{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Control+Dentifrice", "query": { "intervention": "Placebo Control Dentifrice" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 36, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Control+Dentifrice&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-12T08:39:35.244Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00708097", "title": "In Situ Caries Efficacy of Fluoride Toothpastes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Caries" ], "interventions": [ { "name": "NaF", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "NaMFP", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "78 Years", "sex": "ALL", "summary": "18 Years to 78 Years" }, "enrollment_count": 57, "start_date": "2008-04", "completion_date": "2008-07", "has_results": true, "last_update_posted_date": "2015-01-01", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT00708097" }, { "nct_id": "NCT03383783", "title": "Evaluation of the Fluoride Dose Response of a Modified In Situ Caries Model", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Caries" ], "interventions": [ { "name": "0 ppm F (placebo, negative control)", "type": "DRUG" }, { "name": "250 ppm F as NaF (dose-response control)", "type": "DRUG" }, { "name": "500 ppm F as NaF (dose-response control)", "type": "DRUG" }, { "name": "1100 ppm F as NaF (positive control)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Domenick Zero", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 28, "start_date": "2017-12-19", "completion_date": "2018-05-02", "has_results": true, "last_update_posted_date": "2019-05-20", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT03383783" }, { "nct_id": "NCT07029438", "title": "Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Dental Plaque", "Gingivitis" ], "interventions": [ { "name": "Mouthwash", "type": "DRUG" }, { "name": "Floss", "type": "DEVICE" }, { "name": "Toothbrush", "type": "DEVICE" }, { "name": "Toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Colgate Palmolive", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 228, "start_date": "2025-07-07", "completion_date": "2025-10-16", "has_results": false, "last_update_posted_date": "2025-10-30", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07029438" }, { "nct_id": "NCT02113579", "title": "Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dentin Sensitivity" ], "interventions": [ { "name": "Experimental Mouth Rinse 12027-033", "type": "DEVICE" }, { "name": "Placebo Mouth Rinse", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 375, "start_date": "2014-03", "completion_date": "2014-05", "has_results": true, "last_update_posted_date": "2015-06-10", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 2, "location_summary": "Fort Wayne, Indiana • Las Vegas, Nevada", "locations": [ { "city": "Fort Wayne", "state": "Indiana" }, { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT02113579" }, { "nct_id": "NCT04763044", "title": "Evaluation of the Fluoride Dose Response Using In Situ Caries Model", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Caries" ], "interventions": [ { "name": "0 ppm F", "type": "DRUG" }, { "name": "250 ppm F as MFP", "type": "DRUG" }, { "name": "1100 ppm as MFP", "type": "DRUG" }, { "name": "2800 ppm F as MFP", "type": "DRUG" }, { "name": "1100 ppm SnF2", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 15, "start_date": "2021-03-01", "completion_date": "2021-07-21", "has_results": true, "last_update_posted_date": "2022-07-19", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04763044" }, { "nct_id": "NCT01657903", "title": "Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Erosion", "Acid Wear" ], "interventions": [ { "name": "Sodium Fluoride", "type": "DRUG" }, { "name": "Potassium nitrate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 56, "start_date": "2011-11", "completion_date": "2012-02", "has_results": true, "last_update_posted_date": "2015-01-26", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT01657903" }, { "nct_id": "NCT02999230", "title": "Probiotics That Moderate pH and Antagonize Pathogens to Promote Oral Health", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Caries Free 1.5% Arginine", "type": "OTHER" }, { "name": "Caries Free Placebo Sodium Fluoride", "type": "OTHER" }, { "name": "Caries Active 1.5% Arginine", "type": "OTHER" }, { "name": "Caries Active- Placebo Sodium Fluoride", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 170, "start_date": "2017-02-22", "completion_date": "2020-06-25", "has_results": false, "last_update_posted_date": "2024-10-01", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02999230" }, { "nct_id": "NCT07215767", "title": "Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dentin Hypersensitivity" ], "interventions": [ { "name": "Stannous fluoride and Potassium nitrate Dentifrice", "type": "DRUG" }, { "name": "Stannous fluoride Dentifrice", "type": "DRUG" }, { "name": "Potassium nitrate Dentifrice", "type": "DRUG" }, { "name": "Vehicle Dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "12 Years to 65 Years" }, "enrollment_count": 688, "start_date": "2025-09-16", "completion_date": "2026-08-11", "has_results": false, "last_update_posted_date": "2026-08-25", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 3, "location_summary": "Melbourne, Florida • Fort Wayne, Indiana • Las Vegas, Nevada", "locations": [ { "city": "Melbourne", "state": "Florida" }, { "city": "Fort Wayne", "state": "Indiana" }, { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT07215767" }, { "nct_id": "NCT01224158", "title": "Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Devices, Home Care" ], "interventions": [ { "name": "Experimental Power Toothbrush", "type": "DEVICE" }, { "name": "Flat trimmed Manual Toothbrush", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 153, "start_date": "2010-09-13", "completion_date": "2010-10-29", "has_results": true, "last_update_posted_date": "2019-12-04", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT01224158" }, { "nct_id": "NCT01657877", "title": "Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Caries" ], "interventions": [ { "name": "Calcium sodium phosphosilicate", "type": "DRUG" }, { "name": "Sodium monoflurophosphate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 100, "start_date": "2012-05", "completion_date": "2013-06", "has_results": true, "last_update_posted_date": "2014-10-01", "last_synced_at": "2026-09-12T08:39:35.244Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT01657877" } ] }