{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Oxygen+-+hyperoxia&page=2",
    "query": {
      "intervention": "Oxygen - hyperoxia",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Oxygen+-+hyperoxia&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-25T18:43:45.925Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03268590",
      "title": "Neuroimaging During Pure Oxygen Breathing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Hyperoxia",
        "Hypoxia, Brain",
        "Neurobehavioral Manifestations"
      ],
      "interventions": [
        {
          "name": "Oxygen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 33,
      "start_date": "2017-10-02",
      "completion_date": "2018-05-09",
      "has_results": true,
      "last_update_posted_date": "2019-11-13",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03268590"
    },
    {
      "nct_id": "NCT02509182",
      "title": "The Effect of Decreasing the Inspired Oxygen Concentration on Post-Operative Oxygenation After Primary Lobectomy",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Hyperoxia"
      ],
      "interventions": [
        {
          "name": "60% oxygen",
          "type": "DRUG"
        },
        {
          "name": "100% oxygen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2016-12",
      "completion_date": "2018-07",
      "has_results": false,
      "last_update_posted_date": "2018-01-12",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02509182"
    },
    {
      "nct_id": "NCT06374225",
      "title": "Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Illness",
        "Wounds and Injury",
        "Disease Attributes",
        "Pathologic Processes"
      ],
      "interventions": [
        {
          "name": "Automated Titration (O2matic)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2024-04-29",
      "completion_date": "2026-01-09",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 4,
      "location_summary": "Aurora, Colorado • Winston-Salem, North Carolina • Portland, Oregon + 1 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06374225"
    },
    {
      "nct_id": "NCT01881243",
      "title": "Reoxygenation After Cardiac Arrest (REOX Study)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiac Arrest"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "The Cooper Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 280,
      "start_date": "2013-06",
      "completion_date": "2017-06",
      "has_results": false,
      "last_update_posted_date": "2019-11-25",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 5,
      "location_summary": "Indianapolis, Indiana • Boston, Massachusetts • Jackson, Mississippi + 2 more",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Jackson",
          "state": "Mississippi"
        },
        {
          "city": "Camden",
          "state": "New Jersey"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01881243"
    },
    {
      "nct_id": "NCT02473354",
      "title": "Predictors of Opioid-Induced Respiratory Depression (OIRD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Respiratory Depression"
      ],
      "interventions": [
        {
          "name": "Remifentanil",
          "type": "DRUG"
        },
        {
          "name": "Oxygen",
          "type": "DRUG"
        },
        {
          "name": "Carbon dioxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 30,
      "start_date": "2015-04",
      "completion_date": "2018-04-29",
      "has_results": false,
      "last_update_posted_date": "2020-03-10",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02473354"
    },
    {
      "nct_id": "NCT04540276",
      "title": "Intraoperative Hyperoxia and MINS",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hyperoxia",
        "Myocardial Infarction",
        "Myocardial Injury"
      ],
      "interventions": [
        {
          "name": "Inspiratory oxygen fraction",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University Hospital Bispebjerg and Frederiksberg",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 7700,
      "start_date": "2018-02-04",
      "completion_date": "2021-03-01",
      "has_results": false,
      "last_update_posted_date": "2021-02-04",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04540276"
    },
    {
      "nct_id": "NCT02407028",
      "title": "Hyperbaric Oxygen Brain Injury Treatment Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Hyperbaric oxygen (1.5 ATA, no NBH)",
          "type": "DRUG"
        },
        {
          "name": "Hyperbaric oxygen (2.0 ATA, no NBH)",
          "type": "DRUG"
        },
        {
          "name": "Hyperbaric oxygen (2.5 ATA, no NBH)",
          "type": "DRUG"
        },
        {
          "name": "Hyperbaric oxygen (1.5 ATA + NBH)",
          "type": "DRUG"
        },
        {
          "name": "Hyperbaric oxygen (2.0 ATA + NBH)",
          "type": "DRUG"
        },
        {
          "name": "Hyperbaric oxygen (2.5 ATA + NBH)",
          "type": "DRUG"
        },
        {
          "name": "Normobaric Hyperoxia (NBH)",
          "type": "DRUG"
        },
        {
          "name": "Usual Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Gaylan Rockswold",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "16 Years to 65 Years"
      },
      "enrollment_count": 200,
      "start_date": "2018-06-25",
      "completion_date": "2029-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-06-02",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 10,
      "location_summary": "San Diego, California • West Palm Beach, Florida • Iowa City, Iowa + 7 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "West Palm Beach",
          "state": "Florida"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02407028"
    },
    {
      "nct_id": "NCT05767385",
      "title": "Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Congenital Heart Disease in Children",
        "Hypoxia",
        "Neurodevelopmental Disorders",
        "Complex Congenital Heart Disease"
      ],
      "interventions": [
        {
          "name": "Single Arm",
          "type": "PROCEDURE"
        },
        {
          "name": "Neonatal Neurobehavioral Scale",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Years",
        "maximum_age": "52 Years",
        "sex": "FEMALE",
        "summary": "0 Years to 52 Years · Female only"
      },
      "enrollment_count": 104,
      "start_date": "2021-12-17",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-14",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 5,
      "location_summary": "San Francisco, California • Washington D.C., District of Columbia • Scarborough, Maine + 1 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Scarborough",
          "state": "Maine"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05767385"
    },
    {
      "nct_id": "NCT05344274",
      "title": "Retinal Blood Flow and Autoregulation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Glaucoma"
      ],
      "interventions": [
        {
          "name": "Indocyanine Green Angiography",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Isocapnic Oxygen",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO)",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "BIOLOGICAL"
      ],
      "sponsor": "University of Maryland, Baltimore",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "88 Years",
        "sex": "ALL",
        "summary": "18 Years to 88 Years"
      },
      "enrollment_count": 90,
      "start_date": "2022-05-23",
      "completion_date": "2027-09",
      "has_results": false,
      "last_update_posted_date": "2025-12-02",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 4,
      "location_summary": "Baltimore, Maryland • Silver Spring, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Silver Spring",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05344274"
    },
    {
      "nct_id": "NCT05589753",
      "title": "Sleep Disordered Breathing With Opioid Use",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Sleep Apnea",
        "Opioid Use",
        "Sleep Disordered Breathing"
      ],
      "interventions": [
        {
          "name": "Hyperoxia",
          "type": "OTHER"
        },
        {
          "name": "Acetazolamide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 150,
      "start_date": "2019-05-02",
      "completion_date": "2027-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-01",
      "last_synced_at": "2026-09-25T18:43:45.925Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05589753"
    }
  ]
}