{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Comparator%3A+Placebo-controlled+antidepressant+treatment&page=2", "query": { "intervention": "Placebo Comparator: Placebo-controlled antidepressant treatment", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 231, "total_pages": 24, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Comparator%3A+Placebo-controlled+antidepressant+treatment&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Comparator%3A+Placebo-controlled+antidepressant+treatment&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-11T20:11:26.507Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00051272", "title": "Effects Of Antidepressants On Sexual Functioning In Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder (MDD)" ], "interventions": [ { "name": "Extended-release Bupropion Hydrochloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 425, "start_date": "2003-01", "completion_date": "2004-06", "has_results": false, "last_update_posted_date": "2011-03-29", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 24, "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Berkeley, California + 19 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Berkeley", "state": "California" }, { "city": "Middletown", "state": "Connecticut" }, { "city": "Wilmington", "state": "Delaware" } ], "official_url": "https://clinicaltrials.gov/study/NCT00051272" }, { "nct_id": "NCT02418585", "title": "A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Treatment-resistant Depression" ], "interventions": [ { "name": "Esketamine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Duloxetine (Oral Antidepressant)", "type": "DRUG" }, { "name": "Escitalopram (Oral antidepressant)", "type": "DRUG" }, { "name": "Sertraline (Oral Antidepressant)", "type": "DRUG" }, { "name": "Venlafaxine Extended Release (XR) (Oral Antidepressant)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 236, "start_date": "2015-08-07", "completion_date": "2017-11-06", "has_results": true, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 10, "location_summary": "Birmingham, Alabama • Orange, California • San Rafael, California + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Orange", "state": "California" }, { "city": "San Rafael", "state": "California" }, { "city": "Maitland", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02418585" }, { "nct_id": "NCT00406952", "title": "Study for Evaluating Different Methods of Measuring Depression Treatment Response", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "electronic diary", "type": "PROCEDURE" }, { "name": "Sertraline", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "voice acoustics", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 165, "start_date": "2006-11", "completion_date": "2007-08", "has_results": false, "last_update_posted_date": "2008-08-21", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 12, "location_summary": "Norwich, Connecticut • Aventura, Florida • Jacksonville, Florida + 7 more", "locations": [ { "city": "Norwich", "state": "Connecticut" }, { "city": "Aventura", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00406952" }, { "nct_id": "NCT00683852", "title": "A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Aripiprazole 5mg", "type": "DRUG" }, { "name": "Aripiprazole 2mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 225, "start_date": "2008-09", "completion_date": "2009-09", "has_results": true, "last_update_posted_date": "2017-07-19", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00683852" }, { "nct_id": "NCT00429260", "title": "A Study Evaluating the Safety and Tolerability of Abrupt Discontinuation of Saredutant in Patients With Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder" ], "interventions": [ { "name": "Saredutant", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanofi", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 125, "start_date": "2007-01", "completion_date": "2007-06", "has_results": false, "last_update_posted_date": "2012-02-17", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 1, "location_summary": "Malvern, Pennsylvania", "locations": [ { "city": "Malvern", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00429260" }, { "nct_id": "NCT03434041", "title": "A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Treatment-Resistant" ], "interventions": [ { "name": "Esketamine 56 mg", "type": "DRUG" }, { "name": "Esketamine 84 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Duloxetine (Oral Antidepressant)", "type": "DRUG" }, { "name": "Escitalopram (Oral Antidepressant)", "type": "DRUG" }, { "name": "Sertraline (Oral Antidepressant)", "type": "DRUG" }, { "name": "Venlafaxine Extended Release (XR) (Oral Antidepressant)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 252, "start_date": "2018-05-25", "completion_date": "2021-04-13", "has_results": true, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 6, "location_summary": "Atlanta, Georgia • Shreveport, Louisiana • Gaithersburg, Maryland + 3 more", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Shreveport", "state": "Louisiana" }, { "city": "Gaithersburg", "state": "Maryland" }, { "city": "Watertown", "state": "Massachusetts" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03434041" }, { "nct_id": "NCT04533529", "title": "A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Seltorexant", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "74 Years", "sex": "ALL", "summary": "18 Years to 74 Years" }, "enrollment_count": 588, "start_date": "2020-09-16", "completion_date": "2024-04-30", "has_results": true, "last_update_posted_date": "2026-05-12", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 51, "location_summary": "Anaheim, California • Cerritos, California • Irvine, California + 42 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Cerritos", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "La Habra", "state": "California" }, { "city": "Lemon Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04533529" }, { "nct_id": "NCT00200902", "title": "Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression" ], "interventions": [ { "name": "Venlafaxine (Effexor), Duloxetine (Cymbalta), Escitalopram (Lexapro)", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" }, { "name": "Interpersonal Clinical Interaction (ICI)", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "OTHER", "BEHAVIORAL" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 88, "start_date": "2005-08", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2024-08-13", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00200902" }, { "nct_id": "NCT03869736", "title": "Nitrous Oxide for the Treatment of Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Depression", "Major Depressive Disorder" ], "interventions": [ { "name": "Nitrous Oxide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bayside Health", "sponsor_class": "OTHER_GOV", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 81, "start_date": "2019-01-22", "completion_date": "2023-12-10", "has_results": false, "last_update_posted_date": "2024-12-16", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03869736" }, { "nct_id": "NCT00220701", "title": "Escitalopram in the Treatment of Dysthymic Disorder, Double Blind", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Dysthymic Disorder" ], "interventions": [ { "name": "Lexapro (escitalopram)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Luke's-Roosevelt Hospital Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 36, "start_date": "2002-06", "completion_date": "2009-01", "has_results": true, "last_update_posted_date": "2015-11-11", "last_synced_at": "2026-10-11T20:11:26.507Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00220701" } ] }