{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Optional+Lumbar+puncture", "query": { "intervention": "Optional Lumbar puncture" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 13, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Optional+Lumbar+puncture&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-09T22:09:56.824Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02688985", "title": "Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Relapsing Multiple Sclerorsis", "Multiple Sclerosis, Primary Progressive" ], "interventions": [ { "name": "Ocrelizumab", "type": "DRUG" }, { "name": "Lumbar Puncture", "type": "PROCEDURE" }, { "name": "Methyloprednisolone", "type": "DRUG" }, { "name": "Antihistamine", "type": "DRUG" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Genentech, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 131, "start_date": "2016-04-29", "completion_date": "2023-04-11", "has_results": true, "last_update_posted_date": "2024-06-04", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 12, "location_summary": "Palo Alto, California • San Francisco, California • Aurora, Colorado + 9 more", "locations": [ { "city": "Palo Alto", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Worcester", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT02688985" }, { "nct_id": "NCT05212272", "title": "MRI in High-Grade Glioma Patients Undergoing Chemoradiation", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "High Grade Glioma" ], "interventions": [ { "name": "PET-MRI Brain Scan", "type": "PROCEDURE" }, { "name": "Blood draw", "type": "DIAGNOSTIC_TEST" }, { "name": "Memory testing", "type": "BEHAVIORAL" }, { "name": "Optional lumbar puncture for cerebrospinal fluid collection", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE", "DIAGNOSTIC_TEST", "BEHAVIORAL" ], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 16, "start_date": "2022-09-02", "completion_date": "2027-12", "has_results": false, "last_update_posted_date": "2026-08-17", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT05212272" }, { "nct_id": "NCT07110246", "title": "Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "BRAF V600 Mutation", "Low-grade Glioma", "Low Grade Glioma of Brain", "Recurrent Low Grade Glioma" ], "interventions": [ { "name": "Dabrafenib", "type": "DRUG" }, { "name": "Trametinib", "type": "DRUG" }, { "name": "Magnetic Resonance Imaging (MRI)", "type": "PROCEDURE" }, { "name": "Specimen Collection", "type": "PROCEDURE" }, { "name": "Optional Lumbar puncture", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Months", "maximum_age": "25 Years", "sex": "ALL", "summary": "12 Months to 25 Years" }, "enrollment_count": 96, "start_date": "2025-11-07", "completion_date": "2032-03-31", "has_results": false, "last_update_posted_date": "2026-09-03", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 10, "location_summary": "Birmingham, Alabama • San Francisco, California • Washington D.C., District of Columbia + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "San Francisco", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT07110246" }, { "nct_id": "NCT04708613", "title": "University of Pittsburgh Brain Health Initiative", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Traumatic Brain Injury" ], "interventions": [ { "name": "Cognitive/Neuropsychological Testing", "type": "DIAGNOSTIC_TEST" }, { "name": "Vestibular/Ocular-Motor Testing", "type": "DIAGNOSTIC_TEST" }, { "name": "Sleep Evaluation", "type": "DIAGNOSTIC_TEST" }, { "name": "MRI, High-Resolution", "type": "DIAGNOSTIC_TEST" }, { "name": "Health & Physical Exam", "type": "DIAGNOSTIC_TEST" }, { "name": "Physical Function", "type": "DIAGNOSTIC_TEST" }, { "name": "Blood Testing and Biomarker Analysis", "type": "DIAGNOSTIC_TEST" }, { "name": "Applanation Tonometry", "type": "DIAGNOSTIC_TEST" }, { "name": "PET brain imaging", "type": "DIAGNOSTIC_TEST" }, { "name": "[C-11]6-OH-BTA-1", "type": "DRUG" }, { "name": "[F-18]AV-1451", "type": "DRUG" } ], "intervention_types": [ "DIAGNOSTIC_TEST", "DRUG" ], "sponsor": "David Okonkwo, MD, PhD", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "29 Years", "maximum_age": "59 Years", "sex": "MALE", "summary": "29 Years to 59 Years · Male only" }, "enrollment_count": 300, "start_date": "2019-11-18", "completion_date": "2026-12", "has_results": false, "last_update_posted_date": "2026-06-22", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04708613" }, { "nct_id": "NCT02831283", "title": "Imaging Inflammation in Alzheimer's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "11C-PBR28", "type": "DRUG" }, { "name": "18F-Florbetaben", "type": "DRUG" }, { "name": "Lumbar puncture (optional)", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Patrick Lao", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 60, "start_date": "2016-06", "completion_date": "2022-12", "has_results": true, "last_update_posted_date": "2025-03-05", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02831283" }, { "nct_id": "NCT04515550", "title": "Mitochondrial Biomarkers in Huntington's Disease", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Huntington Disease" ], "interventions": [ { "name": "lumbar puncture", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "University Hospitals Cleveland Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "20 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "20 Years to 85 Years" }, "enrollment_count": 27, "start_date": "2019-04-04", "completion_date": "2022-02-28", "has_results": false, "last_update_posted_date": "2022-04-12", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04515550" }, { "nct_id": "NCT06176261", "title": "DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Breast Cancer", "Breast Cancer Female", "Metastatic Triple-Negative Breast Carcinoma", "ER Positive Breast Cancer", "HER2-negative Breast Cancer", "HER2 Negative Breast Carcinoma", "ER-negative Breast Cancer" ], "interventions": [ { "name": "Datopotamab Deruxtecan", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Nancy Lin, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 58, "start_date": "2024-01-08", "completion_date": "2029-01-01", "has_results": false, "last_update_posted_date": "2026-08-06", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 3, "location_summary": "Miami, Florida • Boston, Massachusetts • Durham, North Carolina", "locations": [ { "city": "Miami", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT06176261" }, { "nct_id": "NCT02884492", "title": "Imaging Tau in Alzheimer's Disease and Normal Aging", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "18F-THK-5351", "type": "DRUG" }, { "name": "Lumbar Puncture (optional)", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "William Charles Kreisl", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 17, "start_date": "2016-07", "completion_date": "2017-06-30", "has_results": true, "last_update_posted_date": "2018-11-19", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02884492" }, { "nct_id": "NCT02330965", "title": "Mechanistic Studies of Phase III Trial With BAF312 in Secondary Progressive Multiple Sclerosis", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Secondary Progressive Multiple Sclerosis" ], "interventions": [ { "name": "Blood Draw", "type": "PROCEDURE" }, { "name": "CSF collection by lumbar puncture (Optional)", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 36, "start_date": "2014-12", "completion_date": "2017-07-12", "has_results": false, "last_update_posted_date": "2020-11-09", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 13, "location_summary": "Berkeley, California • Los Angeles, California • Sacramento, California + 10 more", "locations": [ { "city": "Berkeley", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT02330965" }, { "nct_id": "NCT05430490", "title": "Cannabis, HIV and Mental Processing Systems", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "HIV Infections", "Cannabis" ], "interventions": [ { "name": "MRI", "type": "PROCEDURE" }, { "name": "NeuroPsychological Testing", "type": "OTHER" }, { "name": "Blood Draw", "type": "PROCEDURE" }, { "name": "Questionnaires", "type": "OTHER" }, { "name": "Lumbar Puncture", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE", "OTHER" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 276, "start_date": "2022-03-23", "completion_date": "2026-03-01", "has_results": false, "last_update_posted_date": "2026-04-07", "last_synced_at": "2026-09-09T22:09:56.824Z", "location_count": 2, "location_summary": "St Louis, Missouri • Newark, New Jersey", "locations": [ { "city": "St Louis", "state": "Missouri" }, { "city": "Newark", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05430490" } ] }