{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Paroxetine%2C+Sertraline%2C+Citalopram+or+Fluoxetine.", "query": { "intervention": "Paroxetine, Sertraline, Citalopram or Fluoxetine." }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 15, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Paroxetine%2C+Sertraline%2C+Citalopram+or+Fluoxetine.&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-09T20:26:11.573Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00612807", "title": "Treatment of Mood and Marriage Study (TOMMS)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Major Depressive Disorder", "Partner Relational Disorder (V61.10)" ], "interventions": [ { "name": "Weekly marital therapy", "type": "BEHAVIORAL" }, { "name": "As indicated: Sertraline, bupropion, venlafaxine, mirtazepine, nortriptyline, tranylcypromine, lithium augmentation, etc.", "type": "DRUG" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 42, "start_date": "2006-07", "completion_date": "2010-06", "has_results": true, "last_update_posted_date": "2013-06-24", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00612807" }, { "nct_id": "NCT03321526", "title": "A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "JNJ-42847922", "type": "DRUG" }, { "name": "Placebo Matching to JNJ-42847922", "type": "DRUG" }, { "name": "Quetiapine XR", "type": "DRUG" }, { "name": "Placebo Matching to Quetiapine XR", "type": "DRUG" }, { "name": "Selective Serotonin Reuptake Inhibitor (SSRI)", "type": "DRUG" }, { "name": "Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 107, "start_date": "2017-12-12", "completion_date": "2019-06-27", "has_results": true, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 50, "location_summary": "Phoenix, Arizona • Tempe, Arizona • Rogers, Arkansas + 41 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Garden Grove", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03321526" }, { "nct_id": "NCT01838681", "title": "Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Brexpiprazole", "type": "DRUG" }, { "name": "ADT", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "H. Lundbeck A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 1986, "start_date": "2013-06", "completion_date": "2016-06", "has_results": true, "last_update_posted_date": "2017-08-09", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 8, "location_summary": "Little Rock, Arkansas • Cerritos, California • Temecula, California + 4 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Cerritos", "state": "California" }, { "city": "Temecula", "state": "California" }, { "city": "Flowood", "state": "Mississippi" }, { "city": "Brooklyn", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01838681" }, { "nct_id": "NCT01838876", "title": "Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Cariprazine", "type": "DRUG" }, { "name": "Antidepressant Therapy (ADT)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 442, "start_date": "2013-04-29", "completion_date": "2015-07-27", "has_results": true, "last_update_posted_date": "2019-08-21", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 88, "location_summary": "Tucson, Arizona • Fayetteville, Arkansas • Little Rock, Arkansas + 74 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Fayetteville", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01838876" }, { "nct_id": "NCT01360866", "title": "Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder", "Depression", "Depressive Disorder, Major", "Mood Disorders", "Mental Disorders" ], "interventions": [ { "name": "OPC-34712", "type": "DRUG" }, { "name": "Escitalopram", "type": "DRUG" }, { "name": "Fluoxetine", "type": "DRUG" }, { "name": "Paroxetine CR", "type": "DRUG" }, { "name": "Sertraline", "type": "DRUG" }, { "name": "Duloxetine", "type": "DRUG" }, { "name": "Venlafaxine XR", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 2944, "start_date": "2011-10", "completion_date": "2017-05-18", "has_results": true, "last_update_posted_date": "2018-09-17", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 93, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 90 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Costa Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01360866" }, { "nct_id": "NCT00074815", "title": "Treatment of Obsessive Compulsive Disorder in Children", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obsessive-Compulsive Disorder" ], "interventions": [ { "name": "Serotonin reuptake inhibitors management", "type": "DRUG" }, { "name": "Cognitive behavioral therapy by a psychologist", "type": "BEHAVIORAL" }, { "name": "Instructional cognitive behavioral therapy by a psychiatrist", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "7 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "7 Years to 17 Years" }, "enrollment_count": 124, "start_date": "2003-09", "completion_date": "2009-11", "has_results": true, "last_update_posted_date": "2014-07-29", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 3, "location_summary": "Durham, North Carolina • Philadelphia, Pennsylvania • Providence, Rhode Island", "locations": [ { "city": "Durham", "state": "North Carolina" }, { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Providence", "state": "Rhode Island" } ], "official_url": "https://clinicaltrials.gov/study/NCT00074815" }, { "nct_id": "NCT02058693", "title": "Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "mixed salts amphetamine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Rush University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 41, "start_date": "2010-12", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2023-06-15", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02058693" }, { "nct_id": "NCT01254305", "title": "Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Levomilnacipran ER", "type": "DRUG" }, { "name": "Paroxetine, Sertraline, Citalopram or Fluoxetine.", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 262, "start_date": "2011-04", "completion_date": "2012-07", "has_results": true, "last_update_posted_date": "2014-08-06", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 20, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Cerritos, California + 17 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Cerritos", "state": "California" }, { "city": "Fort Myers", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01254305" }, { "nct_id": "NCT04437485", "title": "eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Depression", "Major Depressive Disorder", "Dysthymic Disorder", "Depressive Symptoms", "Type 2 Diabetes", "PreDiabetes", "Insulin Resistance" ], "interventions": [ { "name": "Good Days Ahead (GDA)", "type": "BEHAVIORAL" }, { "name": "Problem Solving Treatment in Primary Care (PST-PC)", "type": "BEHAVIORAL" }, { "name": "Antidepressant Medications", "type": "DRUG" }, { "name": "Active Control", "type": "OTHER" } ], "intervention_types": [ "BEHAVIORAL", "DRUG", "OTHER" ], "sponsor": "Indiana University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 46, "start_date": "2020-10-14", "completion_date": "2022-08-29", "has_results": true, "last_update_posted_date": "2023-11-02", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04437485" }, { "nct_id": "NCT04748276", "title": "Tracking Response to Antidepressants in Advance of Investigational Trials", "overall_status": "UNKNOWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "FDA-approved selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Adams Clinical", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 400, "start_date": "2019-01-02", "completion_date": "2023-12-31", "has_results": false, "last_update_posted_date": "2023-03-27", "last_synced_at": "2026-10-09T20:26:11.573Z", "location_count": 1, "location_summary": "Watertown, Massachusetts", "locations": [ { "city": "Watertown", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04748276" } ] }