{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Postoperative+methadone&page=2", "query": { "intervention": "Postoperative methadone", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Postoperative+methadone&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-26T03:37:50.115Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03908944", "title": "Postoperative Pain and Headache After Craniotomy", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "Methadone", "type": "DRUG" }, { "name": "Standard of Care", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Steven Edelstein", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 0, "start_date": "2019-01-02", "completion_date": "2022-01-02", "has_results": false, "last_update_posted_date": "2020-06-12", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Maywood, Illinois", "locations": [ { "city": "Maywood", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03908944" }, { "nct_id": "NCT07565870", "title": "Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Postoperative Pain", "Recovery" ], "interventions": [ { "name": "Intravenous Methadone", "type": "DRUG" }, { "name": "Short-acting Opioids Intraoperative analgesia", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alexandre P. Joosten", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 400, "start_date": "2026-07-01", "completion_date": "2027-03-30", "has_results": false, "last_update_posted_date": "2026-05-04", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Irvine, California", "locations": [ { "city": "Irvine", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07565870" }, { "nct_id": "NCT02091297", "title": "Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Caesarean Delivery" ], "interventions": [ { "name": "TAP Block", "type": "DRUG" }, { "name": "Ropivacaine", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Morphine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Dartmouth-Hitchcock Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 0, "start_date": "2014-04", "completion_date": "2014-04", "has_results": false, "last_update_posted_date": "2016-08-05", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 3, "location_summary": "Boston, Massachusetts • Lebanon, New Hampshire", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Lebanon", "state": "New Hampshire" } ], "official_url": "https://clinicaltrials.gov/study/NCT02091297" }, { "nct_id": "NCT02625181", "title": "Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Postoperative Nausea and Vomiting" ], "interventions": [ { "name": "Automated recommendation at the start of the case", "type": "PROCEDURE" }, { "name": "Automated notification at the start of surgery", "type": "PROCEDURE" }, { "name": "Preoperative recommendations: by email", "type": "PROCEDURE" }, { "name": "Automated notification at the end of surgery", "type": "PROCEDURE" }, { "name": "Anesthesia Information Management System (AIMS)", "type": "DEVICE" }, { "name": "Perioperative Data Warehouse (PDW)", "type": "DEVICE" }, { "name": "General anesthesia", "type": "PROCEDURE" }, { "name": "Elective surgery", "type": "PROCEDURE" }, { "name": "Propofol", "type": "DRUG" }, { "name": "Sevoflurane", "type": "DRUG" }, { "name": "Isoflurane", "type": "DRUG" }, { "name": "Desflurane", "type": "DRUG" }, { "name": "Scopolamine", "type": "DRUG" }, { "name": "Droperidol", "type": "DRUG" }, { "name": "Haloperidol", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Promethazine", "type": "DRUG" }, { "name": "Meclizine", "type": "DRUG" }, { "name": "Aprepitant", "type": "DRUG" }, { "name": "Metoclopramide", "type": "DRUG" }, { "name": "Fentanyl", "type": "DRUG" }, { "name": "Sufentanil", "type": "DRUG" }, { "name": "Alfentanil", "type": "DRUG" }, { "name": "Remifentanil", "type": "DRUG" }, { "name": "Morphine", "type": "DRUG" }, { "name": "Meperidine", "type": "DRUG" }, { "name": "Hydromorphone", "type": "DRUG" }, { "name": "Methadone", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" }, { "name": "Oxymorphone", "type": "DRUG" }, { "name": "Hydrocodone", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Ondansetron", "type": "DRUG" }, { "name": "Granisetron", "type": "DRUG" }, { "name": "Dolasetron mesylate", "type": "DRUG" }, { "name": "Palonosetron", "type": "DRUG" }, { "name": "Tropisetron", "type": "DRUG" }, { "name": "Ramosetron", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DEVICE", "DRUG" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 27034, "start_date": "2016-07", "completion_date": "2017-11-30", "has_results": true, "last_update_posted_date": "2019-03-07", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT02625181" }, { "nct_id": "NCT04525898", "title": "Intraoperative Methadone for Postoperative Pain Control After Thoracic Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "Methadone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Endeavor Health", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 40, "start_date": "2019-10-09", "completion_date": "2021-02-01", "has_results": false, "last_update_posted_date": "2021-12-21", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Evanston, Illinois", "locations": [ { "city": "Evanston", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04525898" }, { "nct_id": "NCT06691633", "title": "Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Osteoarthritis (OA) of the Knee" ], "interventions": [ { "name": "Preoperative Methadone", "type": "DRUG" }, { "name": "Preoperative Oxycodone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Louisville", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "89 Years", "sex": "ALL", "summary": "21 Years to 89 Years" }, "enrollment_count": 150, "start_date": "2024-02-19", "completion_date": "2024-10-18", "has_results": false, "last_update_posted_date": "2024-11-15", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Louisville, Kentucky", "locations": [ { "city": "Louisville", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT06691633" }, { "nct_id": "NCT02558010", "title": "Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Scoliosis", "Pain" ], "interventions": [ { "name": "Methadone", "type": "DRUG" }, { "name": "Normal Saline", "type": "OTHER" }, { "name": "Morphine", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Medical College of Wisconsin", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "18 Years", "sex": "ALL", "summary": "10 Years to 18 Years" }, "enrollment_count": 58, "start_date": "2016-02-01", "completion_date": "2023-01-01", "has_results": true, "last_update_posted_date": "2023-11-18", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Milwaukee, Wisconsin", "locations": [ { "city": "Milwaukee", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT02558010" }, { "nct_id": "NCT03605901", "title": "Dosing of Methadone for Spine Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Pain, Postoperative" ], "interventions": [ { "name": "Standard dosing of methadone", "type": "DRUG" }, { "name": "Aliquots of methadone titrated to apnea", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 21, "start_date": "2019-03-19", "completion_date": "2025-05-09", "has_results": true, "last_update_posted_date": "2026-06-23", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03605901" }, { "nct_id": "NCT05367609", "title": "Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "PPAP", "Spine Fusion" ], "interventions": [ { "name": "Preoperative Genotyping", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "Senthil Sadhasivam", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "21 Years", "sex": "ALL", "summary": "10 Years to 21 Years" }, "enrollment_count": 300, "start_date": "2022-09-20", "completion_date": "2027-10-30", "has_results": false, "last_update_posted_date": "2026-09-10", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 5, "location_summary": "San Francisco, California • St. Petersburg, Florida • Indianapolis, Indiana + 1 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "St. Petersburg", "state": "Florida" }, { "city": "St. Petersburg", "state": "Florida" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05367609" }, { "nct_id": "NCT02827526", "title": "Methadone and Ketamine for Spinal Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pain" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Control", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Endeavor Health", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 130, "start_date": "2016-07", "completion_date": "2021-02", "has_results": false, "last_update_posted_date": "2021-12-21", "last_synced_at": "2026-09-26T03:37:50.115Z", "location_count": 1, "location_summary": "Evanston, Illinois", "locations": [ { "city": "Evanston", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02827526" } ] }