{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Oxymetazoline+0.05%25", "query": { "intervention": "Oxymetazoline 0.05%" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 20, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Oxymetazoline+0.05%25&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-30T06:17:18.090Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01479517", "title": "Open-Label Study of Efficacy and Recommended Dose of Kovacaine Mist for Anesthetizing Maxillary Teeth", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "Kovacaine Mist 0.1 mL x 4 sprays", "type": "DRUG" }, { "name": "Kovacaine Mist 0.2 mL x 2 sprays", "type": "DRUG" }, { "name": "Kovacaine Mist 0.2 mL x 1 spray", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Renatus, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2012-01", "completion_date": "2012-04", "has_results": true, "last_update_posted_date": "2016-12-29", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 1, "location_summary": "Colorado Springs, Colorado", "locations": [ { "city": "Colorado Springs", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01479517" }, { "nct_id": "NCT01844830", "title": "Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Pediatric Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "Tetracaine HCl 3% and Oxymetazoline HCl 0.05%", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Renatus, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "3 Years to 17 Years" }, "enrollment_count": 90, "start_date": "2013-05", "completion_date": "2013-07", "has_results": true, "last_update_posted_date": "2017-08-30", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 2, "location_summary": "Loma Linda, California • Fort Collins, Colorado", "locations": [ { "city": "Loma Linda", "state": "California" }, { "city": "Fort Collins", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01844830" }, { "nct_id": "NCT01925729", "title": "TransMEM Gas Exchange -- Project 1, Aim 2", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Middle Ear Disease", "Nasal Allergy" ], "interventions": [ { "name": "ragweed", "type": "BIOLOGICAL" }, { "name": "histamine", "type": "BIOLOGICAL" }, { "name": "pseudoephedrine", "type": "DRUG" }, { "name": "Oxymetazoline", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Cuneyt M. Alper", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 84, "start_date": "2013-10-01", "completion_date": "2019-03-22", "has_results": false, "last_update_posted_date": "2020-02-07", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01925729" }, { "nct_id": "NCT01745380", "title": "Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "Tetracaine HCl 3% and Oxymetazoline HCl 0.05%", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Renatus, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 150, "start_date": "2013-02", "completion_date": "2013-05", "has_results": true, "last_update_posted_date": "2017-01-31", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 3, "location_summary": "Loma Linda, California • Baltimore, Maryland • Philadelphia, Pennsylvania", "locations": [ { "city": "Loma Linda", "state": "California" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01745380" }, { "nct_id": "NCT01701505", "title": "Dose-Ranging Study of Intranasal Kovacaine Mist in Pediatric Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "400uL of Kovacaine Mist", "type": "DRUG" }, { "name": "200uL of Kovacaine Mist", "type": "DRUG" }, { "name": "120uL of Kovacaine Mist", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Renatus, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "3 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "3 Years to 17 Years" }, "enrollment_count": 48, "start_date": "2012-10", "completion_date": "2012-10", "has_results": true, "last_update_posted_date": "2017-08-30", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 1, "location_summary": "Fort Collins, Colorado", "locations": [ { "city": "Fort Collins", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01701505" }, { "nct_id": "NCT01660893", "title": "Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "Tetracaine HCl 3% and oxymetazoline HCl 0.05%", "type": "DRUG" }, { "name": "Tetracaine HCl 3%", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Renatus, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 26, "start_date": "2012-08", "completion_date": "2012-09", "has_results": true, "last_update_posted_date": "2017-09-05", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 3, "location_summary": "Baltimore, Maryland • Salt Lake City, Utah", "locations": [ { "city": "Baltimore", "state": "Maryland" }, { "city": "Salt Lake City", "state": "Utah" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT01660893" }, { "nct_id": "NCT02457806", "title": "Comparison of Anesthetic Efficacy of Bilateral and Unillateral Application of Kovacaine Mist in Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "Tetracaine HCl 3% and Oxymetazoline HCl 0.05%", "type": "DRUG" }, { "name": "Placebo spray", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Renatus, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 48, "start_date": "2011-08", "completion_date": "2011-10", "has_results": false, "last_update_posted_date": "2016-11-10", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT02457806" }, { "nct_id": "NCT03228914", "title": "Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Endoscopic Sinus Surgery", "Nasal Polyps" ], "interventions": [ { "name": "Oxymetazoline", "type": "DRUG" }, { "name": "Epinephrine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2018-06-14", "completion_date": "2018-08-29", "has_results": true, "last_update_posted_date": "2021-01-13", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03228914" }, { "nct_id": "NCT01304316", "title": "Dose-Escalation Safety and Pharmacokinetic Study of K305", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "Tetracaine HCl 3% and Oxymetazoline HCl 0.05%", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Renatus, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 12, "start_date": "2010-09", "completion_date": "2010-11", "has_results": true, "last_update_posted_date": "2017-08-31", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01304316" }, { "nct_id": "NCT00223691", "title": "Treatment of Orthostatic Hypotension in Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Autonomic Failure", "Orthostatic Hypotension" ], "interventions": [ { "name": "Atomoxetine", "type": "DRUG" }, { "name": "Acarbose", "type": "DRUG" }, { "name": "Pyridostigmine Bromide", "type": "DRUG" }, { "name": "Yohimbine", "type": "DRUG" }, { "name": "Midodrine HCl", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" }, { "name": "Modafinil", "type": "DRUG" }, { "name": "Octreotide", "type": "DRUG" }, { "name": "water intake", "type": "OTHER" }, { "name": "Diphenhydramine Hydrochloride", "type": "DRUG" }, { "name": "Ranitidine HCL", "type": "DRUG" }, { "name": "Tranylcypromine", "type": "DRUG" }, { "name": "Ergotamine/ Caffeine", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Pseudoephedrine", "type": "DRUG" }, { "name": "Methylphenidate", "type": "DRUG" }, { "name": "Indomethacin", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Oxymetazoline 0.05% nasal solution", "type": "DRUG" }, { "name": "Bovril", "type": "DIETARY_SUPPLEMENT" }, { "name": "Acetazolamide", "type": "DRUG" }, { "name": "Rivastigmine tartrate", "type": "DRUG" }, { "name": "Carbidopa/levodopa", "type": "DRUG" }, { "name": "Inflatable abdominal binder", "type": "DEVICE" }, { "name": "inflatable abdominal binder (sham)", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "OTHER", "DIETARY_SUPPLEMENT", "DEVICE" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 389, "start_date": "2002-03", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2017-01-18", "last_synced_at": "2026-09-30T06:17:18.090Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00223691" } ] }