{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pioglitazone+and+metformin&page=3", "query": { "intervention": "Pioglitazone and metformin", "page": 3 }, "page_size": 10 }, "pagination": { "page": 3, "page_size": 10, "total_count": 58, "total_pages": 6, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pioglitazone+and+metformin&page=4&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Pioglitazone+and+metformin&page=2&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-09T02:01:21.325Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06446531", "title": "Prevention of Progression of Prediabetes, Obesity and CV Risk", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Pre-Diabetes", "Weight, Body", "Cardiovascular Diseases" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Rybelsus Tablet", "type": "DRUG" }, { "name": "Jardiance 25Mg Tablet", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Actos", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 64, "start_date": "2024-09-11", "completion_date": "2027-07", "has_results": false, "last_update_posted_date": "2025-11-12", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 1, "location_summary": "San Antonio, Texas", "locations": [ { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06446531" }, { "nct_id": "NCT02298192", "title": "A Clinical Trial Comparing Efficacy and Safety of Insulin Degludec/Liraglutide (IDegLira) in Subjects With Type 2 Diabetes Mellitus Using Two Different Titration Algorithms", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "insulin degludec/liraglutide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novo Nordisk A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 420, "start_date": "2014-11-21", "completion_date": "2015-12-23", "has_results": true, "last_update_posted_date": "2017-05-23", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 40, "location_summary": "Hamilton, Alabama • Chandler, Arizona • Glendale, Arizona + 34 more", "locations": [ { "city": "Hamilton", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT02298192" }, { "nct_id": "NCT00744367", "title": "A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Plus Pioglitazone.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus Type 2" ], "interventions": [ { "name": "metformin", "type": "DRUG" }, { "name": "pioglitazone", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" }, { "name": "taspoglutide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 326, "start_date": "2008-10", "completion_date": "2010-11", "has_results": false, "last_update_posted_date": "2016-08-05", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 76, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Muscle Shoals, Alabama + 68 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00744367" }, { "nct_id": "NCT00571519", "title": "Randomized, Double-blind, Active-controlled, Study of Rivoglitazone in Type 2 Diabetes Mellitus", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "rivoglitazone HCl", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" }, { "name": "pioglitazone HCl", "type": "DRUG" }, { "name": "pioglitazone HCl 45 mg", "type": "DRUG" }, { "name": "metformin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Daiichi Sankyo", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 94, "start_date": "2007-11-14", "completion_date": "2008-05-23", "has_results": true, "last_update_posted_date": "2021-05-26", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 18, "location_summary": "Huntsville, Alabama • San Diego, California • San Francisco, California + 14 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Ridgefield", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT00571519" }, { "nct_id": "NCT00637273", "title": "A Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION - 2)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "exenatide once weekly", "type": "DRUG" }, { "name": "sitagliptin", "type": "DRUG" }, { "name": "pioglitazone", "type": "DRUG" }, { "name": "placebo tablet", "type": "DRUG" }, { "name": "placebo once weekly", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 514, "start_date": "2008-01", "completion_date": "2009-07", "has_results": true, "last_update_posted_date": "2015-04-07", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 51, "location_summary": "Peoria, Arizona • Artesia, California • Concord, California + 48 more", "locations": [ { "city": "Peoria", "state": "Arizona" }, { "city": "Artesia", "state": "California" }, { "city": "Concord", "state": "California" }, { "city": "Encino", "state": "California" }, { "city": "Greenbrae", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00637273" }, { "nct_id": "NCT00232583", "title": "Preservation of Beta-cell Function in Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Insulin", "type": "DRUG" }, { "name": "Metfomin", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" }, { "name": "glyburide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "25 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "25 Years to 65 Years" }, "enrollment_count": 58, "start_date": "2003-11", "completion_date": "2011-12", "has_results": true, "last_update_posted_date": "2017-12-14", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 1, "location_summary": "Dallas, Texas", "locations": [ { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00232583" }, { "nct_id": "NCT00909597", "title": "A Study of Taspoglutide Versus Pioglitazone in Patients With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus Type 2" ], "interventions": [ { "name": "pioglitazone", "type": "DRUG" }, { "name": "taspoglutide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 756, "start_date": "2009-05", "completion_date": "2010-11", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 57, "location_summary": "Buena Park, California • Chino, California • Los Angeles, California + 52 more", "locations": [ { "city": "Buena Park", "state": "California" }, { "city": "Chino", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Rancho Cucamonga", "state": "California" }, { "city": "Roseville", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00909597" }, { "nct_id": "NCT00676338", "title": "Safety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "exenatide once weekly", "type": "DRUG" }, { "name": "metformin", "type": "DRUG" }, { "name": "sitagliptin", "type": "DRUG" }, { "name": "pioglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 820, "start_date": "2008-11", "completion_date": "2011-01", "has_results": true, "last_update_posted_date": "2015-04-09", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 18, "location_summary": "Buena Park, California • Los Angeles, California • Valencia, California + 15 more", "locations": [ { "city": "Buena Park", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Valencia", "state": "California" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00676338" }, { "nct_id": "NCT00432276", "title": "Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus" ], "interventions": [ { "name": "Alogliptin", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 803, "start_date": "2007-01", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2013-04-04", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 86, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Lake Havasu City, Arizona + 83 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Lake Havasu City", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Foothill Ranch", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00432276" }, { "nct_id": "NCT02303405", "title": "Hydroxychloroquine Versus Pioglitazone in Combination Treatment for Type 2 Diabetes Mellitus", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetes Mellitus Type 2 With Hyperglycemia" ], "interventions": [ { "name": "Hydroxychloroquine", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Charles Drew University of Medicine and Science", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 22, "start_date": "2014-11", "completion_date": "2017-11", "has_results": true, "last_update_posted_date": "2022-10-20", "last_synced_at": "2026-10-09T02:01:21.325Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02303405" } ] }