{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Drug%3A+Metformin", "query": { "intervention": "Placebo Drug: Metformin" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 137, "total_pages": 14, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Drug%3A+Metformin&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-26T14:41:34.909Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01549964", "title": "Comparison of Fasiglifam (TAK-875) to Placebo and Sitagliptin in Combination With Metformin in Participants With Type 2 Diabetes", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Glycemic Control" ], "interventions": [ { "name": "Fasiglifam (TAK-875)", "type": "DRUG" }, { "name": "Sitagliptin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 916, "start_date": "2012-04", "completion_date": "2014-03", "has_results": true, "last_update_posted_date": "2016-06-02", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 58, "location_summary": "Muscle Shoals, Alabama • Mesa, Arizona • Peoria, Arizona + 55 more", "locations": [ { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Chula Vista", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01549964" }, { "nct_id": "NCT02229383", "title": "Phase III Study to Evaluate Safety and Efficacy of Added Exenatide Versus Placebo to Titrated Basal Insulin Glargine in Inadequately Controlled Patients With Type II Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus" ], "interventions": [ { "name": "Exenatide", "type": "DRUG" }, { "name": "Exenatide matching placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "130 Years", "sex": "ALL", "summary": "18 Years to 130 Years" }, "enrollment_count": 464, "start_date": "2014-09-06", "completion_date": "2016-08-29", "has_results": true, "last_update_posted_date": "2019-01-08", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 68, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Muscle Shoals, Alabama + 56 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Chino", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02229383" }, { "nct_id": "NCT00111631", "title": "A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetes Mellitus Type 2" ], "interventions": [ { "name": "DPP-IV Inhibitor", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 218, "start_date": "2005-05", "completion_date": "2006-10", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 20, "location_summary": "Concord, California • Salinas, California • San Diego, California + 17 more", "locations": [ { "city": "Concord", "state": "California" }, { "city": "Salinas", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Boulder", "state": "Colorado" }, { "city": "Newark", "state": "Delaware" } ], "official_url": "https://clinicaltrials.gov/study/NCT00111631" }, { "nct_id": "NCT02932475", "title": "Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes", "Pregnancy" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 831, "start_date": "2017-05-25", "completion_date": "2022-06-15", "has_results": true, "last_update_posted_date": "2023-06-26", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 10, "location_summary": "Birmingham, Alabama • San Diego, California • Jackson, Mississippi + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "San Diego", "state": "California" }, { "city": "Jackson", "state": "Mississippi" }, { "city": "New York", "state": "New York" }, { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02932475" }, { "nct_id": "NCT03686657", "title": "Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Type 2 Diabetes", "High Blood Pressure", "Arthritis", "Obesity" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Val, Cel and Met XR Low", "type": "DRUG" }, { "name": "Val, Cel and Met XR High", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "ARKAY Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 0, "start_date": "2026-12-10", "completion_date": "2031-01-31", "has_results": false, "last_update_posted_date": "2026-07-16", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 1, "location_summary": "Albany, New York", "locations": [ { "city": "Albany", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03686657" }, { "nct_id": "NCT00667732", "title": "How Glargine Insulin, Oral Diabetes Medications and Exenatide May Improve Blood Sugar Control and Weight Gain in Type 2 Diabetics", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Type 2 Diabetes" ], "interventions": [ { "name": "exenatide", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Oregon Health and Science University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "30 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "30 Years to 70 Years" }, "enrollment_count": 41, "start_date": "2007-03", "completion_date": "2010-04", "has_results": true, "last_update_posted_date": "2013-02-06", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 3, "location_summary": "Washington D.C., District of Columbia • Rochester, Minnesota • Portland, Oregon", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Rochester", "state": "Minnesota" }, { "city": "Portland", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT00667732" }, { "nct_id": "NCT01023581", "title": "Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Alogliptin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Alogliptin Placebo", "type": "DRUG" }, { "name": "Metformin Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 784, "start_date": "2009-11", "completion_date": "2011-06", "has_results": true, "last_update_posted_date": "2013-03-26", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 109, "location_summary": "Dothan, Alabama • Muscle Shoals, Alabama • Pell City, Alabama + 106 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Pell City", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01023581" }, { "nct_id": "NCT05065372", "title": "MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Type 1 Diabetes", "Diabetic Kidney Disease", "Cardiovascular Diseases", "Endothelial Dysfunction", "Insulin Sensitivity" ], "interventions": [ { "name": "Metformin Hcl 1000Mg Tab", "type": "DRUG" }, { "name": "Aminohippurate Sodium 20 % Injection", "type": "DRUG" }, { "name": "Iohexol 300 Mg/mL Injectable Solution", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Kalie Tommerdahl", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "25 Years", "sex": "ALL", "summary": "12 Years to 25 Years" }, "enrollment_count": 60, "start_date": "2022-07-01", "completion_date": "2027-07-31", "has_results": false, "last_update_posted_date": "2025-06-13", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 2, "location_summary": "Aurora, Colorado • Seattle, Washington", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT05065372" }, { "nct_id": "NCT01241669", "title": "Randomized, Placebo-controlled Study to Evaluate Effects of E5555 on Renal Function Parameters and OCT2 Activity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Subjects" ], "interventions": [ { "name": "E5555", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eisai Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 104, "start_date": "2010-10", "completion_date": null, "has_results": false, "last_update_posted_date": "2014-07-11", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01241669" }, { "nct_id": "NCT05762471", "title": "Phase 1b/2a Study of GSBR-1290 in Adult Overweight or Obese Healthy Subjects and Subjects With Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Overweight or Obesity", "Type2 Diabetes Mellitus" ], "interventions": [ { "name": "GSBR-1290", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 142, "start_date": "2023-01-09", "completion_date": "2024-04-11", "has_results": false, "last_update_posted_date": "2024-04-25", "last_synced_at": "2026-09-26T14:41:34.909Z", "location_count": 4, "location_summary": "Anaheim, California • Chula Vista, California • Miami, Florida + 1 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Chula Vista", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Port Orange", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05762471" } ] }