{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pharmacodynamics&page=18", "query": { "intervention": "Pharmacodynamics", "page": 18 }, "page_size": 10 }, "pagination": { "page": 18, "page_size": 10, "total_count": 3444, "total_pages": 345, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pharmacodynamics&page=19&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pharmacodynamics&page=17&page_size=10" }, "source": "remote", "last_synced_at": "2026-11-15T16:56:24.795Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03221400", "title": "PEN-866 in Patients With Advanced Solid Malignancies", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Carcinoma", "Endometrial Adenocarcinoma", "Neoplasms", "Squamous Cell Carcinoma of the Anus", "Adenocarcinoma of the Pancreas", "Advanced Cancer", "Solid Tumor", "Solid Carcinoma", "Squamous Cell Carcinoma of the Cervix", "Squamous Cell Carcinoma", "Squamous Cell Carcinoma of the Vulva", "Squamous Cell Carcinoma of the Penis", "Gastric Cancer", "Gastric Adenocarcinoma", "Gastroesophageal Junction Adenocarcinoma", "Small-cell Lung Cancer", "Small Cell Lung Carcinoma", "Pancreatic Ductal Adenocarcinoma", "Pancreatic Adenocarcinoma" ], "interventions": [ { "name": "PEN-866 Sodium", "type": "DRUG" }, { "name": "fluorouracil", "type": "DRUG" }, { "name": "Folinic acid", "type": "DRUG" }, { "name": "Niraparib", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tarveda Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 340, "start_date": "2017-08-29", "completion_date": "2023-06", "has_results": false, "last_update_posted_date": "2022-02-17", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 16, "location_summary": "Springdale, Arkansas • Denver, Colorado • Fort Myers, Florida + 13 more", "locations": [ { "city": "Springdale", "state": "Arkansas" }, { "city": "Denver", "state": "Colorado" }, { "city": "Fort Myers", "state": "Florida" }, { "city": "St. Petersburg", "state": "Florida" }, { "city": "West Palm Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03221400" }, { "nct_id": "NCT02493751", "title": "A Study Of Avelumab In Combination With Axitinib In Advanced Renal Cell Cancer (JAVELIN Renal 100)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Renal Cell Cancer" ], "interventions": [ { "name": "Avelumab (MSB0010718C)", "type": "DRUG" }, { "name": "Axitinib (AG-013736)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 55, "start_date": "2015-10-26", "completion_date": "2021-03-04", "has_results": true, "last_update_posted_date": "2022-02-18", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 12, "location_summary": "Scottsdale, Arizona • Washington D.C., District of Columbia • Boston, Massachusetts + 4 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT02493751" }, { "nct_id": "NCT01444872", "title": "Study to Evaluate TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Renal Dysfunction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Heart Failure", "Kidney Disease" ], "interventions": [ { "name": "TRV120027", "type": "DRUG" }, { "name": "Normal Saline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Trevena Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "74 Years", "sex": "ALL", "summary": "18 Years to 74 Years" }, "enrollment_count": 17, "start_date": "2011-08", "completion_date": "2012-06", "has_results": false, "last_update_posted_date": "2012-08-27", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 4, "location_summary": "Orlando, Florida • Minneapolis, Minnesota • Durham, North Carolina + 1 more", "locations": [ { "city": "Orlando", "state": "Florida" }, { "city": "Minneapolis", "state": "Minnesota" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Knoxville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT01444872" }, { "nct_id": "NCT06995651", "title": "Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Pancreatic Insufficiency", "Cystic Fibrosis-related Diabetes" ], "interventions": [ { "name": "Dorzagliatin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Michael R. Rickels, MD, MS", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 15, "start_date": "2025-10-21", "completion_date": "2027-07", "has_results": false, "last_update_posted_date": "2026-08-31", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 2, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT06995651" }, { "nct_id": "NCT00526838", "title": "Study of XL228 Administered Intravenously to Subjects With Advanced Malignancies", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Cancer", "Lymphoma" ], "interventions": [ { "name": "XL228", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Exelixis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 84, "start_date": "2007-09", "completion_date": "2010-12", "has_results": false, "last_update_posted_date": "2015-08-21", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 4, "location_summary": "Los Angeles, California • Atlanta, Georgia • Ann Arbor, Michigan + 1 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Ann Arbor", "state": "Michigan" }, { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00526838" }, { "nct_id": "NCT01787578", "title": "Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD)", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "X-Linked Adrenoleukodystrophy", "Adrenomyeloneuropathy" ], "interventions": [ { "name": "Sobetirome", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Thomas S. Scanlan", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "MALE", "summary": "18 Years to 64 Years · Male only" }, "enrollment_count": 0, "start_date": "2013-04", "completion_date": "2014-02", "has_results": false, "last_update_posted_date": "2014-02-14", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 1, "location_summary": "Portland, Oregon", "locations": [ { "city": "Portland", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT01787578" }, { "nct_id": "NCT02923115", "title": "Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Pulmonary Embolism", "Thrombotic Disease" ], "interventions": [ { "name": "DS-1040b", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Enoxaparin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Daiichi Sankyo", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 134, "start_date": "2016-06-23", "completion_date": "2019-08-05", "has_results": true, "last_update_posted_date": "2023-04-19", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 15, "location_summary": "Mobile, Alabama • Beverly Hills, California • San Diego, California + 12 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Beverly Hills", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Sarasota", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02923115" }, { "nct_id": "NCT04363736", "title": "A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "COVID-19 Pneumonia" ], "interventions": [ { "name": "Tociliuzumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 97, "start_date": "2020-05-05", "completion_date": "2020-08-12", "has_results": true, "last_update_posted_date": "2022-08-31", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 24, "location_summary": "Phoenix, Arizona • Fullerton, California • Los Angeles, California + 19 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Fullerton", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Norwalk", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT04363736" }, { "nct_id": "NCT00735878", "title": "Pharmacokinetic & Pharmacodynamic Study of ABT-751 With Carboplatin in Patients With Advanced Lung Cancer", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Non Small Cell Lung Cancer", "Lung Cancer" ], "interventions": [ { "name": "ABT-751 and Carboplatin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Konstantin Dragnev", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2004-09", "completion_date": "2009-01", "has_results": true, "last_update_posted_date": "2018-10-12", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 1, "location_summary": "Lebanon, New Hampshire", "locations": [ { "city": "Lebanon", "state": "New Hampshire" } ], "official_url": "https://clinicaltrials.gov/study/NCT00735878" }, { "nct_id": "NCT03525509", "title": "Epidural Methadone in Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Pain, Acute" ], "interventions": [ { "name": "Methadone hydrochloride", "type": "DRUG" }, { "name": "Morphine Sulfate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "simon.haroutounian", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 13, "start_date": "2018-06-04", "completion_date": "2019-08-30", "has_results": false, "last_update_posted_date": "2019-09-18", "last_synced_at": "2026-11-15T16:56:24.795Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT03525509" } ] }