{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=PfSPZ", "query": { "intervention": "PfSPZ" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 15, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=PfSPZ&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-05T12:42:18.432Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03083847", "title": "Dose Escalation PfSPZ-CVac", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "Chloroquine Phosphate", "type": "DRUG" }, { "name": "Pyrimethamine", "type": "DRUG" }, { "name": "Sanaria PfSPZ Challenge", "type": "BIOLOGICAL" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 55, "start_date": "2017-06-05", "completion_date": "2019-06-26", "has_results": true, "last_update_posted_date": "2021-06-01", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT03083847" }, { "nct_id": "NCT02601716", "title": "PfSPZ Vaccine: Dose Optimization With Heterologous Challenge in Healthy Malaria-Naïve Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" }, { "name": "CHMI (7G8)", "type": "BIOLOGICAL" }, { "name": "CHMI (NF135.C10)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Sanaria Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 92, "start_date": "2016-01", "completion_date": "2017-11", "has_results": false, "last_update_posted_date": "2018-10-16", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 2, "location_summary": "Baltimore, Maryland • Silver Spring, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" }, { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02601716" }, { "nct_id": "NCT07558122", "title": "Malaria CVD 36000; Gates INV090205", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria (Plasmodium Falciparum)" ], "interventions": [ { "name": "PfSPZ Challenge (NF54)", "type": "BIOLOGICAL" }, { "name": "Wearable Biosensor Devices", "type": "DEVICE" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "DEVICE", "OTHER" ], "sponsor": "University of Maryland, Baltimore", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 32, "start_date": "2026-06-13", "completion_date": "2026-08", "has_results": false, "last_update_posted_date": "2026-04-30", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT07558122" }, { "nct_id": "NCT02015091", "title": "Study of Controlled Human Malaria Infections to Evaluate Protection After Intravenous or Intramuscular Administration of PfSPZ Vaccine in Malaria-Naive Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 141, "start_date": "2013-12-12", "completion_date": "2016-09-08", "has_results": false, "last_update_posted_date": "2019-12-17", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 2, "location_summary": "Baltimore, Maryland • Bethesda, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" }, { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02015091" }, { "nct_id": "NCT01441167", "title": "Experimental PfSPZ Vaccine in Adults Without Malaria", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria", "Prevention and Control", "Acquired Immunity" ], "interventions": [ { "name": "PfSPZ", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 64, "start_date": "2011-09-14", "completion_date": "2013-06-05", "has_results": false, "last_update_posted_date": "2018-07-05", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01441167" }, { "nct_id": "NCT02562872", "title": "DSM265 Prophylaxis of Plasmodium Falciparum Malaria", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "DSM265", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Sporozoites", "type": "BIOLOGICAL" }, { "name": "Infective mosquito bite", "type": "BIOLOGICAL" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "Medicines for Malaria Venture", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 24, "start_date": "2016-03", "completion_date": "2017-05", "has_results": false, "last_update_posted_date": "2022-01-14", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT02562872" }, { "nct_id": "NCT05604521", "title": "A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria", "Malaria,Falciparum" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" }, { "name": "PfSPZ Challenge (7G8)", "type": "BIOLOGICAL" }, { "name": "Normal Saline", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "Sanaria Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 31, "start_date": "2022-12-06", "completion_date": "2023-09-05", "has_results": true, "last_update_posted_date": "2024-11-25", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT05604521" }, { "nct_id": "NCT02215707", "title": "A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Naïve Adults: Heterologous vs. Homologous Controlled Human Malaria Infection and Reduction in Number of Doses", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Sanaria Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 67, "start_date": "2014-06", "completion_date": "2015-06", "has_results": false, "last_update_posted_date": "2018-06-29", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02215707" }, { "nct_id": "NCT02780154", "title": "PfSPZ Challenge in Non-immune Adults in Baltimore, USA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Plasmodium Falciparum Infection" ], "interventions": [ { "name": "PfSPZ (7G8) Challenge", "type": "BIOLOGICAL" }, { "name": "PfSPZ (NF54) Challenge", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 30, "start_date": "2016-08-25", "completion_date": "2016-12-15", "has_results": false, "last_update_posted_date": "2019-01-28", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02780154" }, { "nct_id": "NCT06735209", "title": "First-in-Human PfSPZ-LARC2 Vaccination/CHMI", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" }, { "name": "PfSPZ (7G8) Challenge", "type": "BIOLOGICAL" }, { "name": "Sodium Chloride, 0.9%", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 22, "start_date": "2025-07-23", "completion_date": "2026-07-10", "has_results": false, "last_update_posted_date": "2026-08-17", "last_synced_at": "2026-09-05T12:42:18.432Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT06735209" } ] }