{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Ketamine&page=2", "query": { "intervention": "Placebo Ketamine", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 230, "total_pages": 23, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Ketamine&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+Ketamine&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-02T04:43:25.954Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03844906", "title": "A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteer" ], "interventions": [ { "name": "SAGE-718", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Supernus Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 40, "start_date": "2018-12-27", "completion_date": "2019-04-01", "has_results": false, "last_update_posted_date": "2025-09-17", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 2, "location_summary": "Long Beach, California • Berlin, New Jersey", "locations": [ { "city": "Long Beach", "state": "California" }, { "city": "Berlin", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT03844906" }, { "nct_id": "NCT04177706", "title": "Ketamine for the Treatment of Opioid Use Disorder and Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Depression", "Opioid-use Disorder", "Opioid Abuse" ], "interventions": [ { "name": "Ketamine Hydrochloride", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Medical University of South Carolina", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 21, "start_date": "2020-12-17", "completion_date": "2022-11-21", "has_results": true, "last_update_posted_date": "2024-08-07", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 1, "location_summary": "Charleston, South Carolina", "locations": [ { "city": "Charleston", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT04177706" }, { "nct_id": "NCT00768430", "title": "Optimization of IV Ketamine for Treatment Resistant Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Major Depressive Disorder (MDD)", "Treatment Resistant Depression (TRD)" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Midazolam", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Baylor College of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "21 Years to 80 Years" }, "enrollment_count": 73, "start_date": "2008-11", "completion_date": "2012-11", "has_results": true, "last_update_posted_date": "2014-01-31", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 2, "location_summary": "New York, New York • Houston, Texas", "locations": [ { "city": "New York", "state": "New York" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00768430" }, { "nct_id": "NCT00504725", "title": "Ketamine In Thoracic Surgery (KITS) Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Lung Cancer" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "0.9% saline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 40, "start_date": "2007-07", "completion_date": "2007-12", "has_results": true, "last_update_posted_date": "2014-07-25", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00504725" }, { "nct_id": "NCT01613820", "title": "Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Scopolamine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 0, "start_date": "2015-09", "completion_date": "2017-02", "has_results": false, "last_update_posted_date": "2018-02-19", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01613820" }, { "nct_id": "NCT01892189", "title": "Effects of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Psychotic-Like Symptoms in Healthy Male Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Ketamine-Induced Brain Activity Changes", "Psychotic-like Symptoms" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "TAK-063", "type": "DRUG" }, { "name": "TAK-063 Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "MALE", "summary": "18 Years to 45 Years · Male only" }, "enrollment_count": 27, "start_date": "2013-08", "completion_date": "2014-08", "has_results": true, "last_update_posted_date": "2026-05-08", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT01892189" }, { "nct_id": "NCT03770780", "title": "A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteer" ], "interventions": [ { "name": "SAGE-718", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Supernus Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 19, "start_date": "2018-11-12", "completion_date": "2019-03-22", "has_results": false, "last_update_posted_date": "2025-09-17", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 2, "location_summary": "Long Beach, California • Berlin, New Jersey", "locations": [ { "city": "Long Beach", "state": "California" }, { "city": "Berlin", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT03770780" }, { "nct_id": "NCT00833755", "title": "Effect of Ketamine on Opioid-Induced Hyperalgesia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Pain", "Chronic Pain", "Hyperalgesia" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Placebos", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 79, "start_date": "2008-09", "completion_date": "2016-04", "has_results": true, "last_update_posted_date": "2020-07-23", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00833755" }, { "nct_id": "NCT03539887", "title": "Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Suicidal Ideation", "Depression", "Alcohol Abuse" ], "interventions": [ { "name": "Intranasal ketamine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "21 Years to 60 Years" }, "enrollment_count": 33, "start_date": "2018-05-01", "completion_date": "2022-01-15", "has_results": true, "last_update_posted_date": "2023-03-01", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03539887" }, { "nct_id": "NCT01749098", "title": "A Study To Examine The Effects Of PF-04958242 On Ketamine-Induced Cognitive Impairment In Healthy Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "PF-04958242", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Biogen", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "45 Years", "sex": "MALE", "summary": "21 Years to 45 Years · Male only" }, "enrollment_count": 29, "start_date": "2012-12", "completion_date": "2014-02", "has_results": false, "last_update_posted_date": "2019-11-21", "last_synced_at": "2026-10-02T04:43:25.954Z", "location_count": 2, "location_summary": "New Haven, Connecticut • West Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" }, { "city": "West Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT01749098" } ] }