{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+comparator+to+XR+tablet", "query": { "intervention": "Placebo comparator to XR tablet" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 48, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+comparator+to+XR+tablet&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-28T08:43:43.148Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00631748", "title": "Quetiapine for the Reduction of Cocaine Use", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cocaine Dependence", "Cocaine Abuse", "Cocaine Addiction", "Drug Abuse", "Substance Abuse" ], "interventions": [ { "name": "quetiapine fumarate", "type": "DRUG" }, { "name": "Matched Placebo", "type": "DRUG" }, { "name": "Cognitive-behavioral Therapy", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Seattle Institute for Biomedical and Clinical Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 60, "start_date": "2008-02", "completion_date": "2010-07", "has_results": true, "last_update_posted_date": "2014-03-31", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 1, "location_summary": "Tacoma, Washington", "locations": [ { "city": "Tacoma", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00631748" }, { "nct_id": "NCT00635531", "title": "A Study to Evaluate the Use of Extended Release Alprazolam in the Treatment of Adolescents With Panic Disorder", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Panic Disorder" ], "interventions": [ { "name": "placebo", "type": "OTHER" }, { "name": "alprazolam XR", "type": "DRUG" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "13 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "13 Years to 17 Years" }, "enrollment_count": 16, "start_date": "2004-04", "completion_date": "2004-09", "has_results": false, "last_update_posted_date": "2021-01-28", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 18, "location_summary": "Hialeah, Florida • Jacksonville, Florida • North Miami, Florida + 15 more", "locations": [ { "city": "Hialeah", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "North Miami", "state": "Florida" }, { "city": "Boise", "state": "Idaho" }, { "city": "Terre Haute", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT00635531" }, { "nct_id": "NCT01023581", "title": "Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Alogliptin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Alogliptin Placebo", "type": "DRUG" }, { "name": "Metformin Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 784, "start_date": "2009-11", "completion_date": "2011-06", "has_results": true, "last_update_posted_date": "2013-03-26", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 109, "location_summary": "Dothan, Alabama • Muscle Shoals, Alabama • Pell City, Alabama + 106 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Pell City", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01023581" }, { "nct_id": "NCT02915198", "title": "Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Prediabetic State", "Atherosclerosis", "Metformin" ], "interventions": [ { "name": "Metformin XR", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 7410, "start_date": "2023-04-03", "completion_date": "2029-09-28", "has_results": false, "last_update_posted_date": "2025-12-17", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 40, "location_summary": "Phoenix, Arizona • Tucson, Arizona • Little Rock, Arkansas + 37 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Loma Linda", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02915198" }, { "nct_id": "NCT00428090", "title": "Rosiglitazone (Extended Release Tablets) As Monotherapy In Subjects With Mild To Moderate Alzheimer's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "Rosiglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "50 Years to 90 Years" }, "enrollment_count": 862, "start_date": "2007-02-27", "completion_date": "2008-09-05", "has_results": true, "last_update_posted_date": "2017-05-19", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 41, "location_summary": "Phoenix, Arizona • Los Angeles, California • Newport Beach, California + 34 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Reseda", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00428090" }, { "nct_id": "NCT01810380", "title": "Brexpiprazole in Patients With Acute Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Brexpiprazole", "type": "DRUG" }, { "name": "Quetiapine extended release", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "H. Lundbeck A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 468, "start_date": "2013-03", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2017-03-16", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 1, "location_summary": "Escondido, California", "locations": [ { "city": "Escondido", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01810380" }, { "nct_id": "NCT00772603", "title": "Evaluation of Efficacy and Safety of OXC XR as Adjunctive Therapy for Partial Seizures", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Epilepsies, Partial" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "2400mg SPN-804", "type": "DRUG" }, { "name": "1200mg SPN-804", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Supernus Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 366, "start_date": "2008-11", "completion_date": "2010-11", "has_results": true, "last_update_posted_date": "2014-02-11", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 23, "location_summary": "Huntsville, Alabama • Northport, Alabama • Phoenix, Arizona + 20 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Northport", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00772603" }, { "nct_id": "NCT01379469", "title": "Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Alpha-1-antitrypsin Deficiency", "Liver Cirrhosis" ], "interventions": [ { "name": "Drug-Carbamazepine (Tegretol XR)", "type": "DRUG" }, { "name": "Carbamazepine (Tegretol XR) Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "14 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "14 Years to 80 Years" }, "enrollment_count": 20, "start_date": "2012-01", "completion_date": "2017-02", "has_results": true, "last_update_posted_date": "2021-10-12", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 3, "location_summary": "St Louis, Missouri • Pittsburgh, Pennsylvania", "locations": [ { "city": "St Louis", "state": "Missouri" }, { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01379469" }, { "nct_id": "NCT03538691", "title": "A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Brexpiprazole", "type": "DRUG" }, { "name": "Antidepressant therapy", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1149, "start_date": "2018-07-13", "completion_date": "2022-07-29", "has_results": true, "last_update_posted_date": "2023-10-12", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03538691" }, { "nct_id": "NCT00859898", "title": "Study of Dapagliflozin in Combination With Metformin XR to Initiate the Treatment of Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "Dapagliflozin", "type": "DRUG" }, { "name": "Metformin XR", "type": "DRUG" }, { "name": "dapagliflozin matching Placebo", "type": "DRUG" }, { "name": "metformin HCl Modified Release matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "77 Years", "sex": "ALL", "summary": "18 Years to 77 Years" }, "enrollment_count": 1093, "start_date": "2009-04", "completion_date": "2010-05", "has_results": true, "last_update_posted_date": "2016-07-07", "last_synced_at": "2026-09-28T08:43:43.148Z", "location_count": 64, "location_summary": "Ozark, Alabama • Tempe, Arizona • Concord, California + 53 more", "locations": [ { "city": "Ozark", "state": "Alabama" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Tempe", "state": "Arizona" }, { "city": "Concord", "state": "California" }, { "city": "Encinitas", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00859898" } ] }