Jolla, California + 14 more", "locations": [ { "city": "Duarte", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05687110" }, { "nct_id": "NCT02052817", "title": "Randomized, Prospective Evaluation of the Toad Brace in Plantar Ulcer Off-loading and Healing", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Diabetic Foot", "Pedal Ulcers" ], "interventions": [ { "name": "Optimal Medical Therapy Debridement + Toad Brace", "type": "DEVICE" }, { "name": "Optimal Medical Therapy - Debridement", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Toad Medical Corporation", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 74, "start_date": "2013-12", "completion_date": null, "has_results": false, "last_update_posted_date": "2014-02-03", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT02052817" }, { "nct_id": "NCT01471522", "title": "International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cardiovascular Diseases", "Coronary Disease", "Coronary Artery Disease", "Heart Diseases", "Myocardial Ischemia" ], "interventions": [ { "name": "cardiac catheterization", "type": "PROCEDURE" }, { "name": "coronary artery bypass graft surgery", "type": "PROCEDURE" }, { "name": "percutaneous coronary intervention", "type": "PROCEDURE" }, { "name": "Lifestyle", "type": "BEHAVIORAL" }, { "name": "Medication", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "BEHAVIORAL", "DRUG" ], "sponsor": "NYU Langone Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 5179, "start_date": "2012-07", "completion_date": "2023-05-30", "has_results": true, "last_update_posted_date": "2023-06-01", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 109, "location_summary": "Birmingham, Alabama • Yuma, Arizona • Beverly Hills, California + 82 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Yuma", "state": "Arizona" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Fresno", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01471522" }, { "nct_id": "NCT01775436", "title": "Palliative Care in People Living With HIV/AIDS: Integrating Into Standard of Care", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "HIV" ], "interventions": [ { "name": "FAmily-CEntered Advance Care Planning", "type": "BEHAVIORAL" }, { "name": "Healthy Living Control", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Children's National Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 444, "start_date": "2013-10-13", "completion_date": "2017-03-28", "has_results": false, "last_update_posted_date": "2020-07-15", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 5, "location_summary": "Washington D.C., District of Columbia", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01775436" }, { "nct_id": "NCT05734690", "title": "COPILOT-HF: Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Heart Failure" ], "interventions": [ { "name": "SGLT2i, beta blocker, ARNI, MRA, MTD", "type": "DRUG" }, { "name": "Education-First", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 503, "start_date": "2023-05-05", "completion_date": "2025-06-09", "has_results": false, "last_update_posted_date": "2026-02-06", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT05734690" }, { "nct_id": "NCT07454980", "title": "Pivotal Trial to Evaluate TraNsvenous TrIcuspid Valve ReplacemenT With LuX-Valve Plus System (The TRINITY Pivotal Trial)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Tricuspid Regurgitation (TR)" ], "interventions": [ { "name": "TTVI with LuX-Valve Plus System", "type": "DEVICE" }, { "name": "TTVI with EVOQUE", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Jenscare Innovation Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 680, "start_date": "2026-07-15", "completion_date": "2038-12", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 2, "location_summary": "Naples, Florida • The Bronx, New York", "locations": [ { "city": "Naples", "state": "Florida" }, { "city": "The Bronx", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT07454980" }, { "nct_id": "NCT03702244", "title": "The PRECISE Protocol: Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Coronary Artery Disease" ], "interventions": [ { "name": "cCTA with selective FFRct", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "HeartFlow, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2103, "start_date": "2018-11-27", "completion_date": "2022-05-20", "has_results": true, "last_update_posted_date": "2023-12-29", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 1, "location_summary": "Lake Charles, Louisiana", "locations": [ { "city": "Lake Charles", "state": "Louisiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT03702244" }, { "nct_id": "NCT03250247", "title": "Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Deep Vein Thrombosis", "Venous Stasis", "Venous Insufficiency", "Venous Leg Ulcer", "Venous Reflux", "Post Thrombotic Syndrome" ], "interventions": [ { "name": "Stents", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 225, "start_date": "2018-07-02", "completion_date": "2026-04-27", "has_results": false, "last_update_posted_date": "2026-01-28", "last_synced_at": "2026-09-16T14:10:21.355Z", "location_count": 29, "location_summary": "Orange, California • San Francisco, California • New Haven, Connecticut + 23 more", "locations": [ { "city": "Orange", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Newark", "state": "Delaware" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03250247" } ] }