{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+to+Methotrexate&page=3", "query": { "intervention": "Placebo to Methotrexate", "page": 3 }, "page_size": 10 }, "pagination": { "page": 3, "page_size": 10, "total_count": 186, "total_pages": 19, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+to+Methotrexate&page=4&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+to+Methotrexate&page=2&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-04T22:06:47.332Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01359943", "title": "Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "secukinumab (AIN457)", "type": "BIOLOGICAL" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 221, "start_date": "2011-10", "completion_date": "2013-12", "has_results": true, "last_update_posted_date": "2015-03-02", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 8, "location_summary": "Vestavia Hills, Alabama • Peoria, Arizona • Upland, California + 5 more", "locations": [ { "city": "Vestavia Hills", "state": "Alabama" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Upland", "state": "California" }, { "city": "Bowling Green", "state": "Kentucky" }, { "city": "Tupelo", "state": "Mississippi" } ], "official_url": "https://clinicaltrials.gov/study/NCT01359943" }, { "nct_id": "NCT01773395", "title": "GVAX vs. Placebo for MDS/AML After Allo HSCT", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Myelodysplastic Syndrome", "Acute Myeloid Leukemia", "Chronic Myelomonocytic Leukemia" ], "interventions": [ { "name": "GVAX", "type": "BIOLOGICAL" }, { "name": "Placebo Vaccine", "type": "BIOLOGICAL" }, { "name": "Allogeneic Hematopoietic Stem Cell Transplant", "type": "PROCEDURE" }, { "name": "Busulfan", "type": "DRUG" }, { "name": "Fludarabine", "type": "DRUG" }, { "name": "Tacrolimus", "type": "DRUG" }, { "name": "Methotrexate", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "PROCEDURE", "DRUG" ], "sponsor": "Dana-Farber Cancer Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 123, "start_date": "2013-01-08", "completion_date": "2021-11-24", "has_results": true, "last_update_posted_date": "2022-07-18", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 4, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01773395" }, { "nct_id": "NCT01999192", "title": "Study to Investigate the Safety and Efficacy of Tregalizumab in Subjects (MTX-IR) With Active Rheumatoid Arthritis", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Tregalizumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Biotest", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 321, "start_date": "2013-10", "completion_date": "2015-07", "has_results": true, "last_update_posted_date": "2017-08-24", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 8, "location_summary": "Paradise Valley, Arizona • Springfield, Illinois • Lincoln, Nebraska + 5 more", "locations": [ { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Springfield", "state": "Illinois" }, { "city": "Lincoln", "state": "Nebraska" }, { "city": "Clifton", "state": "New Jersey" }, { "city": "North Charleston", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01999192" }, { "nct_id": "NCT01009242", "title": "To Evaluate the Blood Levels and Safety of IV and Subcutaneous CDP6038 in Subjects With Rheumatoid Arthritis Using Methotrexate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Arthritis", "Rheumatoid Arthritis" ], "interventions": [ { "name": "CDP6038", "type": "BIOLOGICAL" }, { "name": "Placebo IV", "type": "OTHER" }, { "name": "Placebo SC", "type": "OTHER" }, { "name": "CDP 6038 SC", "type": "DRUG" }, { "name": "Methotrexate", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "OTHER", "DRUG" ], "sponsor": "UCB Pharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 40, "start_date": "2009-10", "completion_date": "2010-09", "has_results": false, "last_update_posted_date": "2024-11-15", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 3, "location_summary": "Duncansville, Pennsylvania • Dallas, Texas • San Antonio, Texas", "locations": [ { "city": "Duncansville", "state": "Pennsylvania" }, { "city": "Dallas", "state": "Texas" }, { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01009242" }, { "nct_id": "NCT00105976", "title": "Efficacy Study of MM-093 in Rheumatoid Arthritis Patients on Methotrexate (MTX)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "MM-093", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merrimack Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 260, "start_date": "2005-02", "completion_date": null, "has_results": false, "last_update_posted_date": "2008-07-11", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 38, "location_summary": "Birmingham, Alabama • Montgomery, Alabama • Paradise Valley, Arizona + 33 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Montgomery", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00105976" }, { "nct_id": "NCT00316771", "title": "A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "P38 Inhibitor (4) 150mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 25mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 300mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 50mg", "type": "DRUG" }, { "name": "P38 Inhibitor (4) 75mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 374, "start_date": "2005-11", "completion_date": "2008-03", "has_results": false, "last_update_posted_date": "2016-11-02", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 48, "location_summary": "Birmingham, Alabama • Paradise Valley, Arizona • Tucson, Arizona + 42 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00316771" }, { "nct_id": "NCT00976599", "title": "A Study To Evaluate The Mechanism Of Action Of CP-690,550 In Patients With Rheumatoid Arthritis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "CP-690,550 + methotrexate", "type": "DRUG" }, { "name": "Placebo + Methotrexate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 29, "start_date": "2009-11", "completion_date": "2011-07", "has_results": true, "last_update_posted_date": "2013-01-09", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 15, "location_summary": "Birmingham, Alabama • La Jolla, California • Frederick, Maryland + 8 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "La Jolla", "state": "California" }, { "city": "Frederick", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00976599" }, { "nct_id": "NCT01198002", "title": "A Rheumatoid Arthritis Study in Participants on a Background Treatment of Methotrexate", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "LY2127399", "type": "DRUG" }, { "name": "Placebo Q2W", "type": "DRUG" }, { "name": "Placebo Q4W", "type": "DRUG" }, { "name": "Methotrexate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eli Lilly and Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1041, "start_date": "2010-12", "completion_date": "2014-01", "has_results": true, "last_update_posted_date": "2018-05-08", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 75, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Paradise Valley, Arizona + 72 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01198002" }, { "nct_id": "NCT00406419", "title": "A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate Treatment (STAGE)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Methotrexate", "type": "DRUG" }, { "name": "ocrelizumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Genentech, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1015, "start_date": "2006-12-27", "completion_date": "2015-04-22", "has_results": true, "last_update_posted_date": "2020-11-27", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 1, "location_summary": "South San Francisco, California", "locations": [ { "city": "South San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00406419" }, { "nct_id": "NCT00718718", "title": "A Study of Effectiveness and Safety of CNTO 136 in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Arthritis, Rheumatoid" ], "interventions": [ { "name": "CNTO 136 100 mg", "type": "DRUG" }, { "name": "CNTO 136 50 mg", "type": "DRUG" }, { "name": "CNTO 136 25 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Methotrexate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Centocor, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 187, "start_date": "2008-08-11", "completion_date": "2011-03-03", "has_results": true, "last_update_posted_date": "2018-01-23", "last_synced_at": "2026-10-04T22:06:47.332Z", "location_count": 8, "location_summary": "Aventura, Florida • Lexington, Kentucky • Frederick, Maryland + 5 more", "locations": [ { "city": "Aventura", "state": "Florida" }, { "city": "Lexington", "state": "Kentucky" }, { "city": "Frederick", "state": "Maryland" }, { "city": "Kalamazoo", "state": "Michigan" }, { "city": "Charlotte", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00718718" } ] }