{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+matching+Metformin", "query": { "intervention": "Placebo matching Metformin" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 141, "total_pages": 15, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+matching+Metformin&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-21T13:05:57.259Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00838903", "title": "Efficacy and Safety of Albiglutide in Treatment of Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "albiglutide", "type": "BIOLOGICAL" }, { "name": "sitagliptin", "type": "DRUG" }, { "name": "glimepiride", "type": "DRUG" }, { "name": "metformin", "type": "DRUG" }, { "name": "placebo albiglutide", "type": "BIOLOGICAL" }, { "name": "placebo sitagliptin", "type": "DRUG" }, { "name": "placebo glimepiride", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1049, "start_date": "2009-02", "completion_date": "2013-04", "has_results": true, "last_update_posted_date": "2017-01-09", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 317, "location_summary": "Birmingham, Alabama • Dothan, Alabama • Hueytown, Alabama + 254 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Dothan", "state": "Alabama" }, { "city": "Hueytown", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT00838903" }, { "nct_id": "NCT02045290", "title": "Insulin Clamp Ancillary Study for Assessment of Insulin Resistance", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 1 Diabetes" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Jaeb Center for Health Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "19 Years", "sex": "ALL", "summary": "12 Years to 19 Years" }, "enrollment_count": 37, "start_date": "2014-01", "completion_date": "2016-02-15", "has_results": false, "last_update_posted_date": "2017-03-14", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 1, "location_summary": "Tampa, Florida", "locations": [ { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02045290" }, { "nct_id": "NCT04510194", "title": "COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Covid19", "SARS-CoV Infection" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Fluvoxamine", "type": "DRUG" }, { "name": "Ivermectin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Minnesota", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "30 Years to 85 Years" }, "enrollment_count": 1323, "start_date": "2021-01-01", "completion_date": "2022-12-14", "has_results": true, "last_update_posted_date": "2026-04-24", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 7, "location_summary": "Sylmar, California • Aurora, Colorado • Golden, Colorado + 3 more", "locations": [ { "city": "Sylmar", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Golden", "state": "Colorado" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Greenfield", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04510194" }, { "nct_id": "NCT05132439", "title": "MetfOrmin BenefIts Lower Extremities With Intermittent Claudication", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Intermittent Claudication" ], "interventions": [ { "name": "Metformin ER", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": "89 Years", "sex": "ALL", "summary": "35 Years to 89 Years" }, "enrollment_count": 200, "start_date": "2022-03-01", "completion_date": "2032-02-28", "has_results": false, "last_update_posted_date": "2026-04-21", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05132439" }, { "nct_id": "NCT01881828", "title": "Metformin Therapy for Overweight Adolescents With Type 1 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 1 Diabetes" ], "interventions": [ { "name": "Metformin (glucophage)", "type": "DRUG" }, { "name": "oral placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Jaeb Center for Health Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "19 Years", "sex": "ALL", "summary": "12 Years to 19 Years" }, "enrollment_count": 164, "start_date": "2013-09", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2020-03-03", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 1, "location_summary": "Tampa, Florida", "locations": [ { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01881828" }, { "nct_id": "NCT02932475", "title": "Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes", "Pregnancy" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 831, "start_date": "2017-05-25", "completion_date": "2022-06-15", "has_results": true, "last_update_posted_date": "2023-06-26", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 10, "location_summary": "Birmingham, Alabama • San Diego, California • Jackson, Mississippi + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "San Diego", "state": "California" }, { "city": "Jackson", "state": "Mississippi" }, { "city": "New York", "state": "New York" }, { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02932475" }, { "nct_id": "NCT01106690", "title": "The CANTATA-MP Trial (CANagliflozin Treatment and Trial Analysis - Metformin and Pioglitazone)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Canagliflozin", "type": "DRUG" }, { "name": "Sitagliptin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 344, "start_date": "2010-06", "completion_date": "2012-07", "has_results": true, "last_update_posted_date": "2013-07-15", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 41, "location_summary": "Anniston, Alabama • Phoenix, Arizona • Tucson, Arizona + 38 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Burlingame", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01106690" }, { "nct_id": "NCT03429543", "title": "Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Insulin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Linagliptin", "type": "DRUG" }, { "name": "Empagliflozin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Boehringer Ingelheim", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "10 Years to 17 Years" }, "enrollment_count": 175, "start_date": "2018-03-20", "completion_date": "2023-05-31", "has_results": true, "last_update_posted_date": "2024-02-23", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 44, "location_summary": "Phoenix, Arizona • Tucson, Arizona • Orange, California + 39 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Orange", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03429543" }, { "nct_id": "NCT03351478", "title": "Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "Sotagliflozin", "type": "DRUG" }, { "name": "Empagliflozin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Lexicon Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 770, "start_date": "2017-11-27", "completion_date": "2019-05-16", "has_results": true, "last_update_posted_date": "2021-05-11", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 53, "location_summary": "Birmingham, Alabama • Sheffield, Alabama • Hawaiian Gardens, California + 40 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Sheffield", "state": "Alabama" }, { "city": "Hawaiian Gardens", "state": "California" }, { "city": "Spring Valley", "state": "California" }, { "city": "Van Nuys", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03351478" }, { "nct_id": "NCT03066830", "title": "Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "Sotagliflozin (SAR439954)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Sulfonylurea", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Lexicon Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 507, "start_date": "2017-02-24", "completion_date": "2019-04-30", "has_results": true, "last_update_posted_date": "2021-05-11", "last_synced_at": "2026-09-21T13:05:57.259Z", "location_count": 28, "location_summary": "Litchfield Park, Arizona • Peoria, Arizona • Greenbrae, California + 25 more", "locations": [ { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Greenbrae", "state": "California" }, { "city": "Huntington Park", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03066830" } ] }