{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Positive+End-Expiratory+Pressure+%28PEEP%29",
    "query": {
      "intervention": "Positive End-Expiratory Pressure (PEEP)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 63,
    "total_pages": 7,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Positive+End-Expiratory+Pressure+%28PEEP%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-30T09:26:18.698Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01471431",
      "title": "Extubation Readiness Study in Very Low Birthweight Infants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "spontaneous breathing trial",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "48 Hours",
        "maximum_age": "14 Weeks",
        "sex": "ALL",
        "summary": "48 Hours to 14 Weeks"
      },
      "enrollment_count": 81,
      "start_date": "2011-08",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2016-06-07",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 2,
      "location_summary": "Phialdelphia, Pennsylvania • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Phialdelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01471431"
    },
    {
      "nct_id": "NCT05977153",
      "title": "CT for Personalized Mechanical Ventilation",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ventilator-Induced Lung Injury",
        "Sepsis Syndrome",
        "Mechanical Ventilation Complication"
      ],
      "interventions": [
        {
          "name": "PEEP (positive end-expiratory pressure) - maximum",
          "type": "PROCEDURE"
        },
        {
          "name": "PEEP (positive end-expiratory pressure) - standard",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 7,
      "start_date": "2023-05-10",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-09-26",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05977153"
    },
    {
      "nct_id": "NCT02139800",
      "title": "Sustained Aeration of Infant Lungs Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Birth",
        "Extreme Prematurity"
      ],
      "interventions": [
        {
          "name": "Sustained Inflation",
          "type": "PROCEDURE"
        },
        {
          "name": "Standard of Care",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "23 Weeks",
        "maximum_age": "26 Weeks",
        "sex": "ALL",
        "summary": "23 Weeks to 26 Weeks"
      },
      "enrollment_count": 460,
      "start_date": "2014-08-27",
      "completion_date": "2020-03-23",
      "has_results": true,
      "last_update_posted_date": "2023-04-06",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 9,
      "location_summary": "Loma Linda, California • Sacramento, California • San Diego, California + 5 more",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02139800"
    },
    {
      "nct_id": "NCT06572033",
      "title": "Transference of Established Simulated Skills (TEST) Trial",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neonatal Respiratory Distress"
      ],
      "interventions": [
        {
          "name": "Simulation",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 120,
      "start_date": "2024-08-12",
      "completion_date": "2026-06-29",
      "has_results": false,
      "last_update_posted_date": "2026-03-25",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06572033"
    },
    {
      "nct_id": "NCT06849596",
      "title": "Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Resuscitation",
        "Apnea Neonatal"
      ],
      "interventions": [
        {
          "name": "Ventilator derived positive pressure ventilation - V-PPV",
          "type": "DEVICE"
        },
        {
          "name": "T-piece resuscitator (TPR)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Michelle Baczynski",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Weeks",
        "maximum_age": "29 Weeks",
        "sex": "ALL",
        "summary": "25 Weeks to 29 Weeks"
      },
      "enrollment_count": 780,
      "start_date": "2025-12-01",
      "completion_date": "2029-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-11",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06849596"
    },
    {
      "nct_id": "NCT07774065",
      "title": "Mechanical Ventilation in Obese Surgical Patients",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obese"
      ],
      "interventions": [
        {
          "name": "Standard PEEP (8 cmH₂O)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "The University of Texas Medical Branch, Galveston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2026-07-29",
      "completion_date": "2027-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "Galveston, Texas",
      "locations": [
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07774065"
    },
    {
      "nct_id": "NCT02503241",
      "title": "Open Lung Strategy in Critically Ill Morbid Obese Patients",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Respiratory Insufficiency",
        "Right-Sided Heart Failure",
        "Pulmonary Atelectasis",
        "Respiratory Mechanics"
      ],
      "interventions": [
        {
          "name": "PEEP INCREMENTAL",
          "type": "PROCEDURE"
        },
        {
          "name": "PEEP DECREMENTAL",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2016-04",
      "completion_date": "2022-06-30",
      "has_results": false,
      "last_update_posted_date": "2020-11-17",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02503241"
    },
    {
      "nct_id": "NCT01901354",
      "title": "Acute Lung Injury Ventilator Evaluation (ALIVE)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Lung Injury",
        "Adult Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Low-tidal-volume ventilation",
          "type": "OTHER"
        },
        {
          "name": "Airway Pressure Release Ventilation (APRV)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2013-11",
      "completion_date": "2014-10",
      "has_results": false,
      "last_update_posted_date": "2017-09-28",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01901354"
    },
    {
      "nct_id": "NCT00431158",
      "title": "ARDSnet Protocol vs. Open Lung Approach in ARDS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Distress Syndrome, Adult"
      ],
      "interventions": [
        {
          "name": "Different Mechanical Ventilation Protocols",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 224,
      "start_date": "2007-01",
      "completion_date": "2013-03",
      "has_results": false,
      "last_update_posted_date": "2014-09-18",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00431158"
    },
    {
      "nct_id": "NCT02323009",
      "title": "Esophageal Balloon Guided Weaning of the Morbidly Obese Patient",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Morbid Obesity"
      ],
      "interventions": [
        {
          "name": "Esophageal Balloon",
          "type": "DEVICE"
        },
        {
          "name": "Cstat",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "East Carolina University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2011-01",
      "completion_date": "2013-11",
      "has_results": false,
      "last_update_posted_date": "2014-12-23",
      "last_synced_at": "2026-09-30T09:26:18.698Z",
      "location_count": 1,
      "location_summary": "Greenville, North Carolina",
      "locations": [
        {
          "city": "Greenville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02323009"
    }
  ]
}