{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+%2F+Normal+Saline", "query": { "intervention": "Placebo / Normal Saline" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 3187, "total_pages": 319, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+%2F+Normal+Saline&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-14T16:42:24.968Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02416934", "title": "Dysphagia Following Anterior Cervical Spine Surgery; Steroid vs Saline", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dysphagia" ], "interventions": [ { "name": "Treatment 1; Dexamethasone", "type": "DRUG" }, { "name": "Treatment 0; Saline placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "West Virginia University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 74, "start_date": "2012-07", "completion_date": "2017-05-15", "has_results": true, "last_update_posted_date": "2019-02-05", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "Morgantown, West Virginia", "locations": [ { "city": "Morgantown", "state": "West Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02416934" }, { "nct_id": "NCT04299438", "title": "Propranolol Rescue of Prolonged Labor", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pregnancy, Prolonged" ], "interventions": [ { "name": "Propranolol Hydrochloride", "type": "DRUG" }, { "name": "Saline", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Lisa Levine", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "FEMALE", "summary": "16 Years and older · Female only" }, "enrollment_count": 164, "start_date": "2020-07-14", "completion_date": "2022-07-15", "has_results": true, "last_update_posted_date": "2023-08-23", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 2, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04299438" }, { "nct_id": "NCT02448043", "title": "Cutaneous Prostaglandin Application: Nail Growth, Nail Brittleness, and Eye Pressure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Nail Growth Cessation", "Intraocular Pressure" ], "interventions": [ { "name": "Bimatoprost 0.01%", "type": "DRUG" }, { "name": "Placebo: saline", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Northwestern University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 45, "start_date": "2015-06-04", "completion_date": "2016-05-06", "has_results": true, "last_update_posted_date": "2019-12-13", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "Glenview, Illinois", "locations": [ { "city": "Glenview", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02448043" }, { "nct_id": "NCT01260649", "title": "N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major Depression", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "ketamine", "type": "DRUG" }, { "name": "IV Saline", "type": "OTHER" }, { "name": "ECT", "type": "PROCEDURE" }, { "name": "Muscle Relaxant", "type": "DRUG" }, { "name": "Anesthetic Agents", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER", "PROCEDURE" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 17, "start_date": "2010-11-01", "completion_date": "2012-11-01", "has_results": true, "last_update_posted_date": "2017-05-22", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01260649" }, { "nct_id": "NCT04138615", "title": "Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Morphine", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 44, "start_date": "2019-11-12", "completion_date": "2022-01-04", "has_results": true, "last_update_posted_date": "2023-01-12", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "Dallas, Texas", "locations": [ { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04138615" }, { "nct_id": "NCT06406114", "title": "Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Drug Allergy", "Cephalosporin Allergy", "Drug Hypersensitivity", "Antibiotic Allergy", "Beta Lactam Adverse Reaction", "Drug-Induced Anaphylaxis", "Cephalosporin Reaction" ], "interventions": [ { "name": "Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing", "type": "DRUG" }, { "name": "Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge", "type": "DRUG" }, { "name": "Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge", "type": "DRUG" }, { "name": "Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge", "type": "DRUG" }, { "name": "Amoxicillin double-blind placebo-controlled drug challenge", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 300, "start_date": "2025-05-05", "completion_date": "2028-12-31", "has_results": false, "last_update_posted_date": "2026-09-04", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 6, "location_summary": "Scottsdale, Arizona • San Francisco, California • Boston, Massachusetts + 3 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "San Francisco", "state": "California" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Rochester", "state": "New York" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT06406114" }, { "nct_id": "NCT00801138", "title": "The Effect of Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine or Bupivacaine", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Anesthesia, Local", "Shoulder Surgery" ], "interventions": [ { "name": "saline", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "ropivacaine", "type": "DRUG" }, { "name": "Bupivacaine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 218, "start_date": "2008-11", "completion_date": "2010-11", "has_results": true, "last_update_posted_date": "2017-05-01", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00801138" }, { "nct_id": "NCT04270526", "title": "Minimizing Pain During Office Intradetrussor Botox Injection", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Overactive Bladder", "Overactive Detrusor", "Overactive Bladder Syndrome", "Overactivity; Behavior", "Urge Incontinence" ], "interventions": [ { "name": "Bicarbonate protocol", "type": "DRUG" }, { "name": "Standard protocol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Boston Urogynecology Associates", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 85, "start_date": "2020-08-15", "completion_date": "2023-06-30", "has_results": true, "last_update_posted_date": "2025-03-06", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "Cambridge, Massachusetts", "locations": [ { "city": "Cambridge", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04270526" }, { "nct_id": "NCT03389685", "title": "Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "ACL - Anterior Cruciate Ligament Rupture", "ACL Injury" ], "interventions": [ { "name": "Platelet Rich Plasma", "type": "BIOLOGICAL" }, { "name": "Saline Placebo", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "NYU Langone Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 0, "start_date": "2018-09-09", "completion_date": "2024-02", "has_results": false, "last_update_posted_date": "2024-04-15", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03389685" }, { "nct_id": "NCT06580509", "title": "TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Hemorrhage, Surgical", "Tonsillar Bleeding" ], "interventions": [ { "name": "Tranexamic Acid Injectable Product", "type": "DRUG" }, { "name": "Normal Saline", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "2 Years to 17 Years" }, "enrollment_count": 12, "start_date": "2026-02-18", "completion_date": "2028-09-30", "has_results": false, "last_update_posted_date": "2026-04-24", "last_synced_at": "2026-09-14T16:42:24.968Z", "location_count": 1, "location_summary": "San Antonio, Texas", "locations": [ { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06580509" } ] }