{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+toothpaste",
    "query": {
      "intervention": "Placebo toothpaste"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 35,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Placebo+toothpaste&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-08T21:46:51.524Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01657903",
      "title": "Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Erosion",
        "Acid Wear"
      ],
      "interventions": [
        {
          "name": "Sodium Fluoride",
          "type": "DRUG"
        },
        {
          "name": "Potassium nitrate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 56,
      "start_date": "2011-11",
      "completion_date": "2012-02",
      "has_results": true,
      "last_update_posted_date": "2015-01-26",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01657903"
    },
    {
      "nct_id": "NCT04603300",
      "title": "OMEGA Study: A Study of the Safety and Feasibility of Up-titration With INT301 in Adults With Sensitivity to Peanut",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Peanut Allergy"
      ],
      "interventions": [
        {
          "name": "INT301",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Intrommune Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 32,
      "start_date": "2021-05-15",
      "completion_date": "2023-06-30",
      "has_results": false,
      "last_update_posted_date": "2023-07-28",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 2,
      "location_summary": "Belleville, New Jersey • Riverdale, New Jersey",
      "locations": [
        {
          "city": "Belleville",
          "state": "New Jersey"
        },
        {
          "city": "Riverdale",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04603300"
    },
    {
      "nct_id": "NCT01176396",
      "title": "CAMBRA - PBRN Caries Management By Risk Assessment In A Practice-Based Research Network",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Caries prevention active intervention",
          "type": "OTHER"
        },
        {
          "name": "control treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "12 Years to 65 Years"
      },
      "enrollment_count": 460,
      "start_date": "2012-04",
      "completion_date": "2017-05",
      "has_results": false,
      "last_update_posted_date": "2020-04-10",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01176396"
    },
    {
      "nct_id": "NCT01881074",
      "title": "Periodontal Treatment Response in Type II Diabetic Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Type II Diabetes",
        "Periodontal Disease"
      ],
      "interventions": [
        {
          "name": "Triclosan containing toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Non-triclosan containing toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 74,
      "start_date": "2012-06",
      "completion_date": "2015-12",
      "has_results": false,
      "last_update_posted_date": "2018-09-17",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01881074"
    },
    {
      "nct_id": "NCT02589938",
      "title": "Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Radiation-Induced Xerostomia",
        "Head and Neck Cancer",
        "Radiation Toxicity",
        "Oral Complications of Chemotherapy and Head/Neck Radiation"
      ],
      "interventions": [
        {
          "name": "Standard Oral Hygiene",
          "type": "OTHER"
        },
        {
          "name": "Standard Oral Hygiene + True Acupuncture",
          "type": "OTHER"
        },
        {
          "name": "Standard Oral Hygiene + Sham Acupuncture",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 258,
      "start_date": "2012-11-11",
      "completion_date": "2022-07-29",
      "has_results": true,
      "last_update_posted_date": "2026-02-27",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 36,
      "location_summary": "Burbank, California • San Francisco, California • San Jose, California + 26 more",
      "locations": [
        {
          "city": "Burbank",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "San Rafael",
          "state": "California"
        },
        {
          "city": "San Rafael",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02589938"
    },
    {
      "nct_id": "NCT03154021",
      "title": "Next Science Antimicrobial Mouth Rinse Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Gingivitis",
        "Dental Plaque"
      ],
      "interventions": [
        {
          "name": "Next Science OTC Oral Rinse with Essential Oils",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "OTC Oral Rinse Control",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 118,
      "start_date": "2017-08-28",
      "completion_date": "2018-05-15",
      "has_results": false,
      "last_update_posted_date": "2019-02-18",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 2,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03154021"
    },
    {
      "nct_id": "NCT01224158",
      "title": "Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Devices, Home Care"
      ],
      "interventions": [
        {
          "name": "Experimental Power Toothbrush",
          "type": "DEVICE"
        },
        {
          "name": "Flat trimmed Manual Toothbrush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 153,
      "start_date": "2010-09-13",
      "completion_date": "2010-10-29",
      "has_results": true,
      "last_update_posted_date": "2019-12-04",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 1,
      "location_summary": "Las Vegas, Nevada",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01224158"
    },
    {
      "nct_id": "NCT03296072",
      "title": "In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Tooth Erosion"
      ],
      "interventions": [
        {
          "name": "0.254% w/w sodium fluoride and 5% KNO3",
          "type": "DRUG"
        },
        {
          "name": "0.454% w/w stannous fluoride",
          "type": "DRUG"
        },
        {
          "name": "5% KNO3",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 62,
      "start_date": "2017-11-13",
      "completion_date": "2018-01-16",
      "has_results": true,
      "last_update_posted_date": "2020-09-16",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03296072"
    },
    {
      "nct_id": "NCT01128972",
      "title": "Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tooth Erosion"
      ],
      "interventions": [
        {
          "name": "Sodium fluoride",
          "type": "DRUG"
        },
        {
          "name": "Sodium monoflurophosphate",
          "type": "DRUG"
        },
        {
          "name": "Sterile water",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 36,
      "start_date": "2009-08",
      "completion_date": "2009-10",
      "has_results": true,
      "last_update_posted_date": "2015-01-01",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01128972"
    },
    {
      "nct_id": "NCT03383783",
      "title": "Evaluation of the Fluoride Dose Response of a Modified In Situ Caries Model",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Caries"
      ],
      "interventions": [
        {
          "name": "0 ppm F (placebo, negative control)",
          "type": "DRUG"
        },
        {
          "name": "250 ppm F as NaF (dose-response control)",
          "type": "DRUG"
        },
        {
          "name": "500 ppm F as NaF (dose-response control)",
          "type": "DRUG"
        },
        {
          "name": "1100 ppm F as NaF (positive control)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Domenick Zero",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 28,
      "start_date": "2017-12-19",
      "completion_date": "2018-05-02",
      "has_results": true,
      "last_update_posted_date": "2019-05-20",
      "last_synced_at": "2026-09-08T21:46:51.524Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03383783"
    }
  ]
}