{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Prolonged+Exposure+Therapy+for+Posttraumatic+Stress+Disorder",
    "query": {
      "intervention": "Prolonged Exposure Therapy for Posttraumatic Stress Disorder"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 77,
    "total_pages": 8,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Prolonged+Exposure+Therapy+for+Posttraumatic+Stress+Disorder&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-28T17:23:39.391Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01338506",
      "title": "Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Posttraumatic Stress Disorders",
        "Combat Disorders",
        "Alcohol Dependence",
        "Drug Dependence"
      ],
      "interventions": [
        {
          "name": "Concurrent Treatment with Prolonged Exposure (COPE)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 81,
      "start_date": "2011-04",
      "completion_date": "2016-03",
      "has_results": true,
      "last_update_posted_date": "2020-02-11",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01338506"
    },
    {
      "nct_id": "NCT00239772",
      "title": "Cognitive Processing Therapy Versus Prolonged Exposure for Treating Women With Post-Traumatic Stress Disorder Brought on by Sexual Assault",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post-Traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Cognitive Processing Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Prolonged Exposure Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Missouri, St. Louis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 120,
      "start_date": "1994-05",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2014-06-05",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00239772"
    },
    {
      "nct_id": "NCT04471207",
      "title": "Clinical Trial Intelligent Biometrics for PTSD - Clinical Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "PTSD"
      ],
      "interventions": [
        {
          "name": "Therapist Guided Prolonged Exposure with BioWare Device",
          "type": "DEVICE"
        },
        {
          "name": "Record Only Prolonged Exposure with BioWare Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 40,
      "start_date": "2020-06-08",
      "completion_date": "2022-03-08",
      "has_results": true,
      "last_update_posted_date": "2023-10-31",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04471207"
    },
    {
      "nct_id": "NCT06288711",
      "title": "Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid Use Disorder",
        "Posttraumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Prolonged exposure therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Financial incentives",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment as usual",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 135,
      "start_date": "2024-06-03",
      "completion_date": "2027-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-05-18",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "Burlington, Vermont",
      "locations": [
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06288711"
    },
    {
      "nct_id": "NCT06670079",
      "title": "Prolonged Exposure Therapy to Treat Posttraumatic Stress Disorder in Pregnant Patients",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Posttraumatic Stress Disorder",
        "Pregnancy"
      ],
      "interventions": [
        {
          "name": "Prolonged exposure therapy + incentives for therapy session attendance",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2026-02-05",
      "completion_date": "2027-07-22",
      "has_results": false,
      "last_update_posted_date": "2026-05-13",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "Burlington, Vermont",
      "locations": [
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06670079"
    },
    {
      "nct_id": "NCT03343028",
      "title": "Biomarker Establishment for Superior Treatment of PTSD",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "PTSD"
      ],
      "interventions": [
        {
          "name": "Psychotherapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 292,
      "start_date": "2016-09",
      "completion_date": "2019-09-30",
      "has_results": false,
      "last_update_posted_date": "2020-02-12",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 2,
      "location_summary": "Palo Alto, California • Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03343028"
    },
    {
      "nct_id": "NCT06266364",
      "title": "Targeted Plasticity Therapy for PTSD",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "PTSD, Post Traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Active VNS stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Sham VNS stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas at Dallas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "22 Years to 79 Years"
      },
      "enrollment_count": 20,
      "start_date": "2024-12-30",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-09-16",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 3,
      "location_summary": "Austin, Texas • Dallas, Texas • Richardson, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        },
        {
          "city": "Richardson",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06266364"
    },
    {
      "nct_id": "NCT01459705",
      "title": "Comparing Virtual Reality Exposure Therapy to Prolonged Exposure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stress Disorders",
        "Post-Traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Prolonged Exposure Therapy (PE)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Virtual Reality Exposure Therapy (VRET)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Waitlist",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "National Center for Telehealth and Technology",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 162,
      "start_date": "2011-10",
      "completion_date": "2014-05",
      "has_results": true,
      "last_update_posted_date": "2015-12-14",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "Fort Bragg, North Carolina",
      "locations": [
        {
          "city": "Fort Bragg",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01459705"
    },
    {
      "nct_id": "NCT01542229",
      "title": "PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post Traumatic Stress Disorder",
        "Schizophrenia",
        "Schizoaffective Disorder",
        "Bipolar Disorder",
        "Major Depression"
      ],
      "interventions": [
        {
          "name": "Prolonged Exposure for PTSD (PE) + Treatment as Usual (TAU)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment As Usual (TAU)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 134,
      "start_date": "2012-05-03",
      "completion_date": "2016-12-31",
      "has_results": true,
      "last_update_posted_date": "2019-07-15",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01542229"
    },
    {
      "nct_id": "NCT00121888",
      "title": "Trial of Paroxetine-CR for the Treatment of Patients With Post Traumatic Stress Disorder Remaining Symptomatic After Initial Exposure Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Stress Disorders, Post-Traumatic"
      ],
      "interventions": [
        {
          "name": "Prolonged Exposure Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Paroxetine-CR",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "72 Years",
        "sex": "ALL",
        "summary": "18 Years to 72 Years"
      },
      "enrollment_count": 60,
      "start_date": "2002-12",
      "completion_date": "2007-06",
      "has_results": false,
      "last_update_posted_date": "2014-06-06",
      "last_synced_at": "2026-09-28T17:23:39.391Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00121888"
    }
  ]
}