{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+to+Nexium", "query": { "intervention": "Placebo to Nexium" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 15, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+to+Nexium&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-23T01:14:41.991Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02637557", "title": "A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Gastroesophageal Reflux Disease" ], "interventions": [ { "name": "IW-3718", "type": "DRUG" }, { "name": "Matching Placebo", "type": "DRUG" }, { "name": "PPI", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ironwood Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 282, "start_date": "2016-03-01", "completion_date": "2017-04-26", "has_results": true, "last_update_posted_date": "2019-10-15", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 62, "location_summary": "Dothan, Alabama • Phoenix, Arizona • Tucson, Arizona + 54 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT02637557" }, { "nct_id": "NCT01216293", "title": "Effect of Dexlansoprazole on Bone Homeostasis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Homeostasis", "Bone and Bones" ], "interventions": [ { "name": "Dexlansoprazole", "type": "DRUG" }, { "name": "Esomeprazole", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": null, "maximum_age": "75 Years", "sex": "FEMALE", "summary": "Up to 75 Years · Female only" }, "enrollment_count": 115, "start_date": "2010-11-01", "completion_date": "2015-02-01", "has_results": true, "last_update_posted_date": "2024-03-18", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 12, "location_summary": "San Diego, California • Walnut Creek, California • Lakewood, Colorado + 9 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Lakewood", "state": "Colorado" }, { "city": "Hialeah", "state": "Florida" }, { "city": "Jupiter", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01216293" }, { "nct_id": "NCT00361985", "title": "Study of Proton Pump Inhibitors (PPI) to Prevent Strictures After Gastric Bypass Surgery", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Anastomotic Stricture", "Morbid Obesity" ], "interventions": [ { "name": "Esomeprazole", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Weill Medical College of Cornell University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 0, "start_date": "2008-01", "completion_date": "2011-07", "has_results": false, "last_update_posted_date": "2016-11-01", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00361985" }, { "nct_id": "NCT02708355", "title": "Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Heartburn" ], "interventions": [ { "name": "Esomeprazole 20 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "22 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "22 Years to 65 Years" }, "enrollment_count": 55, "start_date": "2016-01", "completion_date": "2016-04", "has_results": true, "last_update_posted_date": "2017-04-19", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 2, "location_summary": "Oklahoma City, Oklahoma", "locations": [ { "city": "Oklahoma City", "state": "Oklahoma" }, { "city": "Oklahoma City", "state": "Oklahoma" } ], "official_url": "https://clinicaltrials.gov/study/NCT02708355" }, { "nct_id": "NCT00444236", "title": "Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Exercise Triggered Asthma", "Gastroesophageal Reflux" ], "interventions": [ { "name": "Nexium", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Utah", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 31, "start_date": "2007-04", "completion_date": "2009-09", "has_results": false, "last_update_posted_date": "2016-01-21", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT00444236" }, { "nct_id": "NCT00978016", "title": "A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Gastroesophageal Reflux Disease" ], "interventions": [ { "name": "arbaclofen placarbil-Cohort 1", "type": "DRUG" }, { "name": "Placebo-Cohort 5", "type": "DRUG" }, { "name": "arbaclofen placarbil-Cohort 2", "type": "DRUG" }, { "name": "arbaclofen placarbil-Cohort 3", "type": "DRUG" }, { "name": "arbaclofen placarbil-Cohort 4", "type": "DRUG" }, { "name": "PPI", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "XenoPort, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 460, "start_date": "2009-09", "completion_date": "2010-12", "has_results": false, "last_update_posted_date": "2021-02-21", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 62, "location_summary": "Huntsville, Alabama • Chandler, Arizona • Mesa, Arizona + 56 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00978016" }, { "nct_id": "NCT01142128", "title": "Viokase 16, Viokase16 Plus Nexium and Nexium Alone", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Chronic Pancreatitis" ], "interventions": [ { "name": "Nexium (esomeprazole magnesium)", "type": "DRUG" }, { "name": "Placebo to Nexium", "type": "DRUG" }, { "name": "Viokase 16 (pancrelipase) + Nexium", "type": "DRUG" }, { "name": "Viokase 16 + placebo to Nexium", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 12, "start_date": "2009-02", "completion_date": "2012-03", "has_results": true, "last_update_posted_date": "2013-02-21", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01142128" }, { "nct_id": "NCT03488147", "title": "Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Dysphagia", "GERD", "Degenerative Joint Disease" ], "interventions": [ { "name": "Esomeprazole", "type": "DRUG" }, { "name": "Placebo Oral Tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2020-07", "completion_date": "2020-07-02", "has_results": false, "last_update_posted_date": "2020-11-23", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 2, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03488147" }, { "nct_id": "NCT00660660", "title": "Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Gastroesophageal Reflux Disease" ], "interventions": [ { "name": "Esomeprazole", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 276, "start_date": "2008-04", "completion_date": "2008-07", "has_results": true, "last_update_posted_date": "2015-03-02", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 45, "location_summary": "Huntsville, Alabama • Tucson, Arizona • Little Rock, Arkansas + 42 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Burbank", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00660660" }, { "nct_id": "NCT01983774", "title": "Effect of Proton Pump Inhibitors on CF Pulmonary Exacerbations", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "Esomeprazole", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Columbia University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 21, "start_date": "2008-02", "completion_date": "2011-08", "has_results": true, "last_update_posted_date": "2022-02-17", "last_synced_at": "2026-09-23T01:14:41.991Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01983774" } ] }