{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+of+Enalapril", "query": { "intervention": "Placebo of Enalapril" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 17, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+of+Enalapril&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-24T21:04:22.270Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00113087", "title": "Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heart Defects, Congenital", "Heart Failure, Congestive" ], "interventions": [ { "name": "Enalapril", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "45 Days", "sex": "ALL", "summary": "Up to 45 Days" }, "enrollment_count": 230, "start_date": "2003-08", "completion_date": "2008-07", "has_results": true, "last_update_posted_date": "2010-09-28", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 8, "location_summary": "Boston, Massachusetts • New York, New York • Durham, North Carolina + 5 more", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00113087" }, { "nct_id": "NCT00666848", "title": "Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Metabolic Syndrome", "Hypertension" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Enalapril 5mg", "type": "DRUG" }, { "name": "Enalapril 10mg", "type": "DRUG" }, { "name": "Sitagliptin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 24, "start_date": "2008-03", "completion_date": "2010-01", "has_results": true, "last_update_posted_date": "2012-05-11", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00666848" }, { "nct_id": "NCT01754909", "title": "Mitigation of Radiation Pneumonitis and Fibrosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Lung Cancer", "Radiation Pneumonitis" ], "interventions": [ { "name": "Enalapril", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "35 Years to 85 Years" }, "enrollment_count": 50, "start_date": "2013-11-01", "completion_date": "2018-04-01", "has_results": true, "last_update_posted_date": "2019-10-08", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 3, "location_summary": "Baltimore, Maryland • Ann Arbor, Michigan • Milwaukee, Wisconsin", "locations": [ { "city": "Baltimore", "state": "Maryland" }, { "city": "Ann Arbor", "state": "Michigan" }, { "city": "Milwaukee", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT01754909" }, { "nct_id": "NCT02874794", "title": "Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Heart Failure and Reduced Ejection Fraction" ], "interventions": [ { "name": "LCZ696 (sacubitril/valsartan)", "type": "DRUG" }, { "name": "Enalapril", "type": "DRUG" }, { "name": "Placebo of Enalapril", "type": "DRUG" }, { "name": "Placebo of LCZ696", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 465, "start_date": "2016-08-17", "completion_date": "2019-01-26", "has_results": true, "last_update_posted_date": "2021-01-05", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 81, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Beverly Hills, California + 69 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Huntington Beach", "state": "California" }, { "city": "Newport Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02874794" }, { "nct_id": "NCT03066804", "title": "A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heart Failure With Preserved Ejection Fraction" ], "interventions": [ { "name": "sacubitril/valsartan", "type": "DRUG" }, { "name": "Enalapril", "type": "DRUG" }, { "name": "Valsartan", "type": "DRUG" }, { "name": "Placebo to match sacubitril/valsartan", "type": "DRUG" }, { "name": "Placebo to match enalapril", "type": "DRUG" }, { "name": "Placebo to match valsartan", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "45 Years", "maximum_age": null, "sex": "ALL", "summary": "45 Years and older" }, "enrollment_count": 2572, "start_date": "2017-08-22", "completion_date": "2019-10-28", "has_results": true, "last_update_posted_date": "2021-10-11", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 32, "location_summary": "Andalusia, Alabama • Mobile, Alabama • Beverly Hills, California + 29 more", "locations": [ { "city": "Andalusia", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Santa Ana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03066804" }, { "nct_id": "NCT03005184", "title": "Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Heart Failure NYHA Class I", "Heart Failure NYHA Class II", "Heart Failure NYHA Class III" ], "interventions": [ { "name": "Valsartan 80 mg bid", "type": "DRUG" }, { "name": "Enalapril 10 mg bid", "type": "DRUG" }, { "name": "Sacubitril-Valsartan 200 mg bid", "type": "DRUG" }, { "name": "Icatibant", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 0, "start_date": "2017-09", "completion_date": "2020-01", "has_results": false, "last_update_posted_date": "2018-01-11", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03005184" }, { "nct_id": "NCT02554890", "title": "Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Acute Heart Failure" ], "interventions": [ { "name": "sacubitril/valsartan (LCZ696)", "type": "DRUG" }, { "name": "Enalapril", "type": "DRUG" }, { "name": "sacubitril/valsartan (LCZ696) matching placebo", "type": "DRUG" }, { "name": "enalapril matching placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 887, "start_date": "2016-04-29", "completion_date": "2018-07-24", "has_results": true, "last_update_posted_date": "2021-01-05", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 123, "location_summary": "Birmingham, Alabama • Fort Smith, Arkansas • Little Rock, Arkansas + 105 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Fort Smith", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bakersfield", "state": "California" }, { "city": "Fresno", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02554890" }, { "nct_id": "NCT01117038", "title": "Drug Interaction Study of Avanafil and Enalapril or Amlodipine", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Erectile Dysfunction" ], "interventions": [ { "name": "avanafil and enalapril", "type": "DRUG" }, { "name": "avanafil and amlodipine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VIVUS LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "40 Years", "maximum_age": "65 Years", "sex": "MALE", "summary": "40 Years to 65 Years · Male only" }, "enrollment_count": 48, "start_date": "2010-04", "completion_date": "2010-05", "has_results": false, "last_update_posted_date": "2011-08-10", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 1, "location_summary": "Tempe, Arizona", "locations": [ { "city": "Tempe", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01117038" }, { "nct_id": "NCT00446511", "title": "Extension Study to Assess Long Term Safety, Tolerability, and Efficacy of Valsartan and Enalapril Combined and Alone in Children With Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Valsartan", "type": "DRUG" }, { "name": "Enalapril", "type": "DRUG" }, { "name": "placebo matched to enalapril", "type": "DRUG" }, { "name": "placebo matched to valsartan", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "6 Years to 17 Years" }, "enrollment_count": 250, "start_date": "2007-06", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2011-07-12", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 1, "location_summary": "East Hanover, New Jersey", "locations": [ { "city": "East Hanover", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00446511" }, { "nct_id": "NCT00113698", "title": "Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heart Defects, Congenital", "Heart Septal Defects, Ventricular", "Heart Failure, Congestive" ], "interventions": [ { "name": "Enalapril", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of Utah", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "18 Years", "sex": "ALL", "summary": "Up to 18 Years" }, "enrollment_count": 5, "start_date": "2004-12", "completion_date": "2006-01", "has_results": false, "last_update_posted_date": "2014-03-13", "last_synced_at": "2026-09-24T21:04:22.270Z", "location_count": 6, "location_summary": "Boston, Massachusetts • New York, New York • Durham, North Carolina + 3 more", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Charleston", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00113698" } ] }