{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+matching+Metformin&page=4", "query": { "intervention": "Placebo matching Metformin", "page": 4 }, "page_size": 10 }, "pagination": { "page": 4, "page_size": 10, "total_count": 142, "total_pages": 15, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+matching+Metformin&page=5&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+matching+Metformin&page=3&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-04T15:38:56.950Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01023581", "title": "Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Alogliptin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Alogliptin Placebo", "type": "DRUG" }, { "name": "Metformin Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 784, "start_date": "2009-11", "completion_date": "2011-06", "has_results": true, "last_update_posted_date": "2013-03-26", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 109, "location_summary": "Dothan, Alabama • Muscle Shoals, Alabama • Pell City, Alabama + 106 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Pell City", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01023581" }, { "nct_id": "NCT00816907", "title": "The Use of Metformin in the Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (The METS Study)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 146, "start_date": "2009-01", "completion_date": "2010-03", "has_results": true, "last_update_posted_date": "2013-03-27", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 16, "location_summary": "Palo Alto, California • Boca Raton, Florida • Iowa City, Iowa + 13 more", "locations": [ { "city": "Palo Alto", "state": "California" }, { "city": "Boca Raton", "state": "Florida" }, { "city": "Iowa City", "state": "Iowa" }, { "city": "Wichita", "state": "Kansas" }, { "city": "Glen Burnie", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00816907" }, { "nct_id": "NCT01298518", "title": "A Multiple Dose Study Of PF-04620110 In Type 2 Diabetes Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Type 2 Diabetes Patients" ], "interventions": [ { "name": "PF-04620110", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 48, "start_date": "2011-02", "completion_date": "2011-05", "has_results": true, "last_update_posted_date": "2012-11-06", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 3, "location_summary": "Chula Vista, California • DeLand, Florida • Miami Gardens, Florida", "locations": [ { "city": "Chula Vista", "state": "California" }, { "city": "DeLand", "state": "Florida" }, { "city": "Miami Gardens", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01298518" }, { "nct_id": "NCT01106690", "title": "The CANTATA-MP Trial (CANagliflozin Treatment and Trial Analysis - Metformin and Pioglitazone)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Canagliflozin", "type": "DRUG" }, { "name": "Sitagliptin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 344, "start_date": "2010-06", "completion_date": "2012-07", "has_results": true, "last_update_posted_date": "2013-07-15", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 41, "location_summary": "Anniston, Alabama • Phoenix, Arizona • Tucson, Arizona + 38 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Burlingame", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01106690" }, { "nct_id": "NCT02796144", "title": "MEtformin and Lorcaserin for WeighT Loss in Schizophrenia", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Schizophrenia", "Schizoaffective Disorder", "Overweight" ], "interventions": [ { "name": "Lorcaserin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 71, "start_date": "2016-09", "completion_date": "2020-02-14", "has_results": true, "last_update_posted_date": "2021-03-03", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 4, "location_summary": "Augusta, Georgia • New York, New York • Chapel Hill, North Carolina + 1 more", "locations": [ { "city": "Augusta", "state": "Georgia" }, { "city": "New York", "state": "New York" }, { "city": "Chapel Hill", "state": "North Carolina" }, { "city": "Hillsborough", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02796144" }, { "nct_id": "NCT00631007", "title": "A Placebo Controlled Safety and Efficacy Study of INT131 Besylate in Type 2 Diabetes, With an Active Comparator", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "INT131 besylate", "type": "DRUG" }, { "name": "Pioglitazone HCl", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "InteKrin Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "30 Years to 75 Years" }, "enrollment_count": 367, "start_date": "2008-02", "completion_date": "2009-09", "has_results": true, "last_update_posted_date": "2010-09-13", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 59, "location_summary": "Carmichael, California • Los Angeles, California • San Diego, California + 48 more", "locations": [ { "city": "Carmichael", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Ana", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT00631007" }, { "nct_id": "NCT03285594", "title": "Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "Sotagliflozin", "type": "DRUG" }, { "name": "Insulin glargine (HOE901)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Oral Antidiabetes Drugs (OADs)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Lexicon Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 571, "start_date": "2017-09-15", "completion_date": "2019-09-27", "has_results": true, "last_update_posted_date": "2021-05-11", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 50, "location_summary": "Mesa, Arizona • Phoenix, Arizona • Huntington Park, California + 42 more", "locations": [ { "city": "Mesa", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Huntington Park", "state": "California" }, { "city": "Lincoln", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03285594" }, { "nct_id": "NCT00838903", "title": "Efficacy and Safety of Albiglutide in Treatment of Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "albiglutide", "type": "BIOLOGICAL" }, { "name": "sitagliptin", "type": "DRUG" }, { "name": "glimepiride", "type": "DRUG" }, { "name": "metformin", "type": "DRUG" }, { "name": "placebo albiglutide", "type": "BIOLOGICAL" }, { "name": "placebo sitagliptin", "type": "DRUG" }, { "name": "placebo glimepiride", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1049, "start_date": "2009-02", "completion_date": "2013-04", "has_results": true, "last_update_posted_date": "2017-01-09", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 317, "location_summary": "Birmingham, Alabama • Dothan, Alabama • Hueytown, Alabama + 254 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Dothan", "state": "Alabama" }, { "city": "Hueytown", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT00838903" }, { "nct_id": "NCT05949008", "title": "Effect of Metformin, a Drug Used to Treat Diabetes, vs Placebo", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "NIDDM", "Obesity" ], "interventions": [ { "name": "Metformin Extended Release (ER) Oral Tablet", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 150, "start_date": "2023-11-22", "completion_date": "2028-07-30", "has_results": false, "last_update_posted_date": "2026-06-08", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05949008" }, { "nct_id": "NCT02430870", "title": "TAK-648 Multiple-Rising Dose Study in Healthy Japanese Participants and Non-Japanese Participants With Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "TAK-648", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 48, "start_date": "2015-04", "completion_date": "2015-11", "has_results": true, "last_update_posted_date": "2016-08-31", "last_synced_at": "2026-10-04T15:38:56.950Z", "location_count": 2, "location_summary": "Anaheim, California • Chula Vista, California", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Chula Vista", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02430870" } ] }