{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Progesterone+supplementation",
    "query": {
      "intervention": "Progesterone supplementation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 16,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Progesterone+supplementation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-04T15:16:02.301Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03440359",
      "title": "Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Polycystic Ovary Syndrome"
      ],
      "interventions": [
        {
          "name": "Progesterone Vaginal Gel 8%",
          "type": "DRUG"
        },
        {
          "name": "Letrozole Oral Tablet",
          "type": "DRUG"
        },
        {
          "name": "pelvic ultrasound",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Ovidrel 250 MCG Per 0.5 ML Prefilled Syringe",
          "type": "DRUG"
        },
        {
          "name": "Intrauterine insemination or timed intercourse",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIAGNOSTIC_TEST",
        "OTHER"
      ],
      "sponsor": "Eastern Virginia Medical School",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "20 Years to 40 Years · Female only"
      },
      "enrollment_count": 52,
      "start_date": "2012-07-06",
      "completion_date": "2017-12-30",
      "has_results": false,
      "last_update_posted_date": "2018-02-26",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 1,
      "location_summary": "Norfolk, Virginia",
      "locations": [
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03440359"
    },
    {
      "nct_id": "NCT07448597",
      "title": "Progesterone Preeclampsia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Preeclampsia",
        "Hypertensive Disorder of Pregnancy"
      ],
      "interventions": [
        {
          "name": "Progesterone supplementation",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 642,
      "start_date": "2026-08-13",
      "completion_date": "2028-08-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-17",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07448597"
    },
    {
      "nct_id": "NCT00135902",
      "title": "Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Preterm Birth"
      ],
      "interventions": [
        {
          "name": "17 alpha-Hydroxyprogesterone Caproate and Omega-3 supplement",
          "type": "DRUG"
        },
        {
          "name": "17 alpha-hydroxy progesterone caproate and Placebo supplement",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The George Washington University Biostatistics Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 800,
      "start_date": "2005-02",
      "completion_date": "2008-03",
      "has_results": false,
      "last_update_posted_date": "2019-07-12",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 12,
      "location_summary": "Birmingham, Alabama • Chicago, Illinois • Detroit, Michigan + 9 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00135902"
    },
    {
      "nct_id": "NCT00743574",
      "title": "Health Benefits of Vitamin D and Calcium in Women With PCOS (Polycystic Ovarian Syndrome)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Polycystic Ovarian Syndrome",
        "Vitamin D Deficiency"
      ],
      "interventions": [
        {
          "name": "Vitamin D2 (Ergocalciferol)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Medroxyprogesterone (Provera)",
          "type": "DRUG"
        },
        {
          "name": "Vitamin D3 (Cholecalciferol)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Elemental Calcium",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 36,
      "start_date": "2008-08",
      "completion_date": "2013-02",
      "has_results": true,
      "last_update_posted_date": "2021-08-13",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00743574"
    },
    {
      "nct_id": "NCT03720847",
      "title": "Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Suicidal Ideation"
      ],
      "interventions": [
        {
          "name": "Estradiol Transdermal Patch 0.1 mg/24 hrs",
          "type": "DRUG"
        },
        {
          "name": "Oral Micronized Progesterone",
          "type": "DRUG"
        },
        {
          "name": "Inactive Clear Patch",
          "type": "DRUG"
        },
        {
          "name": "Placebo capsule",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2016-12-31",
      "completion_date": "2017-11",
      "has_results": true,
      "last_update_posted_date": "2019-02-04",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03720847"
    },
    {
      "nct_id": "NCT04549116",
      "title": "Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Infertility"
      ],
      "interventions": [
        {
          "name": "Progesterone-IBSA Injectable Solution",
          "type": "DRUG"
        },
        {
          "name": "Progesterone Vaginal Gel with Applicator",
          "type": "DRUG"
        },
        {
          "name": "Placebo Vaginal gel with applicator",
          "type": "DRUG"
        },
        {
          "name": "Placebo injectable solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "IBSA Institut Biochimique SA",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "42 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 42 Years · Female only"
      },
      "enrollment_count": 688,
      "start_date": "2022-10-12",
      "completion_date": "2026-08-25",
      "has_results": false,
      "last_update_posted_date": "2026-08-27",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 24,
      "location_summary": "Tempe, Arizona • Encino, California • Los Angeles, California + 20 more",
      "locations": [
        {
          "city": "Tempe",
          "state": "Arizona"
        },
        {
          "city": "Encino",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04549116"
    },
    {
      "nct_id": "NCT05704036",
      "title": "Estrogen Supplementation and Bone Health in Women With CF",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Cystic Fibrosis",
        "Hypoestrogenism"
      ],
      "interventions": [
        {
          "name": "Transdermal estrogen",
          "type": "DRUG"
        },
        {
          "name": "Progesterone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Years",
        "maximum_age": "100 Years",
        "sex": "FEMALE",
        "summary": "0 Years to 100 Years · Female only"
      },
      "enrollment_count": 75,
      "start_date": "2023-05-02",
      "completion_date": "2027-01",
      "has_results": false,
      "last_update_posted_date": "2025-11-14",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05704036"
    },
    {
      "nct_id": "NCT00615251",
      "title": "A Clinical Trial to Evaluate the Efficacy and Safety of DR-2011 for In Vitro Fertilization",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Infertility"
      ],
      "interventions": [
        {
          "name": "DR-2011",
          "type": "DRUG"
        },
        {
          "name": "Crinone 8%",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duramed Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "42 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 42 Years · Female only"
      },
      "enrollment_count": 1297,
      "start_date": "2008-02",
      "completion_date": "2009-08",
      "has_results": false,
      "last_update_posted_date": "2013-09-13",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 29,
      "location_summary": "Tarzana, California • West Los Angeles, California • Westlake, California + 26 more",
      "locations": [
        {
          "city": "Tarzana",
          "state": "California"
        },
        {
          "city": "West Los Angeles",
          "state": "California"
        },
        {
          "city": "Westlake",
          "state": "California"
        },
        {
          "city": "Clearwater",
          "state": "Florida"
        },
        {
          "city": "Alpharetta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00615251"
    },
    {
      "nct_id": "NCT06834594",
      "title": "Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Turner Syndrome",
        "Primary Ovarian Insufficiency (Poi)"
      ],
      "interventions": [
        {
          "name": "Micronized progesterone 200 MG",
          "type": "DRUG"
        },
        {
          "name": "Micronized Progesterone 100 MG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Mercy Hospital Kansas City",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "20 Years",
        "sex": "FEMALE",
        "summary": "12 Years to 20 Years · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2025-07-31",
      "completion_date": "2028-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-25",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 1,
      "location_summary": "Kansas City, Missouri",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06834594"
    },
    {
      "nct_id": "NCT03530254",
      "title": "Clinical Study of PGT-A Versus PGT-A+ERA",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infertility of Uterine Origin"
      ],
      "interventions": [
        {
          "name": "PGT-A",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "ERA Test",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Igenomix",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 368,
      "start_date": "2018-05-28",
      "completion_date": "2022-02-22",
      "has_results": false,
      "last_update_posted_date": "2022-05-04",
      "last_synced_at": "2026-09-04T15:16:02.301Z",
      "location_count": 2,
      "location_summary": "Newport Beach, California • Reading, Massachusetts",
      "locations": [
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Reading",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03530254"
    }
  ]
}