{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+%2B+%28lithium+or+divalproex%29", "query": { "intervention": "Placebo + (lithium or divalproex)" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 18, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+%2B+%28lithium+or+divalproex%29&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-04T16:26:06.995Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01284517", "title": "Lurasidone HCI - A 6-week Phase 3 Study of Patients With Bipolar I Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Depression" ], "interventions": [ { "name": "Lurasidone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sumitomo Pharma America, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 356, "start_date": "2010-11", "completion_date": "2012-08", "has_results": true, "last_update_posted_date": "2013-11-26", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 22, "location_summary": "Costa Mesa, California • Riverside, California • San Diego, California + 16 more", "locations": [ { "city": "Costa Mesa", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Ana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01284517" }, { "nct_id": "NCT00081380", "title": "Efficacy and Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Seroquel®, quetiapine fumarate (atypical antipsychotic)", "type": "DRUG" }, { "name": "lithium (mood stabilizer)", "type": "DRUG" }, { "name": "divalproex (mood stabilizer)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 710, "start_date": "2004-03", "completion_date": "2006-09", "has_results": false, "last_update_posted_date": "2008-12-22", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 81, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 78 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Cerritos", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00081380" }, { "nct_id": "NCT00868452", "title": "Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Depression" ], "interventions": [ { "name": "lurasidone + (lithium or divalproex)", "type": "DRUG" }, { "name": "Placebo + (lithium or divalproex)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sumitomo Pharma America, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 348, "start_date": "2009-04", "completion_date": "2012-01", "has_results": true, "last_update_posted_date": "2014-04-17", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 27, "location_summary": "Little Rock, Arkansas • Anaheim, California • Chino, California + 21 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Chino", "state": "California" }, { "city": "Escondido", "state": "California" }, { "city": "Garden Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00868452" }, { "nct_id": "NCT02600507", "title": "Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Depression" ], "interventions": [ { "name": "Lumateperone (ITI-007)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Intra-Cellular Therapies, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 529, "start_date": "2016-03-07", "completion_date": "2020-07-02", "has_results": true, "last_update_posted_date": "2023-05-17", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 42, "location_summary": "Rogers, Arkansas • Cerritos, California • Costa Mesa, California + 39 more", "locations": [ { "city": "Rogers", "state": "Arkansas" }, { "city": "Cerritos", "state": "California" }, { "city": "Costa Mesa", "state": "California" }, { "city": "Culver City", "state": "California" }, { "city": "Garden Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02600507" }, { "nct_id": "NCT01467700", "title": "Efficacy and Safety of Ramelteon Sublingual in Adult Patients With Acute Depressive Episodes Associated With Bipolar I Disorder", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acute Depressive Episode" ], "interventions": [ { "name": "Ramelteon SL", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 490, "start_date": "2011-12", "completion_date": "2015-03", "has_results": true, "last_update_posted_date": "2016-05-16", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 141, "location_summary": "Birmingham, Alabama • Dothan, Alabama • Muscle Shoals, Alabama + 137 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Dothan", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Fayetteville", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01467700" }, { "nct_id": "NCT00183443", "title": "Treatment of Mania Symptoms With Drug Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder", "Schizophrenia" ], "interventions": [ { "name": "Divalproex-extended release (DVP-ER)", "type": "DRUG" }, { "name": "Lithium", "type": "DRUG" }, { "name": "Quetiapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Palo Alto Veterans Institute for Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 75, "start_date": "2005-02", "completion_date": "2010-11", "has_results": true, "last_update_posted_date": "2018-07-17", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 1, "location_summary": "Palo Alto, California", "locations": [ { "city": "Palo Alto", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00183443" }, { "nct_id": "NCT01784666", "title": "Adjunctive Isradipine for the Treatment of Bipolar Depression", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Isradipine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 2, "start_date": "2013-02", "completion_date": "2014-04", "has_results": true, "last_update_posted_date": "2017-04-20", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01784666" }, { "nct_id": "NCT00483548", "title": "Adjunctive Ziprasidone in the Treatment of Bipolar I Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder", "Depression, Bipolar" ], "interventions": [ { "name": "Ziprasidone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 298, "start_date": "2007-10", "completion_date": "2008-12", "has_results": true, "last_update_posted_date": "2021-03-10", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 60, "location_summary": "Chandler, Arizona • Litchfield Park, Arizona • Little Rock, Arkansas + 50 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Springdale", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00483548" }, { "nct_id": "NCT00114686", "title": "Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar I Disorder", "Alcohol Dependence" ], "interventions": [ { "name": "Quetiapine fumarate", "type": "DRUG" }, { "name": "lithium", "type": "DRUG" }, { "name": "divalproex", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "21 Years to 60 Years" }, "enrollment_count": 350, "start_date": "2006-01", "completion_date": "2007-04", "has_results": false, "last_update_posted_date": "2013-01-04", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 38, "location_summary": "Cerritos, California • San Diego, California • New Haven, Connecticut + 35 more", "locations": [ { "city": "Cerritos", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Maitland", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00114686" }, { "nct_id": "NCT06433635", "title": "Sequential Multiple Assignment Randomized Trial for Bipolar Depression", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar I Disorder", "Depression" ], "interventions": [ { "name": "Cariprazine", "type": "DRUG" }, { "name": "Aripiprazole/Escitalopram combination", "type": "DRUG" }, { "name": "Quetiapine", "type": "DRUG" }, { "name": "Lurasidone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 2726, "start_date": "2024-10-01", "completion_date": "2030-02-28", "has_results": false, "last_update_posted_date": "2025-12-16", "last_synced_at": "2026-10-04T16:26:06.995Z", "location_count": 17, "location_summary": "Birmingham, Alabama • Bloomington, Indiana • Baltimore, Maryland + 13 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Bloomington", "state": "Indiana" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Belmont", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT06433635" } ] }