{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Phentermine%2Ftopiramate&page=3", "query": { "intervention": "Phentermine/topiramate", "page": 3 }, "page_size": 10 }, "pagination": { "page": 3, "page_size": 10, "total_count": 49, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Phentermine%2Ftopiramate&page=4&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Phentermine%2Ftopiramate&page=2&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-05T02:00:11.209Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00554216", "title": "Study of VI-0521 Compared to Placebo in Treatment of Obesity in Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obesity" ], "interventions": [ { "name": "VI-0521", "type": "DRUG" }, { "name": "Placebo matched phentermine/topiramate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VIVUS LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 1267, "start_date": "2007-11", "completion_date": "2009-05", "has_results": true, "last_update_posted_date": "2012-09-10", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 5, "location_summary": "San Diego, California • Ridgefield, Connecticut • Durham, North Carolina + 2 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Ridgefield", "state": "Connecticut" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Toledo", "state": "Ohio" }, { "city": "Austin", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00554216" }, { "nct_id": "NCT00806260", "title": "A Study to Evaluate How VI-0521 Affect Psychomotor Performance in Healthy Overweight and Obese Subjects.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Overweight", "Obesity" ], "interventions": [ { "name": "VI-0521", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Alcohol", "type": "OTHER" }, { "name": "alcohol placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "VIVUS LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "21 Years to 45 Years" }, "enrollment_count": 80, "start_date": "2008-12", "completion_date": "2009-05", "has_results": true, "last_update_posted_date": "2013-09-13", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 1, "location_summary": "Lincoln, Nebraska", "locations": [ { "city": "Lincoln", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT00806260" }, { "nct_id": "NCT02635386", "title": "EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Polycystic Ovary Syndrome", "Obesity" ], "interventions": [ { "name": "Exenatide once weekly (EQW )", "type": "DRUG" }, { "name": "Dapagliflozin (DAPA)", "type": "DRUG" }, { "name": "EQW plus DAPA", "type": "DRUG" }, { "name": "Dapagliflozin plus Glucophage (MET ER)", "type": "DRUG" }, { "name": "Phentermine /Topiramate (PHEN/ TPM) ER", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Woman's", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 119, "start_date": "2016-03-22", "completion_date": "2020-10-09", "has_results": true, "last_update_posted_date": "2021-01-29", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 1, "location_summary": "Baton Rouge, Louisiana", "locations": [ { "city": "Baton Rouge", "state": "Louisiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT02635386" }, { "nct_id": "NCT00745251", "title": "A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Sleep Apnea" ], "interventions": [ { "name": "VI-0521", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VIVUS LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "30 Years to 65 Years" }, "enrollment_count": 45, "start_date": "2008-08", "completion_date": "2009-12", "has_results": true, "last_update_posted_date": "2012-10-05", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 1, "location_summary": "Louisville, Kentucky", "locations": [ { "city": "Louisville", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT00745251" }, { "nct_id": "NCT04298203", "title": "Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents With Severe Obesity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Obesity" ], "interventions": [ { "name": "Phentermine-Topiramate", "type": "DRUG" }, { "name": "Meal Replacement Therapy", "type": "DIETARY_SUPPLEMENT" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "University of Minnesota", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "18 Years", "sex": "ALL", "summary": "12 Years to 18 Years" }, "enrollment_count": 100, "start_date": "2021-08-04", "completion_date": "2026-05-22", "has_results": false, "last_update_posted_date": "2026-05-26", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 1, "location_summary": "Minneapolis, Minnesota", "locations": [ { "city": "Minneapolis", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT04298203" }, { "nct_id": "NCT03922945", "title": "A Phase IV Safety and Efficacy Study of VI-0521 in Adolescents With Obesity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Adolescent Obesity", "Obesity in Adolescence", "Adolescent Overweight" ], "interventions": [ { "name": "VI-0521 oral capsule", "type": "DRUG" }, { "name": "Placebo oral capsule", "type": "DRUG" }, { "name": "Lifestyle Modification", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "VIVUS LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "16 Years", "sex": "ALL", "summary": "12 Years to 16 Years" }, "enrollment_count": 223, "start_date": "2019-05-02", "completion_date": "2021-04-16", "has_results": true, "last_update_posted_date": "2022-09-10", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 1, "location_summary": "Norman, Oklahoma", "locations": [ { "city": "Norman", "state": "Oklahoma" } ], "official_url": "https://clinicaltrials.gov/study/NCT03922945" }, { "nct_id": "NCT05579249", "title": "A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Obesity" ], "interventions": [ { "name": "Semaglutide", "type": "DRUG" }, { "name": "Orlistat", "type": "DRUG" }, { "name": "Phentermine/Topiramate", "type": "DRUG" }, { "name": "Naltrexone/Bupropion", "type": "DRUG" }, { "name": "Liraglutide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novo Nordisk A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 500, "start_date": "2023-01-19", "completion_date": "2024-11-27", "has_results": true, "last_update_posted_date": "2026-01-14", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 1, "location_summary": "Loma Linda, California", "locations": [ { "city": "Loma Linda", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05579249" }, { "nct_id": "NCT06299891", "title": "Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypothalamic Obesity", "Hypothalamic Tumor", "Craniopharyngioma" ], "interventions": [ { "name": "Phentermine / Topiramate Extended Release Oral Capsule [Qsymia]", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Seattle Children's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "28 Years", "sex": "ALL", "summary": "6 Years to 28 Years" }, "enrollment_count": 24, "start_date": "2025-03-01", "completion_date": "2026-05-31", "has_results": false, "last_update_posted_date": "2025-07-28", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 2, "location_summary": "Philadelphia, Pennsylvania • Seattle, Washington", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT06299891" }, { "nct_id": "NCT04721873", "title": "Pharmacologic Weight Loss as Adjunct Therapy for Ulcerative Colitis in Obese Patients", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Colitis, Ulcerative", "Obesity" ], "interventions": [ { "name": "Phentermine-Topiramate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Diego", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 40, "start_date": "2020-12-18", "completion_date": "2024-06-30", "has_results": false, "last_update_posted_date": "2023-05-16", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 1, "location_summary": "La Jolla, California", "locations": [ { "city": "La Jolla", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04721873" }, { "nct_id": "NCT00553787", "title": "Study of VI-0521 Compared to Placebo in Treatment of Diabetes and Obesity in Adults With Obesity-Related Co-Morbid Conditions", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obesity", "Type 2 Diabetes" ], "interventions": [ { "name": "VI-0521", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VIVUS LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 2487, "start_date": "2007-11", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2012-09-10", "last_synced_at": "2026-10-05T02:00:11.209Z", "location_count": 6, "location_summary": "Birmingham, Alabama • Ridgefield, Connecticut • New York, New York + 3 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Ridgefield", "state": "Connecticut" }, { "city": "New York", "state": "New York" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Toledo", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00553787" } ] }