{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+-+Losartan",
    "query": {
      "intervention": "Placebo - Losartan"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 46,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+-+Losartan&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-22T06:34:07.026Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00381134",
      "title": "Improving Outcomes in Patients With Kidney Disease Due to Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Diabetes",
        "Kidney Disease",
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "losartan 100 mg orally once daily",
          "type": "DRUG"
        },
        {
          "name": "spironolactone 25 mg orally once daily",
          "type": "DRUG"
        },
        {
          "name": "placebo once orally once daily",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 92,
      "start_date": "2003-07",
      "completion_date": "2006-12",
      "has_results": false,
      "last_update_posted_date": "2010-03-02",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00381134"
    },
    {
      "nct_id": "NCT02049307",
      "title": "Losartan to Reduce Inflammation and Fibrosis Endpoints in HIV Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Inflammation",
        "Fibrosis"
      ],
      "interventions": [
        {
          "name": "Losartan 100mg daily",
          "type": "DRUG"
        },
        {
          "name": "Matching placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hennepin Healthcare Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 108,
      "start_date": "2014-10-16",
      "completion_date": "2018-12-14",
      "has_results": true,
      "last_update_posted_date": "2019-12-10",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 4,
      "location_summary": "San Francisco, California • Bethesda, Maryland • Minneapolis, Minnesota",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02049307"
    },
    {
      "nct_id": "NCT07135687",
      "title": "Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "ACL Injury",
        "ACL Reconstruction",
        "Scar Formation"
      ],
      "interventions": [
        {
          "name": "Losartan",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 144,
      "start_date": "2026-08",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-15",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07135687"
    },
    {
      "nct_id": "NCT02232880",
      "title": "Treatment of Resistant Hypertension by Prevention of T-Cell Co-Stimulation",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Abatacept",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 1,
      "start_date": "2014-08",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2017-02-07",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02232880"
    },
    {
      "nct_id": "NCT03467217",
      "title": "Losartan for the Treatment of Pediatric NAFLD",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "NAFLD - Nonalcoholic Fatty Liver Disease"
      ],
      "interventions": [
        {
          "name": "Losartan potassium",
          "type": "DRUG"
        },
        {
          "name": "Placebo losartan capsule",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "8 Years to 17 Years"
      },
      "enrollment_count": 83,
      "start_date": "2018-10-02",
      "completion_date": "2020-06-30",
      "has_results": true,
      "last_update_posted_date": "2021-10-21",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 10,
      "location_summary": "San Diego, California • San Francisco, California • Atlanta, Georgia + 7 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03467217"
    },
    {
      "nct_id": "NCT01150461",
      "title": "Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypertrophic Cardiomyopathy"
      ],
      "interventions": [
        {
          "name": "losartan",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2007-02",
      "completion_date": "2010-07",
      "has_results": true,
      "last_update_posted_date": "2013-09-05",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01150461"
    },
    {
      "nct_id": "NCT00340678",
      "title": "Renoprotection in Early Diabetic Nephropathy in Pima Indians",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Diabetic Nephropathy"
      ],
      "interventions": [
        {
          "name": "Losartan",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 170,
      "start_date": "1995-08",
      "completion_date": "2014-03",
      "has_results": true,
      "last_update_posted_date": "2021-03-25",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00340678"
    },
    {
      "nct_id": "NCT06108063",
      "title": "Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Knee Arthroplasty, Total"
      ],
      "interventions": [
        {
          "name": "Losartan",
          "type": "DRUG"
        },
        {
          "name": "Placebo - Losartan",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Steadman Philippon Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2024-03-06",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-03-12",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Vail, Colorado",
      "locations": [
        {
          "city": "Vail",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06108063"
    },
    {
      "nct_id": "NCT05637216",
      "title": "Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Radiation Induced Fibrosis"
      ],
      "interventions": [
        {
          "name": "Losartan 25 milligram capsule",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Shaw Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 43,
      "start_date": "2023-08-17",
      "completion_date": "2027-08-17",
      "has_results": false,
      "last_update_posted_date": "2026-06-18",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Edwards, Colorado",
      "locations": [
        {
          "city": "Edwards",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05637216"
    },
    {
      "nct_id": "NCT00223717",
      "title": "Treatment of Supine Hypertension in Autonomic Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Clonidine",
          "type": "DRUG"
        },
        {
          "name": "Nitroglycerin transdermal",
          "type": "DRUG"
        },
        {
          "name": "Dipyridamole/ Aspirin (Aggrenox)",
          "type": "DRUG"
        },
        {
          "name": "Desmopressin (DDAVP)",
          "type": "DRUG"
        },
        {
          "name": "Sildenafil",
          "type": "DRUG"
        },
        {
          "name": "Nifedipine",
          "type": "DRUG"
        },
        {
          "name": "Hydralazine",
          "type": "DRUG"
        },
        {
          "name": "Hydrochlorothiazide",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Bosentan",
          "type": "DRUG"
        },
        {
          "name": "Diltiazem",
          "type": "DRUG"
        },
        {
          "name": "Eplerenone",
          "type": "DRUG"
        },
        {
          "name": "guanfacine",
          "type": "DRUG"
        },
        {
          "name": "L-arginine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "captopril",
          "type": "DRUG"
        },
        {
          "name": "carbidopa",
          "type": "DRUG"
        },
        {
          "name": "losartan",
          "type": "DRUG"
        },
        {
          "name": "metoprolol tartrate",
          "type": "DRUG"
        },
        {
          "name": "nebivolol hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "prazosin hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "tamsulosin hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Head-up tilt.",
          "type": "OTHER"
        },
        {
          "name": "aliskiren",
          "type": "DRUG"
        },
        {
          "name": "Local heat stress",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 152,
      "start_date": "2001-01",
      "completion_date": "2017-01",
      "has_results": false,
      "last_update_posted_date": "2017-10-13",
      "last_synced_at": "2026-09-22T06:34:07.026Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00223717"
    }
  ]
}