{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+%2B+Methotrexate+%28MTX%29&page=2", "query": { "intervention": "Placebo + Methotrexate (MTX)", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 80, "total_pages": 8, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+%2B+Methotrexate+%28MTX%29&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+%2B+Methotrexate+%28MTX%29&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-03T18:15:05.292Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00042406", "title": "Trial With HuMax-CD4 in Participants With Rheumatoid Arthritis (RA) Failing Treatment With Methotrexate (MTX) and a TNF-alpha Blocker", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Humax-CD4", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Genmab", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 83, "start_date": "2002-03-04", "completion_date": "2003-03-31", "has_results": false, "last_update_posted_date": "2023-04-28", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 50, "location_summary": "Montgomery, Alabama • Long Beach, California • Rancho Cucamonga, California + 45 more", "locations": [ { "city": "Montgomery", "state": "Alabama" }, { "city": "Long Beach", "state": "California" }, { "city": "Rancho Cucamonga", "state": "California" }, { "city": "Rancho Mirage", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00042406" }, { "nct_id": "NCT02833350", "title": "Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "GDC-0853", "type": "DRUG" }, { "name": "Adalimumab", "type": "DRUG" }, { "name": "Folic Acid", "type": "DRUG" }, { "name": "MTX", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Genentech, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 578, "start_date": "2016-09-09", "completion_date": "2018-07-02", "has_results": true, "last_update_posted_date": "2020-06-12", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 23, "location_summary": "Anniston, Alabama • Glendale, Arizona • Covina, California + 18 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Covina", "state": "California" }, { "city": "El Cajon", "state": "California" }, { "city": "Fullerton", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02833350" }, { "nct_id": "NCT00420927", "title": "Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "adalimumab", "type": "BIOLOGICAL" }, { "name": "methotrexate", "type": "DRUG" }, { "name": "placebo", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Abbott", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1032, "start_date": "2006-12", "completion_date": "2010-07", "has_results": true, "last_update_posted_date": "2012-04-18", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 49, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 45 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT00420927" }, { "nct_id": "NCT01999192", "title": "Study to Investigate the Safety and Efficacy of Tregalizumab in Subjects (MTX-IR) With Active Rheumatoid Arthritis", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Tregalizumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Biotest", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 321, "start_date": "2013-10", "completion_date": "2015-07", "has_results": true, "last_update_posted_date": "2017-08-24", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 8, "location_summary": "Paradise Valley, Arizona • Springfield, Illinois • Lincoln, Nebraska + 5 more", "locations": [ { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Springfield", "state": "Illinois" }, { "city": "Lincoln", "state": "Nebraska" }, { "city": "Clifton", "state": "New Jersey" }, { "city": "North Charleston", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01999192" }, { "nct_id": "NCT00105976", "title": "Efficacy Study of MM-093 in Rheumatoid Arthritis Patients on Methotrexate (MTX)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "MM-093", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merrimack Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 260, "start_date": "2005-02", "completion_date": null, "has_results": false, "last_update_posted_date": "2008-07-11", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 38, "location_summary": "Birmingham, Alabama • Montgomery, Alabama • Paradise Valley, Arizona + 33 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Montgomery", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00105976" }, { "nct_id": "NCT00316771", "title": "A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "P38 Inhibitor (4) 150mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 25mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 300mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 50mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 75mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 374, "start_date": "2005-11", "completion_date": "2008-03", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 48, "location_summary": "Birmingham, Alabama • Paradise Valley, Arizona • Tucson, Arizona + 42 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00316771" }, { "nct_id": "NCT00406419", "title": "A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate Treatment (STAGE)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Methotrexate", "type": "DRUG" }, { "name": "ocrelizumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Genentech, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1015, "start_date": "2006-12-27", "completion_date": "2015-04-22", "has_results": true, "last_update_posted_date": "2020-11-27", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 1, "location_summary": "South San Francisco, California", "locations": [ { "city": "South San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00406419" }, { "nct_id": "NCT01217814", "title": "Effect of SAR153191 (REGN88) With Methotrexate in Patients With Active Rheumatoid Arthritis Who Failed TNF-α Blockers", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Sarilumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Golimumab", "type": "DRUG" }, { "name": "methotrexate (MTX)", "type": "DRUG" }, { "name": "Folic/folinic acid", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanofi", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 16, "start_date": "2010-11", "completion_date": "2011-09", "has_results": true, "last_update_posted_date": "2017-09-01", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 4, "location_summary": "Freehold, New Jersey • New York, New York • Jackson, Tennessee + 1 more", "locations": [ { "city": "Freehold", "state": "New Jersey" }, { "city": "New York", "state": "New York" }, { "city": "Jackson", "state": "Tennessee" }, { "city": "Austin", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01217814" }, { "nct_id": "NCT04095858", "title": "Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hematopoietic Stem Cell Transplantation", "Acute Graft Versus Host Disease", "Acute Myeloid Leukemia", "Acute Lymphoblastic Leukemia", "Myelodysplastic Syndromes" ], "interventions": [ { "name": "Efprezimod alfa", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Methotrexate", "type": "DRUG" }, { "name": "Tacrolimus", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Oncoimmune, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 11, "start_date": "2021-01-05", "completion_date": "2021-11-05", "has_results": true, "last_update_posted_date": "2023-02-08", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 4, "location_summary": "Duarte, California • Chicago, Illinois • Hershey, Pennsylvania + 1 more", "locations": [ { "city": "Duarte", "state": "California" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Hershey", "state": "Pennsylvania" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04095858" }, { "nct_id": "NCT01521923", "title": "A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drugs (DMARD)-naïve Adults With Early Active Rheumatoid Arthritis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Certolizumab Pegol + Methotrexate (MTX)", "type": "BIOLOGICAL" }, { "name": "Placebo + Methotrexate (MTX)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "UCB Pharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 359, "start_date": "2012-01", "completion_date": "2015-09", "has_results": true, "last_update_posted_date": "2026-08-25", "last_synced_at": "2026-10-03T18:15:05.292Z", "location_count": 70, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 63 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Paradise Valley", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01521923" } ] }