{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Probiotics+%28BB-12%29",
    "query": {
      "intervention": "Probiotics (BB-12)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 23,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Probiotics+%28BB-12%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-28T11:22:18.942Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03514784",
      "title": "Combination Probiotic: BB-12 With LGG (Different Doses) in Treating Children With Autism Spectrum Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Autism Spectrum Disorder",
        "Gastrointestinal Symptoms"
      ],
      "interventions": [
        {
          "name": "BB-12 with LGG (Higher Dose)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "BB-12 with LGG (Lower Dose)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "16 Years",
        "sex": "ALL",
        "summary": "4 Years to 16 Years"
      },
      "enrollment_count": 100,
      "start_date": "2016-05",
      "completion_date": "2025-07-30",
      "has_results": true,
      "last_update_posted_date": "2026-09-14",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03514784"
    },
    {
      "nct_id": "NCT01731171",
      "title": "Probiotics to Prevent Relapse After Hospitalization for Mania",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bipolar Disorder",
        "Schizoaffective Disorder"
      ],
      "interventions": [
        {
          "name": "Probiotic Supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Inert Compound",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Sheppard Pratt Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 66,
      "start_date": "2012-11",
      "completion_date": "2016-12",
      "has_results": true,
      "last_update_posted_date": "2019-01-07",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01731171"
    },
    {
      "nct_id": "NCT00492583",
      "title": "Study to Investigate the Potential of Probiotics in Yogurt",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Bifidobacterium lactis (BB-12)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Georgetown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "3 Years",
        "sex": "ALL",
        "summary": "1 Year to 3 Years"
      },
      "enrollment_count": 182,
      "start_date": "2007-07",
      "completion_date": "2008-08",
      "has_results": true,
      "last_update_posted_date": "2011-08-17",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00492583"
    },
    {
      "nct_id": "NCT04414722",
      "title": "Mechanisms of Probiotics and Antibiotic-Associated Diarrhea",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Antibiotic-associated Diarrhea"
      ],
      "interventions": [
        {
          "name": "Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet",
          "type": "DRUG"
        },
        {
          "name": "BB-12",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Control Yogurt",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "Georgetown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 118,
      "start_date": "2021-01-01",
      "completion_date": "2023-05-01",
      "has_results": true,
      "last_update_posted_date": "2025-02-25",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04414722"
    },
    {
      "nct_id": "NCT03383874",
      "title": "A Probiotic Intervention to Prevent Relapse Following Hospitalization for Mania",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Mania (Neurotic)"
      ],
      "interventions": [
        {
          "name": "Probio-Tec BG-VCap-6.5",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "OTHER"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 67,
      "start_date": "2018-09-06",
      "completion_date": "2024-09-23",
      "has_results": true,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03383874"
    },
    {
      "nct_id": "NCT01399996",
      "title": "Influence of a Delivery System on the Efficacy of a Probiotic Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Delayed Transit Time",
        "Irregular Bowel Function"
      ],
      "interventions": [
        {
          "name": "Yogurt smoothie without probiotic",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Yogurt smoothie with probiotic added post fermentation",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Yogurt smoothie with probiotic added pre-fermentation",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "A capsule containing the probiotic",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Penn State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 36,
      "start_date": "2012-04",
      "completion_date": "2014-08",
      "has_results": false,
      "last_update_posted_date": "2023-08-21",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "University Park, Pennsylvania",
      "locations": [
        {
          "city": "University Park",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01399996"
    },
    {
      "nct_id": "NCT03755765",
      "title": "Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Antibiotic-associated Diarrhea"
      ],
      "interventions": [
        {
          "name": "Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet",
          "type": "DRUG"
        },
        {
          "name": "BB-12",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "Georgetown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 66,
      "start_date": "2019-07-23",
      "completion_date": "2020-01-08",
      "has_results": true,
      "last_update_posted_date": "2023-02-17",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03755765"
    },
    {
      "nct_id": "NCT01657643",
      "title": "Effect of Probiotics on Health-related Quality of Life in College Students With Upper Respiratory Infections",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Upper Respiratory Infection"
      ],
      "interventions": [
        {
          "name": "Probiotics",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Medicine and Dentistry of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "18 Years to 25 Years"
      },
      "enrollment_count": 231,
      "start_date": "2011-01",
      "completion_date": "2011-05",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Framingham, Massachusetts",
      "locations": [
        {
          "city": "Framingham",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01657643"
    },
    {
      "nct_id": "NCT01652287",
      "title": "Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Children"
      ],
      "interventions": [
        {
          "name": "BB-12 supplemented strawberry yogurt",
          "type": "DRUG"
        },
        {
          "name": "Strawberry flavored yogurt",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Georgetown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "5 Years",
        "sex": "ALL",
        "summary": "1 Year to 5 Years"
      },
      "enrollment_count": 62,
      "start_date": "2013-02",
      "completion_date": "2014-07",
      "has_results": true,
      "last_update_posted_date": "2024-03-22",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01652287"
    },
    {
      "nct_id": "NCT01757054",
      "title": "Fecal Recovery of the Probiotic Bacteria Lactobacillus Rhamnosus GG (LGG) and Bifidobacterium Animalis Subspecies Lactis BB-12 (BB-12) in Healthy Humans Following Daily Consumption of a Probiotic Supplement",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Fecal Analysis"
      ],
      "interventions": [
        {
          "name": "ProNutrients Probiotic",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 27,
      "start_date": "2013-02",
      "completion_date": "2013-10",
      "has_results": false,
      "last_update_posted_date": "2013-10-30",
      "last_synced_at": "2026-09-28T11:22:18.942Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01757054"
    }
  ]
}